Essential Tremor Clinical Trials

25 studies are recruiting for essential tremor in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease

   Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to age-matched populations, with approximately 1% converting to PD annually. Po…

   Stage

   Not phased

   Ages

   50 to 85

   Site

   CND Clinical Research Center, Scottsdale, Arizona

   Locations

   4 in total

   Run by

   CND Life Sciences

   See if you can join NCT07428447 on ClinicalTrials.gov

2. Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor

   The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT01734122 on ClinicalTrials.gov

3. 3-D Tractography FUS Ablation for Essential Tremor

   The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain. The investigators hypothesize that 3-D tractography Vim-FUSA will improve th…

   Stage

   Not phased

   Ages

   22 and older

   Site

   University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

   Run by

   University of North Carolina, Chapel Hill

   See if you can join NCT06331052 on ClinicalTrials.gov

4. Deep Brain Stimulation (DBS) Retrospective Outcomes Study

   The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.

   Stage

   Not phased

   Ages

   Any age

   Site

   St. Joseph's Hospital & Medical Center, Phoenix, Arizona

   Locations

   20 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT03664609 on ClinicalTrials.gov

5. Deep Brain Stimulation Surgery for Movement Disorders

   Background: - Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments. DBS uses a battery-powered device called a neurostimulator (like a pacemaker) that is placed under the skin in the chest. It is u…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT01581580 on ClinicalTrials.gov

6. Physiological Brain Atlas Development

   The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

   Stage

   Not phased

   Ages

   6 to 90

   Site

   Vanderbilt Univeristy, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT00575081 on ClinicalTrials.gov

7. Circadian Adaptive DBS in Essential Tremor

   Deep brain stimulation (DBS) of the thalamus is an effective treatment for medically refractory essential tremor (ET). DBS involves delivering continuous stimulation to the brain through electrodes permanently implanted in the thalamus. Despite proven effectiveness, the long-term benefit of DBS can…

   Stage

   Not phased

   Ages

   21 to 89

   Site

   Norman Fixel Institute for Neurological Diseases, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06635811 on ClinicalTrials.gov

8. Motor Network Physiology

   The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks. Deep brain stimulation is a treatment that is used to treat these types of n…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   UT Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT04957095 on ClinicalTrials.gov

9. Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

   This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System. The population will consist of patients that have either failed a prior intervention (Vi…

   Stage

   Phase 1

   Ages

   21 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07049003 on ClinicalTrials.gov

10. Coordinated Reset Deep Brain Stimulation for Essential Tremor

    Deep brain stimulation (DBS) is a surgical procedure for the treatment of Essential Tremor (ET). A novel approach to current DBS approaches is called coordinated reset DBS (CR-DBS) which uses different patterns of stimulation at lower currents and can address the limitations of traditional DBS that…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT05897775 on ClinicalTrials.gov

11. Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor

    This open-label pilot study will evaluate the safety, tolerability, feasibility, and preliminary efficacy of repeated low-intensity focused ultrasound pulsation (LIFUP) targeting the ventral intermediate nucleus (Vim) of the thalamus in patients with Essential Tremor (ET). Twelve adults with clinic…

    Stage

    EARLY_Phase 1

    Ages

    18 to 90

    Site

    UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT07599592 on ClinicalTrials.gov

12. Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor

    The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor. Participants will either 1) have electroencephalography (EEG) scalp electrodes placed, or 2) remain seat…

    Stage

    Not phased

    Ages

    30 to 80

    Site

    Cleveland Clinic, Cleveland, Ohio

    Run by

    The Cleveland Clinic

    See if you can join NCT06293638 on ClinicalTrials.gov

13. Attention and Eye Movement in Parkinson's Disease

    The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement disorders, including essential tremor (ET) and dystonia (DT). The main …

    Stage

    Not phased

    Ages

    19 to 90

    Site

    University of Nebraska Medical Center, Omaha, Nebraska

    Run by

    University of Nebraska

    See if you can join NCT06899022 on ClinicalTrials.gov

14. Magnetoencephalography (MEG) Pilot Study

    The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU). Essential tremor is a movement disorder that causes shaking, usually in the hands, and can make everyday tasks d…

    Stage

    Not phased

    Ages

    50 to 84

    Site

    UF Health, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07446192 on ClinicalTrials.gov

15. Cortical-Basal Ganglia Speech Networks

    In this research study the researchers want to learn more about brain activity related to speech perception and production.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04286308 on ClinicalTrials.gov

16. Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

    This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech sequences. Participants will include two groups: 1. individuals with Parkinso…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston University, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston University Charles River Campus

    See if you can join NCT07455760 on ClinicalTrials.gov

17. Ultrasound Neuromodulation in Essential Tremor

    This study is being done to test whether low-intensity focused ultrasound (LIFU) (low energy sound waves) cause temporary changes in brain activity and behavior when directed at particular parts of the brain. By targeting LIFU to the parts of the brain thought to be responsible for essential tremor…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pritzker Building, UCSF, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06610877 on ClinicalTrials.gov

18. Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor

    This is a feasibility study based on physician-initiated Investigational Device Exemption (IDE) including intraoperative experiments and chronic testing of implanted dual thalamic DBS lead systems. This study will inform protocols for optimal use of implanted next-gen DBS systems for primarily trem…

    Stage

    Not phased

    Ages

    21 to 99

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT04212780 on ClinicalTrials.gov

19. Algorithms for Programming DBS Systems for ET

    Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET). The success of this treatment, however, is highly dependent on the ability of clinici…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT03984643 on ClinicalTrials.gov

20. Abbott DBS Post-Market Study of Outcomes for Indications Over Time

    The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of South Florida - Department of Neurology, Tampa, Florida

    Locations

    48 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT04071847 on ClinicalTrials.gov

21. Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

    This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT05317390 on ClinicalTrials.gov

22. Home Use Study of Targeted Mechanical Stimulation for Tremor Relief

    Subjects will receive prototype devices to be used for participation. The study comprises three phases: 1. Alpha phase: Two remote study visits and an in-home period to gather device usability data on the alpha system. The at home period for this phase will be 2 weeks. This phase will be used to co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Encora Therapeutics, Cambridge, Massachusetts

    Run by

    Encora, Inc.

    See if you can join NCT07078422 on ClinicalTrials.gov

23. Directional Versus Nondirectional DBS for ET

    This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT04828798 on ClinicalTrials.gov

24. Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract

    The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation

    Stage

    Not phased

    Ages

    18 to 85

    Site

    North Shore University Hospital, Manhasset, New York

    Run by

    Northwell Health

    See if you can join NCT04758624 on ClinicalTrials.gov

25. Clinical Outcomes for Deep Brain Stimulation

    The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits, and complications.

    Stage

    Not phased

    Ages

    Any age

    Site

    Washington University in St Louis, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT03992625 on ClinicalTrials.gov