Fatigue Clinical Trials

26 studies are recruiting for fatigue in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue

   This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's abili…

   Stage

   Phase 2

   Ages

   34 to 80

   Site

   Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia

   Locations

   2 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT05584124 on ClinicalTrials.gov

2. A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

   This is a Phase 3, multicenter, randomized, double-blind, parallel-group, placebo-controlled clinical study to assess the efficacy and safety of HBS-301 in treating excessive daytime sleepiness (EDS), cataplexy, sleepiness/wakefulness, and fatigue in adult participants (ages ≥18 years) with narcole…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Phoenix Medical Group, PC, Peoria, Arizona

   Locations

   53 in total

   Run by

   Harmony Biosciences Management, Inc.

   See if you can join NCT07675135 on ClinicalTrials.gov

3. Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention

   The goal of this research study is to learn about the effects of the RISE-YA intervention on cancer-related fatigue in young adults who are brain cancer survivors.

   Stage

   Not phased

   Ages

   18 to 39

   Site

   The University of Texas M. D. Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT07186556 on ClinicalTrials.gov

4. Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

   The purpose of this research study is to better understand how cancer-related fatigue affects patients and how it's discussed with providers. This information will be used to develop an educational resource (visual aid poster) that could help individuals and their providers talk about cancer-relate…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Levine Childrens Hospital Pediatric Cancer and Blood Disorders, Charlotte, North Carolina

   Locations

   3 in total

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT06634381 on ClinicalTrials.gov

5. Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

   The primary objective of this study is to conduct a 16-week randomized controlled trial aimed at investigating the effectiveness of the Whole-Diet Approach when following a healthy US-style diet rich in anti-inflammatory properties. The study will focus on evaluating its impact on reducing symptoms…

   Stage

   Not phased

   Ages

   50 to 94

   Site

   University of Maryland, Baltimore, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT05977179 on ClinicalTrials.gov

6. Training in Evidence-based Treatments in Psycho-Oncology

   The goal of this research study is to train psychotherapists to administer individualized evidence-based psychotherapies in a cancer care setting to patients and caregivers with elevated levels of distress. The intervention will mirror clinical care in psycho-oncology in which the therapist, collab…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital Cancer Center, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05674357 on ClinicalTrials.gov

7. Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

   Cancer-related fatigue affects at least 30-90% of patients with cancer, depending on the type of cancer and their treatment(s) (e.g., chemotherapy, radiation). It is not relieved by sleep or rest, and it sometimes can persist for years after a person's cancer was treated. The fatigue can be so bad …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Maryland, Baltimore, Baltimore, Maryland

   Run by

   University of Maryland, Baltimore

   See if you can join NCT06482515 on ClinicalTrials.gov

8. Active Living After Cancer: Implementation Within Be Well Acres Homes

   The goal of this research study is to learn more about a physical activity program adapted for cancer survivors.

   Stage

   Not phased

   Ages

   18 and older

   Site

   The University of Texas M. D. Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT06907706 on ClinicalTrials.gov

9. Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

   Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vi…

   Stage

   Phase 2

   Ages

   21 to 85

   Site

   University of California Davis Health, Sacramento, California

   Locations

   2 in total

   Run by

   University of California, Davis

   See if you can join NCT04984226 on ClinicalTrials.gov

10. Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers

    To find out if combining psychoeducational interventions (such as education, counseling, and self-managed therapies) with an open-label placebo can help to improve your quality of life better than either the psychoeducational interventions or the placebo alone.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Centerr, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT06085716 on ClinicalTrials.gov

11. Virtual Patient Groups for Sarcoidosis Associated Fatigue

    This research study is testing whether Mindfulness-Based Stress Reduction (MBSR) can help reduce fatigue in people with sarcoidosis. The study will also look at whether MBSR can improve symptoms of anxiety and depression. Participants will be placed into one of two groups: * One group will take par…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT07073963 on ClinicalTrials.gov

12. Neuromodulation and Fatigue

    In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by up to 6 experimental sessions. Fatigability and motor fu…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    University of Oklahoma, Norman, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT05487131 on ClinicalTrials.gov

13. Transcranial Direct Current Stimulation for Post-stroke Fatigue

    The investigators hypothesize that delivery of anodal tDCS to the left frontal head region will reduce fatigue severity following stroke.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Weill Cornell Medicine, 525 E. 68th St, Baker Pavilion, F-2106, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05816603 on ClinicalTrials.gov

14. CF Wellness Program

    This study is a pilot randomized control trial (RCT; N=80) comparing the Cystic Fibrosis Wellness Program (CFWP) to usual care (UC) to evaluate (1) Intervention Adherence (completion of the CFWP Coaching Sessions) (2) Study Retention (completion of the Week 15 assessment) and (3) Data Quality (vali…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT07071324 on ClinicalTrials.gov

15. Exercise to ReGain Stamina and Energy (The EXERGISE Study)

    About 20%-70% of breast cancer survivors experience fatigue after cancer therapy. Because epidemiologic evidence shows that old age is a risk factor for fatigue in adults with cancer history, older breast cancer survivors suffer from even more fatigue than younger survivors. The purpose of this stu…

    Stage

    Not phased

    Ages

    60 to 105

    Site

    Institute on Aging; University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05684367 on ClinicalTrials.gov

16. Behavioral and Neural Representations of Subjective Effort Cost

    The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circ…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Kennedy Krieger Institute, Baltimore, Maryland

    Run by

    Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    See if you can join NCT04041154 on ClinicalTrials.gov

17. The Fit With Us Study

    The purpose of this 32-week study is to use an innovative experimental design known as SMART (Sequential Multiple Assignment Randomized Trial), which will allow us to determine the best way to sequence the delivery of teleexercise (referred to as an adaptive intervention), combined with predictive …

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Wellness, Health and Research Facility, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06207084 on ClinicalTrials.gov

18. Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

    The purpose of this study is to find out if taking a Fisetin supplement can decrease fatigue among older cancer survivors.

    Stage

    Phase 4

    Ages

    65 and older

    Site

    Atrium Health Wake Forest Baptist Hospital, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06819254 on ClinicalTrials.gov

19. Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

    This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individ…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Kennedy Krieger Institute, Baltimore, Maryland

    Run by

    Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

    See if you can join NCT07278388 on ClinicalTrials.gov

20. Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus

    The goal of this study is to learn about the safety of Niagen®Plus, an injectable form of nicotinamide riboside (NR), and to see how it affects levels of NAD+ in the blood. Niagen®Plus will be given either by subcutaneous (under the skin) or intramuscular (into the muscle) injection at two dose lev…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    BTT Medical Institute Aventura North, Miami, Florida

    Run by

    ChromaDex, Inc.

    See if you can join NCT07251608 on ClinicalTrials.gov

21. Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

    To learn if Cognitive Behavior Therapy (called CBT), combined with either Bright Light Therapy (called BLT), methylphenidate, and/or melatonin, can help improve sleep and other related symptoms such as fatigue, anxiety, and depression in cancer patients. This is an investigational study. In this st…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05474846 on ClinicalTrials.gov

22. Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management

    The long-term goal of this project is to improve the implementation of tailored resistance exercise interventions for Appalachian breast cancer survivors. To achieve this goal, the primary objective is to enhance the understanding of how biological, psychological, and social factors interact to inf…

    Stage

    Not phased

    Ages

    18 and older

    Site

    West Virginia University, Morgantown, West Virginia

    Run by

    West Virginia University

    See if you can join NCT06960720 on ClinicalTrials.gov

23. Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

    This research study is being done to investigate if the GH Method exercise program positively affects body composition, improves physical abilities and can improve the overall sense of wellbeing (e.g. depression, PTSD, etc.) in U.S. Veterans. Subjects will be asked to complete 94 total visits (four…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT05094297 on ClinicalTrials.gov

24. A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).

    The goal of this clinical trial is to study the impact of Dyanavel on co-occuring fatigue in adults with Attention Deficit/Hyperactivity Disorder. The main question it aims to answer is whether Dyanavel XR leads to a statistically significant reduction in fatigue compared to placebo, as measured by…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Rochester Center for Behavioral Medicine, Rochester Hills, Michigan

    Run by

    Rochester Center for Behavioral Medicine

    See if you can join NCT06248229 on ClinicalTrials.gov

25. Eccentric Exercise and Fatigue in Multiple Sclerosis

    The goal of this observational study is to compare the impact of eccentric resistance training to traditional resistance training on fatigue in persons with multiple sclerosis (MS). The primary question this study is asking is the following: is eccentric resistance training more fatiguing than trad…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Hunter College, Physical Therapy Department, City University of New York, New York, New York

    Run by

    Hunter College of City University of New York

    See if you can join NCT06505421 on ClinicalTrials.gov