Diabetic Retinopathy Clinical Trials

17 studies are recruiting for diabetic retinopathy in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)

   Researchers are looking for new ways to treat diabetic macular edema (DME). In this trial, researchers want to learn if a trial medicine called MK-8748 can treat DME. An available standard (usual) treatment for DME is aflibercept. However, standard treatments such as aflibercept may not work for ev…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Global Research Management ( Site 0066), Glendale, California

   Locations

   8 in total

   Run by

   Merck Sharp & Dohme LLC

   See if you can join NCT07705555 on ClinicalTrials.gov

2. Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema

   Diabetic Retinopathy (DR) is a common eye condition caused by diabetes, where high blood sugar levels damage the blood vessels in the back part of the eye (called the retina). Over time, this damage can lead to vision problems and even blindness if not treated. This study will assess surabgene lomp…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Retinal Consultants Of Arizona - Phoenix - North /ID# 283407, Phoenix, Arizona

   Locations

   33 in total

   Run by

   AbbVie

   See if you can join NCT07592273 on ClinicalTrials.gov

3. Clinical Applications of Advanced Ophthalmic Imaging

   The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased eyes and normal controls. There are two phases in this study. The firs…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Bascom Palmer Eye Institute, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT03135327 on ClinicalTrials.gov

4. A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

   This study will assess the safety, tolerability, and pharmacokinetics (PK) of intravitreal (IVT) injections of RO7663498 in participants with diabetic retinopathy (DR).

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Global Research Management, Glendale, California

   Locations

   3 in total

   Run by

   Hoffmann-La Roche

   See if you can join NCT07588100 on ClinicalTrials.gov

5. National Eye Institute Biorepository for Retinal Diseases

   Background: - To understand diseases of the retina and the eye, information is needed about people with and without such diseases. Researchers want to study these people and follow them over time. They also want to study body tissues and blood to understand the nature of eye disease. Studying genes…

   Stage

   Not phased

   Ages

   2 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Eye Institute (NEI)

   See if you can join NCT01496625 on ClinicalTrials.gov

6. Biomarker of Diabetic Retinopathy

   Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional. This can lead to an improper supply of oxygen and nutrients to the retinal tissue, or it may trigger the formation of new blood vessels in response to th…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Spring Mill Clinic, Carmel, Indiana

   Locations

   3 in total

   Run by

   Indiana University

   See if you can join NCT05079399 on ClinicalTrials.gov

7. Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease

   This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of d…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Wilmer Eye Institute, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT04505618 on ClinicalTrials.gov

8. Village-Integrated Eye Worker Trial II

   The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment. The leading causes of visual impairment are cataract and refractive error, followed by glaucoma, age-r…

   Stage

   Not phased

   Ages

   60 and older

   Site

   University of California, San Francisco, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT03752840 on ClinicalTrials.gov

9. Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities

   An online survey (n=1,500) and 4 focus groups will be conducted with Latinx patients with diabetes (n=20) to obtain preliminary data regarding whether and how patient and clinician video testimonial interventions (n=6) increase eye health literacy and trust in healthcare.

   Stage

   Not phased

   Ages

   18 and older

   Site

   UW Hospital and Clinics, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06257082 on ClinicalTrials.gov

10. Strategies for Improving Linkage-to-Care After Eye Disease Screening

    The goal of this randomized, parallel-group, controlled trial is to compare methods of improving linkage-to-care for participants in the Village Integrated Eye Worker II (VIEW II) trial who are referred to the eye hospital following eye disease screening. Participants who are referred to the hospit…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of California, San Francisco, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06943599 on ClinicalTrials.gov

11. Sleep, Diabetic Retinopathy and Melatonin

    This study explores the use of melatonin in patients with diabetic retinopathy

    Stage

    Phase 2

    Ages

    40 to 65

    Site

    University of Illinois at Chicago, Chicago, Illinois

    Run by

    University of Illinois at Chicago

    See if you can join NCT04547439 on ClinicalTrials.gov

12. Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium

    The objective of this study is to evaluate the safety and image quality of the investigational dye, MB-102, compared to the control dye (fluorescein sodium) in healthy and diseased eyes using fluorescent angiography for retinal vascular disease diagnosis and monitoring.

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of Michigan Kellogg Eye Center, Ann Arbor, Michigan

    Run by

    MediBeacon

    See if you can join NCT04008121 on ClinicalTrials.gov

13. Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy

    This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular ischemia. iPSCs will be generated from the peripheral blood cells of subjects …

    Stage

    Not phased

    Ages

    21 to 98

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03403699 on ClinicalTrials.gov

14. Intraoperative OCT Guidance of Intraocular Surgery II

    The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other mi…

    Stage

    Not phased

    Ages

    0 and older

    Site

    Duke University Eye Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03713268 on ClinicalTrials.gov

15. Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)

    Results from large clinical trials demonstrate a strong association between lipid abnormalities and progression of the most common microvascular complication, diabetic retinopathy (DR). We found that activation of a master regulator of cholesterol metabolism, the nuclear hormone receptors liver X r…

    Stage

    Not phased

    Ages

    21 to 98

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT03403686 on ClinicalTrials.gov

16. Pivotal Trial of Automated Artificial Intelligence (AI) Based System for Early Diagnosis of Diabetic Retinopathy

    In this pivotal trial, we aim to perform a prospective study to find the efficacy of iPredict-DR, an artificial intelligence (AI) based software tool on early diagnosis of Diabetic Retinopathy (DR) in the primary care and endocrinology clinics. DR is one of the leading causes of blindness in the Un…

    Stage

    Not phased

    Ages

    22 and older

    Site

    iHealthScreen Inc., Richmond Hill, New York

    Run by

    iHealthScreen Inc

    See if you can join NCT07151001 on ClinicalTrials.gov

17. A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01

    The goal of this clinical trial is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of VX-01 as stand-alone treatment for Diabetic Retinopathy of Non-Proliferative Type (NPDR). The primary objective of the study is to evaluate the efficacy of daily oral doses of VX-…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Eye Clinic Albury Wodonga, Albury, New South Wales

    Locations

    26 in total

    Run by

    Vantage Biosciences Ltd

    See if you can join NCT06770933 on ClinicalTrials.gov