Diabetic Foot Clinical Trials

16 studies are recruiting for diabetic foot in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. DFC 004 Biomarkers for Active Diabetic Foot Ulcers

   This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care to drive personalized management decisions, and to better inform clini…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arizona College of Medicine, Tucson, Arizona

   Locations

   9 in total

   Run by

   University of Michigan

   See if you can join NCT06104969 on ClinicalTrials.gov

2. Miro3D Wound Matrix for Treatment of Diabetic Foot Ulcers

   This study is designed to evaluate whether the Miro3D Wound Matrix, when used in addition to standard of care, improves healing outcomes in patients with chronic diabetic foot ulcers. Diabetic foot ulcers are a common and serious complication of diabetes and may be difficult to heal despite appropr…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Advanced Foot Care, Phoenix, Arizona

   Locations

   14 in total

   Run by

   Reprise Biomedical, Inc.

   See if you can join NCT07632001 on ClinicalTrials.gov

3. WIREDUP: Wearable Insoles for Recurrent Diabetic Ulcer Prevention

   The primary aim of this study is to demonstrate the impact of the Orpyx® Sensory Insoles (Orpyx Medical Technologies Inc., Calgary AB, Canada) ("Orpyx" or "the Company") as an adjunct to the standard of care (SOC), as compared to SOC alone, on reducing plantar ulceration incidence in individuals wh…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05950659 on ClinicalTrials.gov

4. Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain

   The purpose of this research is to assess whether the use of a topical cream with an active ingredient can reduce the amount of foot pain experienced in participants who have been diagnosed with Diabetic Peripheral Neuropathy (DPN) with minimal side effects or discomfort from use.

   Stage

   EARLY_Phase 1

   Ages

   25 to 75

   Site

   Carilion Clinic, Roanoke, Virginia

   Run by

   Carilion Clinic

   See if you can join NCT07260656 on ClinicalTrials.gov

5. Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence

   This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function. ii) whether such functionally deficient wound closure, manifested as high TEWL, is associated with greater wound recurren…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arizona, Tucson, Arizona

   Locations

   2 in total

   Run by

   University of Pittsburgh

   See if you can join NCT05172089 on ClinicalTrials.gov

6. Modified Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of Hard-to-Heal DFUs

   The purpose of this study is to evaluate the efficacy of four dehydrated complete human placental membrane, also defined as Cellular, Acellular, Matrix-like Products/skin substitutes, plus SOC versus SOC alone in achieving complete closure of hard-to-heal diabetic foot ulcers over 12 weeks using a …

   Stage

   Not phased

   Ages

   18 and older

   Site

   SerenaGroup Omaha Research Center, Omaha, Nebraska

   Locations

   5 in total

   Run by

   StimLabs

   See if you can join NCT06449638 on ClinicalTrials.gov

7. A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers

   A multicenter, prospective, controlled clinical trial evaluating the efficacy of a single layer placental-based allograft and standard of care in the management of nonhealing diabetic foot ulcers.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Royal Research, Hollywood, Florida

   Run by

   Applied Biologics, LLC

   See if you can join NCT07159282 on ClinicalTrials.gov

8. Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers

   The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania

   Run by

   BioLab Holdings

   See if you can join NCT07089602 on ClinicalTrials.gov

9. A Real-World Registry of Chronic Wounds and Ulcers

   WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers. Data are collected during routine care from over 1,400 clinicians across the USA and Puerto Rico using a highly structured c…

   Stage

   Not phased

   Ages

   Any age

   Site

   US Wound Registry, The Woodlands, Texas

   Run by

   U.S. Wound Registry

   See if you can join NCT02280733 on ClinicalTrials.gov

10. Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers

    People with diabetes often experience foot ulcers, which can harm their ability to move, lower their quality of life, and increase the chances of losing a limb. These diabetic foot ulcers (DFUs) commonly come back (recur) even after they've healed, so it's crucial to stop them from returning to avo…

    Stage

    Not phased

    Ages

    21 and older

    Site

    Keck Hospital of USC, Los Angeles, California

    Locations

    3 in total

    Run by

    University of Southern California

    See if you can join NCT06487780 on ClinicalTrials.gov

11. Adapting Lifestyle Offloading for DFUs

    The goal of this pilot clinical trial is to develop and test a tailored occupational therapist-led lifestyle-focused intervention to aid patients in improving diabetic foot ulcer care. The main questions it aims to answer are to determine the acceptability and feasibility of taking a tailored lifes…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Southern California, Los Angeles, California

    Run by

    University of Southern California

    See if you can join NCT06278935 on ClinicalTrials.gov

12. Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

    Title A Multicenter, Prospective, Randomized Controlled Modified Multi-Platform (Matriarch) Trial Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care versus Standard of Care alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers.

    Stage

    Phase 4

    Ages

    21 and older

    Site

    Serena Group, Monroeville, Pennsylvania

    Run by

    Tiger Biosciences, LLC.

    See if you can join NCT06826339 on ClinicalTrials.gov

13. Dehydrated Human Amnion Membrane and Standard of Care Versus Standard of Care Alone in Nonhealing Diabetic Foot Ulcers

    The purpose of this study is to evaluate the efficacy of dehydrated human amnion membrane (dhAM) and standard of care (SOC) versus SOC alone in the closure of nonhealing diabetic foot ulcers (DFUs).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Performance Foot and Ankle Specialists, Thousand Oaks, California

    Run by

    Axolotl Biologix

    See if you can join NCT06550596 on ClinicalTrials.gov

14. Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs

    The purpose of the study is to evaluate the efficacy of multiple human placental membrane products and Standard of Care (SOC) versus SOC alone in the management of nonhealing diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) over 12 weeks using a modified platform trial design.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Poirot Podiatry, Metairie, Louisiana

    Run by

    C5 Biomedical

    See if you can join NCT06674980 on ClinicalTrials.gov

15. Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care Versus Standard of Care

    A Randomized Controlled Multicenter Clinical Trial, Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care versus Standard of Care alone in the management of Nonhealing Diabetic Foot Ulcers

    Stage

    Not phased

    Ages

    18 and older

    Site

    Detroit Foot and Ankle, Clinton Township, Michigan

    Run by

    Applied Biologics, LLC

    See if you can join NCT06564831 on ClinicalTrials.gov

16. Modified Platform Trial Evaluating PpLHACM and SOC Versus SOC Alone in the Treatment of Nonhealing DFUs

    This study will evaluate two human amnion/chorion membrane (ppLHACM) products and Standard of Care (SOC) versus SOC alone in the closure of nonhealing diabetic foot ulcers (DFUs).

    Stage

    Not phased

    Ages

    18 and older

    Site

    SerenaGroup - Monroeville, Monroeville, Pennsylvania

    Run by

    MiMedx Group, Inc.

    See if you can join NCT06600724 on ClinicalTrials.gov