Dystonia Clinical Trials

15 studies are recruiting for dystonia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia

   Stride Dystonia is a randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of VIM0423 in individuals with isolated dystonia. The main objectives of this clinical trial are to determine the following: * Does VIM0423 therapy improve dystonia symptoms co…

   Stage

   Phase 2

   Ages

   18 to 70

   Site

   Vima Site #033, Birmingham, Alabama

   Locations

   38 in total

   Run by

   Vima Therapeutics

   See if you can join NCT07304089 on ClinicalTrials.gov

2. Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

   The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the e…

   Stage

   Not phased

   Ages

   6 to 21

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT07325175 on ClinicalTrials.gov

3. Deep Brain Stimulation (DBS) Retrospective Outcomes Study

   The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.

   Stage

   Not phased

   Ages

   Any age

   Site

   St. Joseph's Hospital & Medical Center, Phoenix, Arizona

   Locations

   20 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT03664609 on ClinicalTrials.gov

4. Deep Brain Stimulation Surgery for Movement Disorders

   Background: - Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments. DBS uses a battery-powered device called a neurostimulator (like a pacemaker) that is placed under the skin in the chest. It is u…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Neurological Disorders and Stroke (NINDS)

   See if you can join NCT01581580 on ClinicalTrials.gov

5. Physiological Brain Atlas Development

   The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essentia…

   Stage

   Not phased

   Ages

   6 to 90

   Site

   Vanderbilt Univeristy, Nashville, Tennessee

   Run by

   Vanderbilt University Medical Center

   See if you can join NCT00575081 on ClinicalTrials.gov

6. Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy

   This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this is impacted by a person's genetics. Information from this study will …

   Stage

   Phase 1

   Ages

   5 to 17

   Site

   Children's Mercy Hospital Kansas City, Kansas City, Missouri

   Run by

   Children's Mercy Hospital Kansas City

   See if you can join NCT06554288 on ClinicalTrials.gov

7. Cortical-Basal Ganglia Speech Networks

   In this research study the researchers want to learn more about brain activity related to speech perception and production.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT04286308 on ClinicalTrials.gov

8. A Multicenter Pediatric Deep Brain Stimulation Registry

   There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies adequately. This study aims to develop a multicenter pediatric DBS registry tha…

   Stage

   Not phased

   Ages

   0 to 18

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT06585618 on ClinicalTrials.gov

9. Sleep-specific DBS Therapy in Parkinson's Disease

   Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of thera…

   Stage

   Not phased

   Ages

   21 and older

   Site

   University Of Minnesota, Minneapolis, Minnesota

   Run by

   University of Minnesota

   See if you can join NCT05962489 on ClinicalTrials.gov

10. Abbott DBS Post-Market Study of Outcomes for Indications Over Time

    The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling tremor and dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    University of South Florida - Department of Neurology, Tampa, Florida

    Locations

    48 in total

    Run by

    Abbott Medical Devices

    See if you can join NCT04071847 on ClinicalTrials.gov

11. Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

    The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Massachusetts General Hospital, University of California San Francisco, University of Utah, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT05150093 on ClinicalTrials.gov

12. Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia

    This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.

    Stage

    Not phased

    Ages

    Any age

    Site

    Massachusetts Eye and Ear Infirmary, Boston, Massachusetts

    Run by

    Massachusetts Eye and Ear Infirmary

    See if you can join NCT05317390 on ClinicalTrials.gov

13. Effects of Exercise on Dystonia Pathophysiology

    The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.

    Stage

    Not phased

    Ages

    30 to 85

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT05663840 on ClinicalTrials.gov

14. Dystonia Genotype-Phenotype Correlation

    The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to (3) collect DNA, detailed family history, and clinical phenotypes from…

    Stage

    Not phased

    Ages

    11 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT03428009 on ClinicalTrials.gov

15. Clinical Outcomes for Deep Brain Stimulation

    The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits, and complications.

    Stage

    Not phased

    Ages

    Any age

    Site

    Washington University in St Louis, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT03992625 on ClinicalTrials.gov