Glioma Clinical Trials

50 studies are recruiting for glioma in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial

   This clinical trial tests how well a digital treatment platform using a mobile application works for the delivery of home-based sequential therapy in patients with glioma. Access to specialized neuro-oncology care in the United States for patients with glioma is critically deficient. Care at center…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Florida, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Mayo Clinic

   See if you can join NCT07074756 on ClinicalTrials.gov

2. Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

   This is a pilot clinical trial determining the effect of a Methionine-reduced diet on serum levels in subjects with solid tumors. These are subjects who will receive systemic standard of care cancer therapy.

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California

   Run by

   University of California, Irvine

   See if you can join NCT07628634 on ClinicalTrials.gov

3. A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

   This is an open-label, multicenter dose-escalation study to be followed by a dose expansion to define the optimal dose of GLIX1 as monotherapy by reviewing safety and tolerability, disease characteristics and pharmacokinetic profiles and preliminary clinical activity in participants with a high gra…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Locations

   3 in total

   Run by

   Tetragon Biosciences Ltd

   See if you can join NCT07464925 on ClinicalTrials.gov

4. Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

   This study will test the safety and effectiveness of a combination of pembrolizumab, olaparib, and temozolomide to see how well these drugs work when given together in people with a glioma that either did not respond to previous treatment or came back after treatment.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Hartford Healthcare Alliance (Data Collection Only), Hartford, Connecticut

   Locations

   10 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT05188508 on ClinicalTrials.gov

5. Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

   High-grade gliomas (HGGs) are among the most aggressive and treatment-resistant brain tumors. Immunotherapy with checkpoint inhibitors like nivolumab has shown promise, but its efficacy remains variable and poorly understood in this patient population. This clinical trial investigates a novel imagi…

   Stage

   EARLY_Phase 1

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Eben Rosenthal

   See if you can join NCT07210632 on ClinicalTrials.gov

6. Hyperpolarized Imaging in Diagnosing Participants With Glioma

   This pilot trial studies the side effects of hyperpolarized carbon C 13 pyruvate magnetic resonance imaging (MRI) in diagnosing participants with glioma. Diagnostic procedures, such as hyperpolarized carbon C 13 pyruvate MRI, may help find and diagnose glioma.

   Stage

   Phase 1

   Ages

   19 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   Susan Chang

   See if you can join NCT03739411 on ClinicalTrials.gov

7. Sitagliptin in Recurrent/Progressive Grade 4 Glioma

   Sitagliptin, when combined with standard-of-care drug bevacizumab, is being tested to 1) find out if it is effective at treating gliomas that have returned or progressed after treatment, and 2) find out what the highest dose of sitagliptin is appropriate to give when combined with bevacizumab.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Iowa Health Care, Iowa City, Iowa

   Run by

   Kailin Yang, MD, PhD

   See if you can join NCT07541781 on ClinicalTrials.gov

8. Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

   In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired throug…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Moores Cancer Center, San Diego, California

   Run by

   Jona Hattangadi-Gluth

   See if you can join NCT05576103 on ClinicalTrials.gov

9. A Study of 177Lu-PSMA-617 in People With Gliomas

   The researchers are doing this study to find out whether the radiopharmaceutical therapy (RPT) 177Lu-PSMA-617 is a safe treatment for people with IDH wild type glioma.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

   Locations

   7 in total

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT07223034 on ClinicalTrials.gov

10. Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

    This single center, single arm, open-label, phase I study will assess the safety of laparoscopically harvested autologous omentum, implanted into the resection cavity of recurrent glioblastoma multiforme (GBM) patients.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lenox Hill Brain Tumor Center, New York, New York

    Run by

    Northwell Health

    See if you can join NCT05979064 on ClinicalTrials.gov

11. PrOton Pulsed reduCed dOse Rate Radiotherapy for Recurrent CNS maligNancies Trial

    The purpose of this research study is to see if a specific type of radiation therapy, called "proton pulsed reduced dose rate" or "PRDR radiotherapy" has any benefits at dose levels and number of fractions thought to be acceptable in earlier research studies. The researchers want to find out what e…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Miami Cancer Institute at Baptist Health, Inc., Miami, Florida

    Locations

    2 in total

    Run by

    Baptist Health South Florida

    See if you can join NCT06397560 on ClinicalTrials.gov

12. LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

    The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maryland Proton Treatment Center, Baltimore, Maryland

    Locations

    5 in total

    Run by

    University of Maryland, Baltimore

    See if you can join NCT04699773 on ClinicalTrials.gov

13. Non-invasive Glioma Characterization Through Molecular Imaging

    MRI-based sequences can provide non-invasive quantification of intratumoral 2-hydroxyglutarate (2HG) distribution and tumor cellularity in human gliomas and help guide the development of novel glioma therapies.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Miami, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT03684109 on ClinicalTrials.gov

14. A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors

    This is a two-part Phase 1, open label, multi-center, single arm, non-randomized, multiple dose, safety, pharmacokinetic (PK) and preliminary efficacy study of single agent NST-628 in adult patients with MAPK pathway mutated/dependent advanced solid tumors who have exhausted standard treatment opti…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California

    Locations

    23 in total

    Run by

    Nested Therapeutics, Inc

    See if you can join NCT06326411 on ClinicalTrials.gov

15. A Study Utilizing Escitalopram in Glioma Patients

    Glioma is a cancer of glial cells, a class of tissue supporting neuronal function in the brain. As many as 85% of glioma patients experience cognitive impairment. This is not only from direct tumor involvement, but also from therapy such as cranial radiation and chemotherapy, which degrades neurona…

    Stage

    Phase 2

    Ages

    19 and older

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT03728673 on ClinicalTrials.gov

16. ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

    This is a randomized, double-blind, placebo-controlled, parallel-group, international, Phase 3 study in patients with newly diagnosed H3 K27M-mutant diffuse glioma to assess whether treatment with dordaviprone (ONC201) following frontline radiotherapy will extend overall survival and progression-fr…

    Stage

    Phase 3

    Ages

    Any age

    Site

    FLENI Neurologia, Buenos Aires,

    Locations

    162 in total

    Run by

    Jazz Pharmaceuticals

    See if you can join NCT05580562 on ClinicalTrials.gov

17. Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

    Primary brain tumors are typically treated by surgery, radiation therapy and chemotherapy, either individually or in combination. Present therapies are inadequate, as evidenced by the low 5-year survival rate for brain cancer patients, with median survival at approximately 12 months. Glioma is the …

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Lenox Hill Brain Tumor Center, New York, New York

    Run by

    Northwell Health

    See if you can join NCT02800486 on ClinicalTrials.gov

18. Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

    This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4+ and CD8+ T cells lentivirally transduced to express a B7H3-specific chimeric antigen receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cav…

    Stage

    Phase 1

    Ages

    1 to 26

    Site

    Seattle Children's Hospital, Seattle, Washington

    Run by

    Seattle Children's Hospital

    See if you can join NCT04185038 on ClinicalTrials.gov

19. All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

    This is a Phase II study of the combination of All-Trans Retinonic Acid (ATRA) and PD-1 inhibition (Retifanlimab) in patient with recurrent IDH-mutant glioma. The Sponsor-Investigator hypothesizes that the proposed regimen will be safe and stimulate a robust anti-tumor immune response.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Stephen Bagley, MD, MSCE

    See if you can join NCT05345002 on ClinicalTrials.gov

20. Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

    This phase I trial studies how well zirconium (Zr)-89 crefmirlimab berdoxam and immuno-positron emission tomography (PET) identifies areas of immune cell activity in patients with brain tumors that can be removed by surgery (resectable). One important predictor of the immune response is the presenc…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California

    Run by

    Jonsson Comprehensive Cancer Center

    See if you can join NCT06650163 on ClinicalTrials.gov

21. Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

    High grade gliomas (HGGs) are rapidly progressive brain tumors resulting in death for most patients between 6 months and 2 years after diagnosis. It is important for patients with HGG to discuss and document their wishes at the end of life. However, many of these patients experience early changes i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rochester, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT04543201 on ClinicalTrials.gov

22. Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

    The primary goal of this Phase I study is to determine the maximum tolerated dose of oncolytic adenovirus mediated double suicide-gene therapy in combination with fractionated stereotactic radiosurgery in patients with recurrent high-grade astrocytoma undergoing resection.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Henry Ford Health System, Detroit, Michigan

    Run by

    Henry Ford Health System

    See if you can join NCT05686798 on ClinicalTrials.gov

23. 18F-Fluciclovine PET-MRI in High-grade Glioma

    The purpose of this study is to see if 18F-fluciclovine (Axumin®) PET imaging is useful and safe in the management of children with High Grade Gliomas. Investigators seek to determine if this imaging will help doctors tell the difference between tumor growth (progression) and other tumor changes th…

    Stage

    EARLY_Phase 1

    Ages

    1 to 21

    Site

    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT05553041 on ClinicalTrials.gov

24. Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

    The purpose of this study is to examine the safety and feasibility of performing hyperpolarized metabolic MRI in the diagnosis of brain tumor. This study will also assess the accuracy of hyperpolarized metabolic MRI to diagnose intermediate to patients with infiltrating gliomas and examine the adde…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    Rosy Njonkou Tchoquessi, Baltimore, Maryland

    Run by

    University of Maryland, Baltimore

    See if you can join NCT04772456 on ClinicalTrials.gov

25. Registering Genomics and Imaging of Tumors (ReGIT)

    This study is investigating how brain tumors might mutate over time, and whether new brain imaging tools like MRI and PET can predict these mutations.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Indiana University School of Medicine, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT05386043 on ClinicalTrials.gov