Gestational Diabetes Clinical Trials

22 studies are recruiting for gestational diabetes in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

   The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.

   Stage

   EARLY_Phase 1

   Ages

   18 to 50

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Anna Stanhewicz, PhD

   See if you can join NCT05946785 on ClinicalTrials.gov

2. Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM

   Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy. While subsequent development of type II diabetes elevates this risk, prior GDM is an independent risk factor for CVD m…

   Stage

   EARLY_Phase 1

   Ages

   18 to 50

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Anna Stanhewicz, PhD

   See if you can join NCT06547619 on ClinicalTrials.gov

3. Pregnancy and Postpartum CGM in GDM

   Gestational diabetes (GDM) is one of the most common complications of pregnancy, and up to one third of women with GDM will have abnormal blood sugars after their pregnancy. To screen for abnormal blood sugars, standard of care is a 4-12 week postpartum oral glucose tolerance test (OGTT). However o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07174245 on ClinicalTrials.gov

4. Delivering HOPE (Helping Women Optimize Prenatal Equity)

   The overarching research question is: "Does the provision of healthy food (Delivering HOPE) during pregnancy reduce the proportion of women who experience excessive gestational weight gain compared with enhanced standard of care (ESoC)?" To answer this question, the investigators will conduct a lar…

   Stage

   Not phased

   Ages

   16 to 44

   Site

   1st Choice Healthcare, Corning, Arkansas

   Locations

   8 in total

   Run by

   University of Arkansas

   See if you can join NCT06814509 on ClinicalTrials.gov

5. Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes

   This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   5 in total

   Run by

   Indiana University

   See if you can join NCT05124808 on ClinicalTrials.gov

6. Growth Hormone Resistance of Beta-cells A

   The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim…

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Missouri School of Medicine, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT06571487 on ClinicalTrials.gov

7. Cardiometabolic Disease and Substrate Metabolism

   This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.

   Stage

   Not phased

   Ages

   18 to 45

   Site

   University of Tennessee Graduate School of Medicine, Knoxville, Tennessee

   Run by

   University of Tennessee Graduate School of Medicine

   See if you can join NCT07565727 on ClinicalTrials.gov

8. Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

   This study is being done to study how exenatide, an FDA-approved drug that lowers blood sugar in non-pregnant patients with type II diabetes, works in pregnant women. To do this, the investigators will study the drug's pharmacokinetics (what the body does to the drug; specifically, how quickly your…

   Stage

   Phase 4

   Ages

   18 to 50

   Site

   Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania

   Run by

   Maisa N. Feghali, MD

   See if you can join NCT05482789 on ClinicalTrials.gov

9. Single vs Multi-Dose Insulin for Glycemic Control (SUGAR)

   The goal of this clinical trial is to see if diabetes in pregnancy can be treated with once daily dosing of insulin instead of once daily dosing plus insulin with meals. The main question this study aims to answer is: 1. Can a once daily dose of long-acting insulin control blood sugars as well as l…

   Stage

   Not phased

   Ages

   18 to 50

   Site

   Robert Wood Johnson Univeristy Hospital, New Brunswick, New Jersey

   Locations

   2 in total

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT07171684 on ClinicalTrials.gov

10. Early Investigation of Glucose Monitoring After Gestational Diabetes Pilot

    One third of women with gestational diabetes (GDM), diabetes diagnosed during pregnancy, have abnormal glucose levels within 3 years after pregnancy, but follow up is low. Continuous glucose monitors (CGM), a small sensor inserted under the skin, may be able to screen women with GDM for diabetes ri…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Ohio State University Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06184373 on ClinicalTrials.gov

11. A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE

    DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care) to improve the frequency of post-partum diabetes screening among indivi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT05909046 on ClinicalTrials.gov

12. Nutrition Optimization and Community Upliftment for Postpartum Recovery

    The goal of this clinical trial is to better understand how different strategies, timing, and enhancements to medically tailored food delivery will address structural inequities in the food environment, empower communities to sustain behavior change, and ultimately improve postpartum weight control…

    Stage

    Not phased

    Ages

    18 and older

    Site

    East Baltimore Medical Campus, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06445530 on ClinicalTrials.gov

13. Glucose Empowerment Through Monitoring and Social Support in Pregnancy

    The purpose of the research is to learn whether wearing a continuous glucose monitor that shows blood glucose levels in real time on a smart phone app and participating in a group chat with other research participants will help participants keep a healthy blood glucose level during pregnancy. High …

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Tufts Medical Center, Boston, Massachusetts

    Run by

    Tufts Medical Center

    See if you can join NCT07009704 on ClinicalTrials.gov

14. Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

    This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    University of Tennessee Medical Center, Knoxville, Tennessee

    Run by

    University of Tennessee Graduate School of Medicine

    See if you can join NCT06802861 on ClinicalTrials.gov

15. Immediate Postpartum Glucose Tolerance Testing

    The objective of this study is to compare the accuracy of a 2hr glucose tolerance test administered during the postpartum hospitalization with the standard of care glucose tolerance testing (administered at 6 weeks postpartum). The primary hypothesis is that the glucose tolerance test administered …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Long Beach Memorial Medical Center/Miller Children's and Women's Hospital, Long Beach, California

    Run by

    MemorialCare Health System

    See if you can join NCT04199676 on ClinicalTrials.gov

16. Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics

    The primary objective of the STRIVE study is to compare two implementation strategies for Diabetes Prevention Program delivery: an in-person health coach strategy (standard 24 in-person sessions at WIC clinics) vs. a multifaceted technology-assisted health coach implementation strategy (12 in-perso…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT06116149 on ClinicalTrials.gov

17. Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes

    The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease.

    Stage

    EARLY_Phase 1

    Ages

    18 to 45

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    Anna Stanhewicz, PhD

    See if you can join NCT05917587 on ClinicalTrials.gov

18. GDM: Insulin with or Without Metformin?

    This will be a randomized trial of patients with gestational diabetes who start hypoglycemic therapy with metformin but eventually require insulin. It will examine whether continuing metformin when adding insulin versus discontinuing metformin when insulin is added is beneficial. The investigators …

    Stage

    Phase 4

    Ages

    18 to 50

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06781775 on ClinicalTrials.gov

19. Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes (START 2)

    The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a Strict and permissive threshold. The Strict study arm target range will be 65-120 mg/dL, with tim…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    Thomas Jefferson University

    See if you can join NCT06419803 on ClinicalTrials.gov

20. Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes

    The aim of our study is to compare neonatal and maternal outcomes using different thresholds for the initiation and titration of pharmacotherapy for gestational diabetes (GDM). Our goal is to compare a strict and permissive threshold. The strict threshold is defined as two abnormal values or more o…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Locations

    2 in total

    Run by

    Thomas Jefferson University

    See if you can join NCT06419777 on ClinicalTrials.gov

21. DETERMINE: Detemir vs NPH

    The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT05124457 on ClinicalTrials.gov

22. iGlucose® Remote Patient Monitoring Device as an Adjunct to Routine Glucose Meter Devices for Glycemic Management and Control in Gestational Diabetes

    The purpose of this study is to investigate whether automation of glucose monitoring data to facilitate the total number of recommended and completed SMBG checks improve clinical outcomes for women living with gestational and type 2 diabetes during pregnancy? This is a RCT

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04206748 on ClinicalTrials.gov