Generalized Anxiety Disorder Clinical Trials

18 studies are recruiting for generalized anxiety disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder

   This is a global, phase 3, randomized, double-blind, parallel-group, 2-arm, placebo controlled, multicenter trial designed to compare the efficacy, safety and tolerability of a fixed dose of SEP-363856 (75 millligrams per day [mg/day]) to placebo over an 8-week double-blind treatment period in adul…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Anderson Clinical Research, Redlands, California

   Locations

   5 in total

   Run by

   Otsuka Pharmaceutical Development & Commercialization, Inc.

   See if you can join NCT07767903 on ClinicalTrials.gov

2. A Study to Asses Safety and Tolerability of ITI-1284 Given Alone or as an Additional Treatment in Participants With Generalized Anxiety Disorder (GAD)

   The purpose of this study is to assess how safe ITI-1284 is and how well it can be tolerated in long-term, when given alone or with other medicines, in participants with generalized anxiety disorder (GAD) who have not responded to treatment previously. GAD is a mental health condition defined by co…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   CalNeuro Research, Los Angeles, California

   Run by

   Intra-Cellular Therapies, Inc.

   See if you can join NCT07807865 on ClinicalTrials.gov

3. Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

   This is a multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of ITI-1284 compared with placebo as adjunctive therapy to GAD treatment in patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revisio…

   Stage

   Phase 2

   Ages

   Any age

   Site

   Behavioral Research Specialists LLC, Glendale, California

   Locations

   56 in total

   Run by

   Intra-Cellular Therapies, Inc.

   See if you can join NCT06480383 on ClinicalTrials.gov

4. Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder

   This is a multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of ITI-1284 as monotherapy treatment in patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for GAD in pati…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   51 in total

   Run by

   Intra-Cellular Therapies, Inc.

   See if you can join NCT06701903 on ClinicalTrials.gov

5. Anxiety Skills Study

   The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training compared to receiving 4 sessions of therapy, and (3) to evaluate how dura…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Psychology Building at Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07774481 on ClinicalTrials.gov

6. RE104 Safety and Efficacy Study in Generalized Anxiety Disorder

   The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces anxiety symptoms in participants with Generalized Anxiety Disorder (GAD) as compared to placebo.

   Stage

   Phase 2

   Ages

   18 to 74

   Site

   University of Alabama (UAB) Clinical Research Unit (CRU), Birmingham, Alabama

   Locations

   28 in total

   Run by

   Reunion Neuroscience Inc

   See if you can join NCT07489651 on ClinicalTrials.gov

7. A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety Disorder

   This is a global, phase 3, randomized, double-blind, parallel-group, 3-arm, placebo-controlled, multicenter study designed to compare the efficacy, safety, and tolerability of fixed doses of SEP-363856 (50 and 75 milligrams per day [mg/day]) to placebo in adults at least 18 years of age with genera…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Clinical Neuroscience Solutions, LLC, Jacksonville, Florida

   Locations

   3 in total

   Run by

   Otsuka Pharmaceutical Development & Commercialization, Inc.

   See if you can join NCT07759128 on ClinicalTrials.gov

8. Testing Delivery Modalities of Team-Based CBT for Pediatric Anxiety in Community Health Settings.

   The purpose of this study is to test how the delivery of Cognitive Behavioral Therapy (CBT) for pediatric anxiety and OCD via different methods might increase its availability and effectiveness. CBT involves teaching the patient skills to enable them to gradually come into contact with feared situa…

   Stage

   Not phased

   Ages

   5 to 18

   Site

   Bradley Hospital, East Providence, Rhode Island

   Run by

   Bradley Hospital

   See if you can join NCT06934525 on ClinicalTrials.gov

9. Mindful Self-Compassion for Anxiety Disorders and Depression

   The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or …

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Georgetown University Medical Center, Washington D.C., District of Columbia

   Run by

   Georgetown University

   See if you can join NCT05671419 on ClinicalTrials.gov

10. Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

    Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Acacia Clinics, Sunnyvale, California

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06376734 on ClinicalTrials.gov

11. CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy

    Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid c…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Boston University, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Jasper A. Smits

    See if you can join NCT05467683 on ClinicalTrials.gov

12. Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4

    This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own b…

    Stage

    Not phased

    Ages

    18 to 24

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06563310 on ClinicalTrials.gov

13. Triage Survey for Psychiatry Research Eligibility

    TRIAGE-Psych is a survey study designed to assess potential participants' eligibility to screen for industry-sponsored psychiatry clinical trials.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Adams Clinical, Boston, Boston, Massachusetts

    Locations

    6 in total

    Run by

    Adams Clinical

    See if you can join NCT05800925 on ClinicalTrials.gov

14. Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

    The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depress…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Georgetown University Medical Center, Washington D.C., District of Columbia

    Run by

    Georgetown University

    See if you can join NCT07028216 on ClinicalTrials.gov

15. Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

    There are few treatment options available for patients once they have failed standard psychopharmacological therapy for generalized anxiety disorder. Existing brain stimulation methods such as rTMS fail to target deep brain structures associated with anxiety disorders; structures such as the amygda…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    3 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT04557891 on ClinicalTrials.gov

16. Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity

    This project is designed to determine if a computer-delivered cognitive-behavioral treatment can improve the otherwise poor alcohol use disorder treatment outcomes for individuals with a co-occurring anxiety disorder. In the past, the investigators showed that this treatment does improve outcomes f…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Lodging Plus Program, Fairview Hospital, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05117255 on ClinicalTrials.gov

17. Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

    Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT05427708 on ClinicalTrials.gov

18. Brief Smartphone Treatment Study

    Little is known about whether and how brief mindfulness therapies yield clinically beneficial effects. This gap exists despite the rapid growth of smartphone mindfulness applications and presence of mental health treatment gap. Specifically, no prior brief, smartphone mindfulness ecological momenta…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Pennsylvania State University, University Park, Pennsylvania

    Run by

    Penn State University

    See if you can join NCT04846777 on ClinicalTrials.gov