Frailty Clinical Trials

22 studies are recruiting for frailty in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Longevity Metrics AI/ML Development Study

   This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy. Longevity Metrics collects a battery of clinical tests on each participant, in whole or in part, and follows every participant for life. The sit-to-rise tes…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07808619 on ClinicalTrials.gov

2. Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients.

   This research is being done to better understand the impact of the use of a specific physical activity training program (GH Method) in dialysis/kidney disease patients.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Illinois at Chicago, Chicago, Illinois

   Run by

   University of Illinois at Chicago

   See if you can join NCT06374537 on ClinicalTrials.gov

3. 100-Year Human Aging Study

   The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07563777 on ClinicalTrials.gov

4. Human Observatory Study

   The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07646782 on ClinicalTrials.gov

5. Health Ahead Comparative Effectiveness Study

   The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   William Brandenburg, MD

   See if you can join NCT07669168 on ClinicalTrials.gov

6. The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults

   The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and/or cognitive dysfunction. The main question[s] it aims to answer are: * To compare vascular function, oxidative stress levels, and physical and cognit…

   Stage

   Phase 2

   Ages

   65 to 80

   Site

   UConn Health, Farmington, Connecticut

   Run by

   UConn Health

   See if you can join NCT06027554 on ClinicalTrials.gov

7. Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

   Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07029243 on ClinicalTrials.gov

8. A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings

   Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent. Identifying functional impairments is essential for clinicians to provide optimal care to older adults, and on a population level, under…

   Stage

   Not phased

   Ages

   60 and older

   Site

   Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania

   Run by

   VA Office of Research and Development

   See if you can join NCT06404970 on ClinicalTrials.gov

9. Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

   The investigator proposes to conduct a randomized trial of supervised ambulation delivered by mobility technician (MT) up to three times daily, including weekends, to hospitalized medical patients. The aims of the study are to compare the short and intermediate-term outcomes of patients randomized …

   Stage

   Not phased

   Ages

   65 and older

   Site

   Baystate Medical Center, Springfield, Massachusetts

   Locations

   5 in total

   Run by

   The Cleveland Clinic

   See if you can join NCT05725928 on ClinicalTrials.gov

10. Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

    People with HIV experience earlier impairments in physical function compared to people in the general population. They also exhibit an earlier presentation and more rapid development of frailty, a multisystemic syndrome of aging characterized by reduced activity, fatigue, slowness, weakness, and we…

    Stage

    Phase 2

    Ages

    50 to 80

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06554717 on ClinicalTrials.gov

11. Occupational Therapy and Registered Dietitian Services to Reduce Fall Risk Among Home Delivered Meal Clients

    The purpose of this study is to determine which of the following four service models is most effective for reducing fall risk among home-delivered meal clients: (1) meals alone, (2) meals + registered dietitian services, (3) meals + occupational therapy services, (4) meals + registered dietitian + …

    Stage

    Not phased

    Ages

    60 and older

    Site

    LifeCare Alliance, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06586970 on ClinicalTrials.gov

12. Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults

    This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of a patented age-reversal therapy, EGA®, compared to conventional nicotinamide mononucleotide (NMN) supplementation. The study will assess safety and efficacy in improving exercise toler…

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Medical Office of Dr. Robert Huizenga MD, Beverly Hills, California

    Run by

    Scott Silveira

    See if you can join NCT07144527 on ClinicalTrials.gov

13. Precision Medicine and Physical Function

    The investigators aim to conduct a 12-week, single-arm, pre/post-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary outcomes of physical function and changes in multi-omics patterns, and…

    Stage

    Not phased

    Ages

    65 to 85

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT05877846 on ClinicalTrials.gov

14. Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

    Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degre…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT04717869 on ClinicalTrials.gov

15. Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future

    Durable left ventricular assist devices (dLVAD) have been increasingly utilized since the mid to late 1990s, with an uptick of utility starting in 2010 following expanded indications for therapy to not only include a bridge to transplantation strategy, but also for those individuals who suffer from…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCSF, San Francisco, California

    Locations

    7 in total

    Run by

    International Consortium of Circulatory Assist Clinicians

    See if you can join NCT06039176 on ClinicalTrials.gov

16. High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

    Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, de…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Kansas City VA Medical Center, Kansas City, MO, Kansas City, Missouri

    Locations

    2 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT05625204 on ClinicalTrials.gov

17. Auricular Acupressure in Prehabilitation

    Complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits. Acupuncture is among the most frequent types of complementary medicine practiced in the US, and Medicare currently includes back pa…

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06516198 on ClinicalTrials.gov

18. Get Fit for Function

    The purpose of this study will be to implement and evaluate a prehab program for pre-frail and frail adults who need to undergo thoracic surgery. The study team hypothesizes using an implementation framework will increase the reach, effectiveness, adoption, and implementation of the prehab program.

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06359652 on ClinicalTrials.gov

19. Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly

    Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy. Recently, investigators have noticed similar high rates of cancer control in small numbers of pat…

    Stage

    Not phased

    Ages

    65 to 99

    Site

    Baptist MD Anderson Cancer Center, Jacksonville, Florida

    Run by

    Omar Mahmoud

    See if you can join NCT06309225 on ClinicalTrials.gov

20. Prehabilitation for Kidney Transplant Candidates

    This interventional trial seeks to determine the feasibility of wearable sensors to provide data from patients while undergoing supervised exercise.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Houston Methodist Hospital System, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT06886256 on ClinicalTrials.gov

21. Meal Delivery and Exercise

    The purpose of this study is to evaluate the effects of a home-based exercise program administered through Meals on wheels (MOW) on gait speed and frailty status and to assess the association between novel serum biomarkers (70 kilodalton heat shock proteins (HSP70),Macrophage Inflammatory Proteins(…

    Stage

    Not phased

    Ages

    60 and older

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT04906759 on ClinicalTrials.gov

22. SCM Muscle as a Marker for Frailty in Patients Undergoing ENT Surgery

    This study focuses on evaluating the relationship between physical frailty and measurements of the muscles of the neck in patients undergoing non-cancer Head and Neck surgery.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai Hospital, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT06704256 on ClinicalTrials.gov