Dry Eye Clinical Trials

15 studies are recruiting for dry eye in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Studies now recruiting

1. BL-RX01-TFSTAB-1402

   A study to investigate the ability of the iTrace™, BOSA™, OPD-Scan III, and IDRA to detect tear film stability utilizing Miebo®

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Vance Thompson Vision, Sioux Falls, South Dakota

   Run by

   Vance Thompson Vision

   See if you can join NCT07790211 on ClinicalTrials.gov

2. Long-term Effects of Acoltremon vs. Control in Dry Eye Disease

   This is a prospective, longitudinal, single-center study designed to evaluate the long-term changes in symptoms and tear production in subjects with dry eye disease. The study is randomized and investigator-masked, with subjects assigned to either the TRYPTYR (Acoltremon ophthalmic solution 0.003%)…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Butchertown Clinical Trials, Louisville, Kentucky

   Run by

   The Eye Care Institute

   See if you can join NCT07659626 on ClinicalTrials.gov

3. Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg

   The objective of this study is to evaluate whether twice-daily use of Tyrvaya improves contact lens comfort in contact lens wearers.

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Ocular Clinical Trials, Houston, Texas

   Run by

   Ocular Aesthetics, LLC dba Ocular Clinical Trials

   See if you can join NCT07705893 on ClinicalTrials.gov

4. Autologous Serum Tears With Hyaluronate vs Balanced Salt Solution for Moderate-to-Severe Dry Eye

   This study aims to find out whether adding sodium hyaluronate, a moisturizing ingredient commonly found in artificial tears, makes autologous serum eye drops more effective for treating moderate-to-severe dry eye disease. Each participant will use one version of the drops in one eye and the standar…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Bascom Palmer Eye Institute, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT07413172 on ClinicalTrials.gov

5. Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK

   Collecting data using Kera Sol tear usage during the initial two-week post-operative period after Laser-Assisted In Situ Keratomileusis (LASIK) has on the signs and symptoms of surgical temporary ocular discomfort syndrome (STODS)

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Vance Thompson Vision Clinic, Prof. LLC, Sioux Falls, South Dakota

   Run by

   Vance Thompson Vision

   See if you can join NCT07155070 on ClinicalTrials.gov

6. The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease

   The central hypothesis is that inflammation contributes to dry eye and that rinsing the palpebral conjunctiva, bulbar conjunctiva, and fornices will reduce the inflammatory burden on the ocular surface.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Everett and Hurite Ophthalmic Association, Pittsburgh, Pennsylvania

   Run by

   Rinsada

   See if you can join NCT07618364 on ClinicalTrials.gov

7. Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment

   The purpose of this study is to examine the impact of nasal spray treatment on Meibomian gland function and ocular surface health in symptomatic dry eye patients with mild to moderate Meibomian gland dysfunction (MGD).

   Stage

   Phase 4

   Ages

   18 and older

   Site

   U.C. Berkeley Clinical Research Center, Berkeley, California

   Run by

   University of California, Berkeley

   See if you can join NCT07606625 on ClinicalTrials.gov

8. Comparative Assessment of Lipid Layer Thickness Measurements

   This study compares ocular lipid layer thickness (LLT) measurements obtained from three commonly used clinical diagnostic devices to evaluate their agreement and consistency. It further examines which device's LLT measurements show the strongest correlation with established clinical indicators of d…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   Atwater Eye Care Center, Bloomington, Indiana

   Run by

   Indiana University

   See if you can join NCT07579130 on ClinicalTrials.gov

9. Real-World Assessment of VEVYE® for Short-Term Symptom and Sign Improvement of Dry Eye Disease in a Neuro-Ophthalmology Clinic: A 6-Month Prospective Observational Study

   patients from a Neuro Ophthalmology who have dry eye, some of which have neurotrophic keratitis are being analyzed after treatment with Vevye

   Stage

   Not phased

   Ages

   18 and older

   Site

   Neuro Ophthalmology of TX, Houston, Texas

   Run by

   Neuro-Ophthalmology of Texas

   See if you can join NCT07566975 on ClinicalTrials.gov

10. Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses

    This research study is to see if using Lacrifill is safe, easy to use, and helpful for people who wear contact lenses but can't wear them comfortably for long. Specifically, the study aims to determine whether regular use of Lacrifill over a 2-3 month period can help people wear their contacts long…

    Stage

    Phase 4

    Ages

    22 and older

    Site

    Eye Care Specialists, Kingston, Pennsylvania

    Run by

    Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists

    See if you can join NCT07510620 on ClinicalTrials.gov

11. Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work

    This 1-month, 3-visit study will be conducted at the Southern College of Optometry (Memphis, TN), Kannarr Eye Care, LLC (Pittsburg, KS) and Complete Eye Care of Medina (Minneapolis, MN). Adults ≥18 years of age who have been diagnosed with DED for at least 6 months and who are currently symptomatic…

    Stage

    Phase 4

    Ages

    18 to 75

    Site

    Kannar Eye Care, Pittsburg, Kansas

    Locations

    3 in total

    Run by

    Southern College of Optometry

    See if you can join NCT07266948 on ClinicalTrials.gov

12. An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

    The purpose of this study is to determine the safety and efficacy of VSJ-110 compared to placebo in the treatment of dry eye.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Vanda Investigational Site, Newport Beach, California

    Locations

    5 in total

    Run by

    Vanda Pharmaceuticals

    See if you can join NCT07179055 on ClinicalTrials.gov

13. Low Level Light Therapy & Skin Pigmentation

    The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye/meibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Houston College of Optometry, Houston, Texas

    Run by

    University of Houston

    See if you can join NCT07173530 on ClinicalTrials.gov

14. Quality of Life in Presbyopic Patients Who Are Treated With Qlosi

    The goal of this clinical trial is to determine how Qlosi™ (pilocarpine HCL ophthalmic solution) 0.4%impacts the quality of life of participants with presbyopia by using a battery of validated and investigator-developed instruments * Improvement in presbyopic symptoms as measured with the Near Acti…

    Stage

    Phase 4

    Ages

    45 to 64

    Site

    Complete Eye Care of Medina, Medina, Minnesota

    Locations

    2 in total

    Run by

    Southern College of Optometry

    See if you can join NCT07113210 on ClinicalTrials.gov

15. Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

    Single-site, open label pilot study of 20 autoimmune patients diagnosed with dry eye demonstrating via the proparacaine challenge some peripheral corneal pain component. At least 16 patients will receive and complete 12 weeks of 80 units of Acthar Gel to be injected subcutaneously twice weekly via …

    Stage

    Phase 4

    Ages

    18 to 85

    Site

    Toyos Clinic, Nashville, Tennessee

    Run by

    Toyos Clinic

    See if you can join NCT06964269 on ClinicalTrials.gov