Endothelial Dysfunction Clinical Trials

22 studies are recruiting for endothelial dysfunction in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research

   Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine. Blood samples may also be collected to make special cells. These are called induced plurip…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institutes of Health Clinical Center (CC)

   See if you can join NCT03253705 on ClinicalTrials.gov

2. ACEs, SIRT1, and Premature Vascular Aging in Humans

   Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2]. Previous work from our lab (IRB 202010095) and others [3] demonstrate…

   Stage

   Not phased

   Ages

   18 to 30

   Site

   Department of Kinesiology, University of Wisconsin, Madison, Wisconsin

   Locations

   2 in total

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07073352 on ClinicalTrials.gov

3. Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

   The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e. dulaglutide) enhances insulin-mediated skeletal muscle microvascular perfusion via attenuating endothelial oxidative stress and thereby improving endothelia…

   Stage

   Phase 2

   Ages

   18 to 40

   Site

   AdventHealth Translational Research Institute, Orlando, Florida

   Run by

   AdventHealth Translational Research Institute

   See if you can join NCT05478707 on ClinicalTrials.gov

4. SGC Stimulation, Perioperative Vascular Reactivity, and Organ Injury in Cardiac Surgery

   The goal of this mechanistic clinical trial is to learn about the effects of medications called soluble guanylyl cyclase stimulators on vascular function and markers of kidney and brain injury in patients having heart surgery. The main questions it aims to answer are: 1. Does soluble guanylyl cycla…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Vanderbilt University Medical Center, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT05812755 on ClinicalTrials.gov

5. Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM

   Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy. While subsequent development of type II diabetes elevates this risk, prior GDM is an independent risk factor for CVD m…

   Stage

   EARLY_Phase 1

   Ages

   18 to 50

   Site

   University of Iowa, Iowa City, Iowa

   Run by

   Anna Stanhewicz, PhD

   See if you can join NCT06547619 on ClinicalTrials.gov

6. Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans

   Specific Aim 1: To test the hypothesis that prolonged (3-month) treatment with galantamine inhibits NADPH IsoLG-protein adducts formation and improves markers of endothelial cell (EC) dysfunction in AAs. Aim 1a: The investigators will determine if galantamine inhibits NADPH IsoLG-protein adducts fo…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Chaney Johnson, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT04769206 on ClinicalTrials.gov

7. EndoPAT Device for Endothelial Dysfunction in ED

   To assess endothelial dysfunction in young men (aged 30-50) with vasculogenic ED identified through penile Doppler ultrasound. To evaluate changes in endothelial function using EndoPAT before and 3-6 months after daily low-dose phosphodiesterase type 5 (PDE5) inhibitor therapy. To investigate endot…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCI Urology | Men's Health Center, Newport Beach, California

   Run by

   University of California, Irvine

   See if you can join NCT06720597 on ClinicalTrials.gov

8. Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

   High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women. In adults age ≥50 years this risk is primarily driven by above-normal systolic BP (SBP ≥120 mmHg), as diastolic BP plateaus, th…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Integrative Physiology of Aging Laboratory, Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT05000515 on ClinicalTrials.gov

9. Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

   The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007. Prevalence of ever and current e-cigarette use is highest among teenagers and young adults wi…

   Stage

   EARLY_Phase 1

   Ages

   18 to 24

   Site

   Iowa Bioscience Innovation Facility, Iowa City, Iowa

   Locations

   2 in total

   Run by

   University of Iowa

   See if you can join NCT06489249 on ClinicalTrials.gov

10. Microvascular Dysfunction in Obesity

    Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-o…

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT04087655 on ClinicalTrials.gov

11. The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

    The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function. In Aim 1 (The Iowa ACEs and Sleep Cohort Study), the investigators will utilize a cro…

    Stage

    Not phased

    Ages

    18 to 29

    Site

    Integrative Laboratory of Applied Physiology and Lifestyle Medicine, Iowa City, Iowa

    Run by

    Nathaniel Jenkins

    See if you can join NCT06454344 on ClinicalTrials.gov

12. Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury

    Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly unde…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT07227740 on ClinicalTrials.gov

13. Endothelial Dysfunction After SCI

    This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT07227727 on ClinicalTrials.gov

14. Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

    The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of exercise. Participants will come in for 3 study visits and get home-bas…

    Stage

    Phase 2

    Ages

    65 to 85

    Site

    Froedtert Hospital, Wauwatosa, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05808686 on ClinicalTrials.gov

15. NightWare and Cardiovascular Health in Veterans With PTSD

    The purpose of this study is to learn more about the effectiveness of a prescription wrist-wearable device called NightWare (NW) on improving sleep in Veterans with nightmares related to posttraumatic stress disorder (PTSD). The investigators also want to learn whether it improves cardiovascular he…

    Stage

    Not phased

    Ages

    22 to 88

    Site

    Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado

    Run by

    VA Office of Research and Development

    See if you can join NCT06419959 on ClinicalTrials.gov

16. MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

    Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range. Yet, type 1 diabetes is a complex disease with pathophysiology that exten…

    Stage

    Phase 1

    Ages

    12 to 25

    Site

    Seattle Children's Hospital, Seattle, Washington

    Locations

    2 in total

    Run by

    Kalie Tommerdahl

    See if you can join NCT05065372 on ClinicalTrials.gov

17. Puberty Suppression and Cardiometabolic Health

    This observational study will evaluate the effect of puberty suppression on insulin sensitivity, metabolic rate and vascular health among transgender female youth at baseline and 6 months after initiation of a gondoatropin releasing hormone agonist compared to matched cisgender male controls.

    Stage

    Not phased

    Ages

    9 to 14

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04482374 on ClinicalTrials.gov

18. B-Complex: A Nutraceutical SANS Countermeasure

    In this project, the investigators propose to test effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts. The proposed countermeasure is intended to maximize functioning of the one-carbon metabolic pathway to provide enough subs…

    Stage

    Phase 1

    Ages

    20 to 100

    Site

    Johnson Space Center, Houston, Texas

    Run by

    National Aeronautics and Space Administration (NASA)

    See if you can join NCT05366933 on ClinicalTrials.gov

19. Bright Light Exposure in Surgical Patients

    1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I level…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    University of Colorado Denver | Anschutz Medical Campus, Denver, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03822949 on ClinicalTrials.gov

20. Sodium Lowering Vascular Effects Trial

    The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension. Findings from this study will fill the knowledge gap on the underlying mechanisms of dietary sodium intake on cardiov…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Tulane University Office of Health Research, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT05388032 on ClinicalTrials.gov

21. Optimizing Pulsatility During Cardiopulmonary Bypass

    Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs. Blood flow during cardiopulmonary bypass may be pulsatile or non-pulsatile, which may impact normal organ function after surgery. The study will collect data on …

    Stage

    Not phased

    Ages

    50 to 70

    Site

    University of Colorado Hospital, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT05344573 on ClinicalTrials.gov

22. Role of Endothelial Function in SCI CVD Risk

    Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diab…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Craig Hospital, Englewood, Colorado

    Run by

    Craig Hospital

    See if you can join NCT06443151 on ClinicalTrials.gov