Headache Clinical Trials

19 studies are recruiting for headache in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Aurora, Colorado 3 Cincinnati, Ohio 3

Studies now recruiting

  1. Immediate Neuromuscular Responses of the Obliquus Capitis Inferior Following Upper Cervical Manual Therapy

    This study used a prospective, randomized, repeated-measures experimental design to investigate the immediate effects of two upper cervical manual therapy interventions on craniovertebral angle (CVA), clinician-perceived atlas position, and musculoskeletal ultrasound-derived obliquus capitis inferi…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Florida Gulf Coast University Marieb Hall 101, Fort Myers, Florida
    Run by
    Florida Gulf Coast University

    See if you can join NCT07725198 on ClinicalTrials.gov

  2. Responding With Evidence and Access for Childhood Headaches

    This comparative effectiveness study will clarify current first-line preventive treatment approaches for use by neurologists, psychologists, and primary care providers in the context of real world care, and will demonstrate the feasibility of Cognitive Behavioral Therapy (CBT) via telehealth for yo…

    Stage
    Not phased
    Ages
    10 to 17
    Site
    University of Alabama at Birmingham Children's of Alabama, Birmingham, Alabama
    Locations
    15 in total
    Run by
    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05889624 on ClinicalTrials.gov

  3. Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches

    This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in frequency and/or intensity than individuals who undergo the current st…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Northwell Health - North Shore University Hospital, Manhasset, New York
    Run by
    Northwell Health

    See if you can join NCT04685772 on ClinicalTrials.gov

  4. Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache

    The study titled \"Transnasal sphenopalatine ganglion block for treatment of acute subarachnoid hemorrhage associated headache\" is a randomized controlled pilot study aimed at evaluating the efficacy of a transnasal sphenopalatine ganglion (SPG) block in addition to standard pain medicatio…

    Stage
    Phase 2
    Ages
    18 to 100
    Site
    UC Davis Medical Center, Sacramento, California
    Run by
    University of California, Davis

    See if you can join NCT06621329 on ClinicalTrials.gov

  5. Headache Ear Auditory Dizziness Sinus (HEADS) Registry

    The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms. Through an online portal, participants are asked questions about their symptoms, how they have affected t…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Association of Migraine Disorders, North Kingstown, Rhode Island
    Run by
    Association of Migraine Disorders

    See if you can join NCT07754266 on ClinicalTrials.gov

  6. Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches

    The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1. show that intravenous lidocaine infusion causes a clinically significa…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ascension Via Christi St. Francis, Wichita, Kansas
    Run by
    University of Kansas Medical Center

    See if you can join NCT06582810 on ClinicalTrials.gov

  7. BLOCK-SAH - PPF-Block for Post-SAH Headache

    BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine + 4mg dexamethasone (active, PPF-block) compared to saline (placebo) for …

    Stage
    Phase 2
    Ages
    18 to 85
    Site
    University of Florida, Gainesville, Florida
    Locations
    13 in total
    Run by
    University of Florida

    See if you can join NCT06008795 on ClinicalTrials.gov

  8. Placebo Impacts Sleep and Pain Modulation in Chronic Pain

    The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with temporomandibular disorders. This study will enroll a cohort of participants with …

    Stage
    Not phased
    Ages
    18 to 88
    Site
    University of Maryland Baltimore School of Nursing, Baltimore, Maryland
    Run by
    University of Maryland, Baltimore

    See if you can join NCT06225817 on ClinicalTrials.gov

  9. Mind Body Balance for Pediatric Migraine

    This study uses a factorial research design to evaluate a nurse delivered mind body intervention using different doses of 3 treatment components to determine the optimized treatment for headache day reduction.

    Stage
    Not phased
    Ages
    10 to 17
    Site
    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
    Locations
    2 in total
    Run by
    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT04715685 on ClinicalTrials.gov

  10. Determining the Utility of a Behavioral Intervention in Chronic Migraine

    This proposal will involve a pilot study to evaluate the feasibility, acceptability, and outcomes of a lifestyle behavior protocol in managing chronic migraine. Additionally, the proposal will investigate biomolecules that are uniquely involved in chronic migraine patients who respond to the protoc…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Phoenix, Arizona
    Run by
    Mayo Clinic

    See if you can join NCT05415020 on ClinicalTrials.gov

  11. Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid Hemorrhage

    In patients with bleeding from a brain aneurysm, severe headache is the most common complaint. However, the pain is difficult to treat. The use of standard pain medications is common, but pain control remains poor. Additionally, pain medicines have multiple side effects including sedation, interfer…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Miami Valley Hospital, Dayton, Ohio
    Run by
    Wright State University

    See if you can join NCT07116408 on ClinicalTrials.gov

  12. External Trigeminal Nerve Stimulation for Migraine Treatment in Pregnancy

    This online registry aims to understand the potential benefits and safety of external trigeminal nerve stimulation for the treatment of migraine in pregnant women. Women do not need to use external trigeminal nerve stimulation or any other form of migraine treatment to participate in the registry. …

    Stage
    Not phased
    Ages
    18 to 44
    Site
    https://public.smart-trial.co/#/public/649d77f0e8f8d0fb993d0c61/6626f6a04f0a3c7dd0860e14/662726d84f0a3c7dd08aeaa0/signup?lang=en-us&enforceLanguage=true, Darien, Connecticut
    Run by
    Cefaly Technology

    See if you can join NCT06788977 on ClinicalTrials.gov

  13. Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain

    The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and/or active military personnel by alleviating Gulf War Illness related headaches and body pain (GWI-HAP). This study aims to deve…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Jennifer Moreno Department of Veterans Affairs Medical Center, San Diego, California
    Run by
    Veterans Medical Research Foundation

    See if you can join NCT07325513 on ClinicalTrials.gov

  14. Personalized Brain Stimulation to Treat Chronic Concussive Symptoms

    The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that oc…

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    UCLA, Westwood, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT06073886 on ClinicalTrials.gov

  15. Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage

    The goal of this clinical trial is to learn if an infusion of lidocaine, with or without steroids, into the middle meningeal artery (MMA) helps relieve severe headaches in patients with spontaneous subarachnoid hemorrhage (SAH). It will also study the safety of this treatment.

    Stage
    Phase 2
    Ages
    18 to 100
    Site
    University of Texas Medical Branch, Galveston, Galveston, Texas
    Run by
    The University of Texas Medical Branch, Galveston

    See if you can join NCT07294118 on ClinicalTrials.gov

  16. Concussion Recovery and Support Program

    Pilot randomized controlled trial (RCT) comparing a novel intervention Concussion Recovery and Support Program (CRISP) for adolescents and young adults (AYA) 18-29 yo with concussion/ mild TBI.

    Stage
    Not phased
    Ages
    18 to 29
    Site
    Seattle Children's Research Institute, Seattle, Washington
    Locations
    2 in total
    Run by
    Seattle Children's Hospital

    See if you can join NCT07097792 on ClinicalTrials.gov

  17. Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

    This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effec…

    Stage
    Phase 1
    Ages
    18 to 55
    Site
    SUNY Upstate Medical University, Syracuse, New York
    Run by
    State University of New York - Upstate Medical University

    See if you can join NCT06112093 on ClinicalTrials.gov

  18. Puberty, Testosterone, and Brain Development

    Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache. Researchers think this because studies published on effects of giving testosterone to cisgender females (fem…

    Stage
    Not phased
    Ages
    12 to 20
    Site
    Children's Hospital Colorado, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT06670053 on ClinicalTrials.gov

  19. Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

    This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide …

    Stage
    Not phased
    Ages
    18 to 65
    Site
    VA San Diego Healthcare System, San Diego, California
    Run by
    Veterans Medical Research Foundation

    See if you can join NCT05176392 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.