Fibromyalgia Clinical Trials

26 studies are recruiting for fibromyalgia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

   Fibromyalgia (FM) is a syndrome with clinical symptoms involving multiple systems. The efficacy of current treatments is inadequate, and more alternative modalities are needed for the management of FM patients. The parasympathetic vagus nerve innervates and integrates sensory, motor, and autonomic …

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06009159 on ClinicalTrials.gov

2. Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

   The study is a Phase 3, double-blind, placebo-controlled, randomized withdrawal study to assess the efficacy and safety of AXS-14 in the management of fibromyalgia.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Clinical Research Site, Glendale, Arizona

   Locations

   53 in total

   Run by

   Axsome Therapeutics, Inc.

   See if you can join NCT07398417 on ClinicalTrials.gov

3. Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

   The purpose of this study is to to explore the safety and efficacy of the EXOPULSE Mollii suit, a full-body electrostimulation suit, for individuals with neurological or neuromuscular conditions that cause spasticity, hyperreflexia, and/or pain.

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Shirley Ryan AbilityLab, Chicago, Illinois

   Run by

   Shirley Ryan AbilityLab

   See if you can join NCT07132775 on ClinicalTrials.gov

4. MDMA-assisted Therapy for Fibromyalgia

   Fibromyalgia is a debilitating chronic pain disorder. Based on prior research with MDMA, it can be hypothesized MDMA-assisted therapy in fibromyalgia patients may increase the range of positive emotions, interpersonal trust, and heighten the state of empathic rapport that can lead to an enhanced pa…

   Stage

   EARLY_Phase 1

   Ages

   21 to 65

   Site

   Massachusetts General Hospital, Charlestown, Massachusetts

   Run by

   Spaulding Rehabilitation Hospital

   See if you can join NCT06066853 on ClinicalTrials.gov

5. Ultrasonic Neuromodulation of Cingulate Cortex for Fibromyalgia

   The goal of this clinical trial is to evaluate a new noninvasive brain stimulation intervention for fibromyalgia and to determine its effectiveness in reducing pain. Participants will receive four treatments over the course of one month and will complete surveys at multiple time points throughout t…

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   8 in total

   Run by

   SPIRE Therapeutics Inc.

   See if you can join NCT07226648 on ClinicalTrials.gov

6. Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

   Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characteriz…

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05277025 on ClinicalTrials.gov

7. Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions

   The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations. This would enable objective assessment of pain and treatment in these populations and enable a much more precise approach to treatment. Such an en…

   Stage

   Not phased

   Ages

   5 to 21

   Site

   Children's National Health System, Washington D.C., District of Columbia

   Run by

   Children's National Research Institute

   See if you can join NCT04833465 on ClinicalTrials.gov

8. Effects of Breathing and Attention Training (BAT) on Pain Modulation

   The hypersensitivity of fibromyalgia is associated with abnormal pain modulation within the CNS, but not with peripheral or central sensitization. Many brain areas that contribute to modulation of pain are known, but their testing is complex and expensive. Quantitative sensory testing is easier to …

   Stage

   Not phased

   Ages

   18 to 70

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05773482 on ClinicalTrials.gov

9. The Effects of Core Shamanism in Fibromyalgia

   This study aims to determine the feasibility of a shamanism intervention for patients with fibromyalgia, acquire efficacy data to determine if Shamanism reduces clinical pain and other common symptoms associated with fibromyalgia, and determine if the Shamanism intervention changes heart rate elect…

   Stage

   Not phased

   Ages

   18 to 75

   Site

   Susan Samueli Integrative Health Institute, Irvine, California

   Run by

   University of California, Irvine

   See if you can join NCT06579261 on ClinicalTrials.gov

10. Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

    This study aims to see whether acupuncture can help fibromyalgia patients by giving them acupuncture treatment and seeing whether acupuncture helps enhance the effects of an opioid.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    UCI Health Susan Samueli Integrative Health Institute, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT06571110 on ClinicalTrials.gov

11. Vestibular Innovation in Pain 2

    Fibromyalgia is the most common centralized pain disorder, affecting up to 3% of the population. Current treatments are incompletely effective, often poorly tolerated, and costly: there remains an urgent need for novel, effective, and well-tolerated therapy. Preliminary data suggests that vestibulo…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mount Sinai West, New York, New York

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT07423377 on ClinicalTrials.gov

12. Supraspinal Processing of Sensory Aspects of Pain

    The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * …

    Stage

    Not phased

    Ages

    10 to 17

    Site

    Cincinnati Children's Hospital, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT05814497 on ClinicalTrials.gov

13. Fibromyalgia Sleep A to ZZZ Study

    This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06567886 on ClinicalTrials.gov

14. Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

    The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [F-18]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tr…

    Stage

    Phase 1

    Ages

    18 to 65

    Site

    University of Alabama at Birmingham Medical Center, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03759522 on ClinicalTrials.gov

15. Auricular Neuromodulation in Veterans With Fibromyalgia

    PENFS (percutaneous electrical nerve field stimulation) is an FDA-cleared acupuncture-like therapy applied to the external ear targeting several cranial nerve branches including the auricular branch of the vagus nerve to improve pain, physical function, and reduce symptoms of opioid withdrawal. PEN…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

    Run by

    VA Office of Research and Development

    See if you can join NCT06415591 on ClinicalTrials.gov

16. The BRIDGE Pain Study

    The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment. Aim 1. We want to…

    Stage

    Not phased

    Ages

    14 to 26

    Site

    Cincinnati Children's Hospital, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT07602595 on ClinicalTrials.gov

17. Neural Mechanisms of Light Driven Analgesia

    The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Run by

    University of North Carolina, Chapel Hill

    See if you can join NCT07245303 on ClinicalTrials.gov

18. Brief Pain Exposure Therapy (BPET) For Nociplastic Pain

    This study is intended to test whether a brief Zoom-based behavioral treatment can help adults with fibromyalgia (FM), Lupus, chronic pelvic pain, and chronic low back pain learn effective strategies for reducing pain, disability and other problems that can come with fibromyalgia, Lupus, chronic pe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06208514 on ClinicalTrials.gov

19. Self-regulation of Real-time fMRI Brain Activity in Chronic Pain

    This study aims to explore the usefulness of self-regulation of brain activity in patients with fibromyalgia. Patients will use real-time functional magnetic resonance imaging (fMRI) neurofeedback to observe and regulate their own brain activity while applying mental strategies to reduce fibromyalg…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT07023523 on ClinicalTrials.gov

20. Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia

    Fibromyalgia (FM) is a chronic pain condition that disproportionately impacts Veterans. Individuals diagnosed with FM patients experience lower self-esteem and positive affect, as well as greater levels of depression, anxiety, negative affect, and pain catastrophizing. Among those experiencing FM, …

    Stage

    Not phased

    Ages

    19 to 85

    Site

    Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama

    Run by

    VA Office of Research and Development

    See if you can join NCT06574165 on ClinicalTrials.gov

21. Cognitive Training to Enhance Brain Concordance During Acupuncture

    This study will evaluate the impact of a novel non-pharmacological multimodal therapy, a type of approach known to improve pain outcomes and recommended by the Institute of Medicine report for chronic pain management. This study design will also allow the investigators to evaluate a neural model su…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Charlestown, Massachusetts

    Locations

    3 in total

    Run by

    Spaulding Rehabilitation Hospital

    See if you can join NCT06157866 on ClinicalTrials.gov

22. The Effects of Energy Healing in Fibromyalgia

    This study aims to study the clinical effects of Energy Healing using fMRI and determine its application to Fibromyalgia patients. We also want to find out how active Energy Healing compares to sham Energy Healing in terms of brain connectivity and pain interference scores.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    University of California at Irvine, Irvine, California

    Run by

    University of California, Irvine

    See if you can join NCT06552728 on ClinicalTrials.gov

23. The Benefits of Natural Medicine, Vitamin IV Therapy and Supplements: Maintaining Good Health Through Nature

    Herbal Medicine is known as the medicinal use of herbal substances as a means of treating different conditions in the human body to ensure that the body remains in optimal health and wellness. These substances are known to contain very active ingredients in it and as such is also a very potent mean…

    Stage

    Not phased

    Ages

    21 to 80

    Site

    Health for Life Holistic Wellness Center LLC, Dover, Delaware

    Run by

    Faith A. Richardson

    See if you can join NCT05067998 on ClinicalTrials.gov

24. Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

    This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05754190 on ClinicalTrials.gov

25. Duloxetine Metabolism and Fibromyalgia

    People with fibromyalgia report generalized body pain ("pain all over"), increased sensitivity to painful stimulation, chronic tiredness or low energy, sleep problems, and other physical and functional problems. The exact cause of the disorder is poorly understood, and treatment can be difficult. T…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pain Management Center and Pain Research Center at the University of Utah, Salt Lake City, Utah

    Run by

    University of Utah

    See if you can join NCT06866444 on ClinicalTrials.gov