Esophageal Cancer Clinical Trials

66 studies are recruiting for esophageal cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 3

1. cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

   This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gast…

   Stage

   Not phased

   Ages

   40 and older

   Site

   City of Hope, Duarte, California

   Locations

   17 in total

   Run by

   Adela, Inc

   See if you can join NCT05366881 on ClinicalTrials.gov

2. Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

   The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Lumicell, Inc.

   See if you can join NCT02584244 on ClinicalTrials.gov

3. A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors

   The goal of this clinical trial is to evaluate whether TJ101, an investigational antibody-drug conjugate (ADC), can safely and effectively treat patients with advanced solid tumors. The main objectives of this study are : * To Determine the maximum tolerated dose (MTD) and recommended dose for expa…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Florida Cancer Specialists & Research Institute, Orlando, Florida

   Locations

   7 in total

   Run by

   Phrontline Biopharma

   See if you can join NCT07181473 on ClinicalTrials.gov

4. Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma

   Our research of the biology of upper gastrointestinal cancers involves the study of tissue samples and cells from biopsies of persons with gastric or esophageal cancer or blood samples from upper gastrointestinal cancer patients and persons at high inherited risk for these cancers. We hope to learn…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Stanford University School of Medicine, Stanford, California

   Run by

   Stanford University

   See if you can join NCT01048281 on ClinicalTrials.gov

5. EsophaCap for the Detection of Early Esophageal Carcinoma

   This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma), and gastric cancer via sponge cytology.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Bayview Medical Center, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT04214119 on ClinicalTrials.gov

6. VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

   This is a multicenter, open-label, Phase 1/2 study of orally administered VMD-928 monotherapy and in combination with pembrolizumab in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curat…

   Stage

   Phase 1

   Ages

   18 to 80

   Site

   Providence Medical Foundation (site 209), Santa Rosa, California

   Locations

   15 in total

   Run by

   VM Oncology, LLC

   See if you can join NCT03556228 on ClinicalTrials.gov

7. A Study of MT-4561 in Patients With Various Advanced Solid Tumors

   This is a First In Human (FIH), multicenter, open-label, Phase I/II study to evaluate safety, tolerability, Pharmacokinetics (PK), pharmacodynamics, and efficacy of MT-4561 in patients with advanced solid tumors. This study will be conducted in 3 parts. Part 1 is aimed at evaluating safety, tolerab…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Southern California, Los Angeles, California

   Locations

   6 in total

   Run by

   Tanabe Pharma America, Inc.

   See if you can join NCT06943521 on ClinicalTrials.gov

8. Exercise Prehabilitation for Locoregional Esophageal Cancer

   The purpose of the study is to examine the feasibility and acceptability of exercise "prehabilitation" for patients preparing for esophageal cancer resection (removal).

   Stage

   Not phased

   Ages

   18 and older

   Site

   Moffitt Cancer Center, Tampa, Florida

   Run by

   H. Lee Moffitt Cancer Center and Research Institute

   See if you can join NCT06430346 on ClinicalTrials.gov

9. Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

   Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery. Also, early detection of lung cancer with low dose CT screening may cure patients at an early stage. Circulating and disseminated…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Harry S Truman Veterans Memorial Hospital, Columbia, Missouri

   Run by

   University of Missouri-Columbia

   See if you can join NCT03551951 on ClinicalTrials.gov

10. Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

    RATIONALE: Studying samples of sputum and tissue in the laboratory from patients with dysplasia or cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help the study of cancer in the future. PURPOSE: This laboratory study is looking at biomarkers in patie…

    Stage

    Not phased

    Ages

    21 to 90

    Site

    University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT00900419 on ClinicalTrials.gov

11. Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

    This is an open-label study in adults to determine feasibility of using CYTALUX™ (pafolacianine) injection with near-infrared (NIR) fluorescent imaging for detecting any type adenocarcinoma (gastric, esophageal and appendiceal).

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT07124351 on ClinicalTrials.gov

12. Pan-tumor MRD Study

    The purpose of this observational study is to collect clinical information, blood, and tumor tissue samples from participants diagnosed with stage I, stage II, or operable stage III cancer in select solid tumors. The information collected will be used to develop tests to better understand cancer, f…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical Oncology Associates of San Diego, San Diego, California

    Locations

    2 in total

    Run by

    Paradigm Health

    See if you can join NCT06605404 on ClinicalTrials.gov

13. 64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

    This is a multicenter, open-label, prospective Phase 1/2a study to assess safety and tolerability, establish dosimetry and to identify an optimal imaging dose (radioactivity) and imaging time window of 64Cu-LNTH-1363S, and to compare its imaging biodistribution with FAP expression by IHC in patient…

    Stage

    Phase 1

    Ages

    15 and older

    Site

    City of Hope, Duarte, California

    Locations

    5 in total

    Run by

    Lantheus Medical Imaging

    See if you can join NCT06298916 on ClinicalTrials.gov

14. A Beta-only IL-2 ImmunoTherapY Study

    This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a checkpoint inhibitor in patients with advanced solid tumors.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Sharp Memorial Hospital, San Diego, California

    Locations

    27 in total

    Run by

    Medicenna Therapeutics, Inc.

    See if you can join NCT05086692 on ClinicalTrials.gov

15. Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

    This research study aims to evaluate the safety and determine the optimal dose of a new experimental drug, vvDD-hIL2 (vaccinia virus double-deleted human interleukin 2), in patients with advanced abdominal cancer. The study will involve three dose levels, with three to six patients enrolled at each…

    Stage

    Phase 1

    Ages

    18 to 69

    Site

    AHN West Penn Hospital, Pittsburgh, Pennsylvania

    Run by

    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT07001592 on ClinicalTrials.gov

16. TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

    A prospective outcomes study in patients with and esophageal cancer (EAC) and Barrett's esophagus (BE) associated neoplasia being evaluated for endoscopic eradication therapy (EET).

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UCLA Medical Center, Los Angeles, California

    Locations

    4 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT02634645 on ClinicalTrials.gov