Endometriosis Clinical Trials

25 studies are recruiting for endometriosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Personalized Exercise Recommendations for Chronic Pelvic Pain Using Reinforcement Learning

   WorkoutCPP is a pilot study evaluating the feasibility of a personalized exercise recommendation system for individuals with chronic pelvic pain disorders (CPPDs). The study uses reinforcement learning (RL), a type of artificial intelligence that adapts recommendations over time based on each parti…

   Stage

   Not phased

   Ages

   18 to 55

   Site

   Icahn School of Medicine at Mount Sinai, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT07810218 on ClinicalTrials.gov

2. Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer

   This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shri…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Locations

   3 in total

   Run by

   Mayo Clinic

   See if you can join NCT04567771 on ClinicalTrials.gov

3. Endometriosis and Microvascular Dysfunction: Role of Inflammation

   The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data …

   Stage

   EARLY_Phase 1

   Ages

   18 to 45

   Site

   The Pennsylvania State University, University Park, Pennsylvania

   Run by

   Penn State University

   See if you can join NCT05069740 on ClinicalTrials.gov

4. Assessing the Mechanisms and Impact of a Novel Cannabinoid Product for Gynecologic Pain

   Despite recent increases in both medical and recreational cannabis use in the United States and globally, little research has been conducted to determine the potential applications for womens health. A variety of medical cannabis and hemp-derived products on the marketplace claim to hold efficacy f…

   Stage

   Phase 1

   Ages

   21 and older

   Site

   McLean Hospital, Belmont, Massachusetts

   Run by

   Staci Gruber, Ph.D.

   See if you can join NCT07728695 on ClinicalTrials.gov

5. Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

   Despite the proliferation of cannabis and cannabinoid products in recent years, little research has been done to determine the impact of these products on womens health conditions, including endometriosis. This study is designed to assess the impact of a custom-formulated, hemp-derived, full-spectr…

   Stage

   Phase 2

   Ages

   21 and older

   Site

   McLean Hospital, Belmont, Massachusetts

   Run by

   Mclean Hospital

   See if you can join NCT06477406 on ClinicalTrials.gov

6. Endometriosis Pain

   Aim 1. To determine the factors contributing to pain in patients with chronic pelvic pain with and without endometriosis Aim 2. To determine the changes following endometriosis lesion removal surgery in pain and sex hormone levels. Aim 3. To identify factors predicting clinical pain reduction after…

   Stage

   Not phased

   Ages

   12 to 45

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06101303 on ClinicalTrials.gov

7. Endometriosis and Migraine

   This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples…

   Stage

   Not phased

   Ages

   12 to 45

   Site

   Washington University School of Medicine, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06785129 on ClinicalTrials.gov

8. CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life

   This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program * a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work …

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Alethios Digital Research Platform (Decentralized), San Francisco, California

   Run by

   Samphire Group, Inc.

   See if you can join NCT07679074 on ClinicalTrials.gov

9. The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial

   The goal of this investigator-initiated single-site clinical trial is to compare the overall quality of life of participants taking Relugolix combination therapy (Rel-CT) following excisional surgery for endometriosis to participants that do not take Rel-CT following the same surgery. Rel-CT is an …

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Main Line Health, Wynnewood, Pennsylvania

   Run by

   Main Line Health

   See if you can join NCT06439524 on ClinicalTrials.gov

10. Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck)

    The goal of this observational study is to determine the clinical validity of a deep neural network algorithm that utilizes protein biomarker detection of Endometriosis - "EndoCheck" - as an "aid in diagnosis" for endometriosis and to show validity as a diagnostic test

    Stage

    Not phased

    Ages

    14 to 50

    Site

    New Horizons Clinical Trials, Chandler, Arizona

    Locations

    10 in total

    Run by

    Aspira Women's Health

    See if you can join NCT05245695 on ClinicalTrials.gov

11. The Impact of Yoga on Endometriosis-Related Pain

    The central hypothesis of the investigators is that the practice of yoga will result in an improvement of endometriosis related pain symptoms for women with endometriosis.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Penn State Health, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT06559852 on ClinicalTrials.gov

12. Impact of Pelvic Pain Podcast

    The purpose of this research study is to study the impact of an educational podcast on pelvic pain. If you decide to take part in this research, you may receive the standard treatment for pelvic pain, or you may receive the standard treatment plus access to an educational podcast series. You will b…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Vanderbilt Center for Women's Health, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT07568834 on ClinicalTrials.gov

13. Stanford Program to Accelerate Robotic Children's Surgery

    The goal of this clinical trial is to provide additional data to confirm safety and performance of the da Vinci Xi Surgical System in a human clinical setting. This pilot study is intended to provide an initial assessment to evaluate the feasibility, safety, and effectiveness for the utilization of…

    Stage

    Not phased

    Ages

    6 to 21

    Site

    Lucile Packard Children's Hospital Stanford, Stanford, California

    Run by

    Stanford University

    See if you can join NCT06671639 on ClinicalTrials.gov

14. A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis

    This randomized, controlled study will investigate the efficacy of a dietary intervention for women with endometriosis. Participants will be randomly assigned to follow a whole food plant-based (intervention) diet or stay on their usual (control) diet for 12 weeks.

    Stage

    Not phased

    Ages

    18 to 45

    Site

    UCSD Health, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07090096 on ClinicalTrials.gov

15. Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

    The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

    Stage

    Not phased

    Ages

    18 to 45

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT06847685 on ClinicalTrials.gov

16. Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain

    The purpose of this study is to better understand how hormone suppression with Relugolix Combination-Therapy (CT) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis associated pelvic pain.

    Stage

    Phase 3

    Ages

    18 to 49

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT07100782 on ClinicalTrials.gov

17. Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

    The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related neuroinflammatory conditions. Participants in the United States aged 2 years…

    Stage

    Not phased

    Ages

    2 and older

    Site

    Brain Inflammation Collaborative, Delafield, Wisconsin

    Run by

    Brain Inflammation Collaborative

    See if you can join NCT04806620 on ClinicalTrials.gov

18. Interdisciplinary Group Care for the Treatment of Endometriosis-associated Pain

    The goal of this clinical trial is to determine if Peer Empowered Endometriosis Pain Support (PEEPS), an 8-week interdisciplinary, integrative group care program, decreases pain interference in participants with endometriosis-associated chronic pelvic pain between the ages 18 and 48. The main quest…

    Stage

    Not phased

    Ages

    18 to 48

    Site

    WashU Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06549985 on ClinicalTrials.gov

19. Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups

    The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main…

    Stage

    Not phased

    Ages

    22 to 45

    Site

    Alethios, Inc., San Francisco, California

    Run by

    Samphire Group, Inc.

    See if you can join NCT06974773 on ClinicalTrials.gov

20. Feasibility of a Mindfulness Intervention for Endometriosis Surgery

    Endometriosis is a common cause of pelvic pain in women which has been historically under-studied and under-diagnosed. The goal of this research is to pilot-test the feasibility and acceptability of a manualized, single-session brief mindfulness-based intervention (BMBI) among participants with end…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Penn State Health, Hershey, Pennsylvania

    Run by

    Milton S. Hershey Medical Center

    See if you can join NCT06141720 on ClinicalTrials.gov

21. Physical Therapy After Endometriosis Excision

    This is a randomized controlled pilot study comparing a home pelvic floor physical therapy program to routine post-operative care for patients undergoing endometriosis excisional surgery without hysterectomy. Quality of life and endometriosis symptoms will be compared following the recovery period.

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT07127783 on ClinicalTrials.gov

22. A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis

    The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in premenopausal women with heavy menstrual bleeding associated with uterine leiomyom…

    Stage

    Phase 3

    Ages

    18 to 50

    Site

    Mobile, Mobile, Alabama

    Locations

    120 in total

    Run by

    Sumitomo Pharma Switzerland GmbH

    See if you can join NCT05862272 on ClinicalTrials.gov

23. Cardiovascular Disease Risk in Women With Endometriosis

    To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.

    Stage

    EARLY_Phase 1

    Ages

    18 to 45

    Site

    Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT03746535 on ClinicalTrials.gov

24. Histologic Comparison of Ablative Techniques for Endometriosis

    To our knowledge, no other human studies directly compare the effectiveness of the various ablative technologies. We set out to design a study to directly compare ablative energy sources and evaluate their ability to destroy native endometriosis tissue in humans.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Good Samaritan Hospital, Cincinnati, Ohio

    Run by

    TriHealth Inc.

    See if you can join NCT06414083 on ClinicalTrials.gov

25. Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers

    This study is testing a way to diagnose endometriosis using a uterine tissue biopsy (similar to a pap smear) as opposed to undergoing laparoscopy surgery. The tissue is sent to lab for cellular analysis with a proprietary AI (artificial intelligence) technology.

    Stage

    Phase 2

    Ages

    18 to 50

    Site

    Corpus Christi Women's Center, Corpus Christi, Texas

    Locations

    3 in total

    Run by

    Hera Biotech, Inc.

    See if you can join NCT05698212 on ClinicalTrials.gov