Depressive Symptoms Clinical Trials

30 studies are recruiting for depressive symptoms in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV

   The goal of this randomized clinical trial is to learn if tai chi/qigong decreases depressive symptoms among older people living with HIV compared to a health education class. The main questions it aims to answer are: Does tai chi/qigong reduce depressive symptoms among older people living with HIV…

   Stage

   Not phased

   Ages

   50 to 75

   Site

   Florida International University, Miami, Florida

   Run by

   Florida International University

   See if you can join NCT06586619 on ClinicalTrials.gov

2. Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

   This open-label pilot study examines whether the hallucinogenic drug, psilocybin, given under supportive conditions, is safe and effective for depression in people with Mild Cognitive Impairment (MCI) or early Alzheimer's Disease (AD). This study will also assess whether psilocybin may improve qual…

   Stage

   EARLY_Phase 1

   Ages

   18 to 85

   Site

   Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT04123314 on ClinicalTrials.gov

3. The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

   The goal of this clinical trial is to see if a mobile phone app can deliver depression treatment to African Americans who are depressed. The main question it aims to answer is if this treatment is effective in reducing symptoms of depression. Participants will attend six 90-minute weekly classes vi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Wisconsin, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06206226 on ClinicalTrials.gov

4. Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients

   Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adherence, quality of life, and outcomes after critical illness. Conventional antidepressants have limited utility for rapidly treating depress…

   Stage

   Phase 2

   Ages

   18 to 99

   Site

   Mayo Clinic, Jacksonville, Florida

   Locations

   2 in total

   Run by

   Hospital Italiano de Buenos Aires

   See if you can join NCT07639359 on ClinicalTrials.gov

5. Natural History of Depression, Bipolar Disorder and Suicide Risk

   Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments. In this study, researchers want to perform tests on people undergoing clinical care for…

   Stage

   Not phased

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Mental Health (NIMH)

   See if you can join NCT06462196 on ClinicalTrials.gov

6. Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

   Digital mental health interventions are a cost-effective and efficient approach to expanding the accessibility and impact of psychological treatments; however, little guidance exists for selecting the most effective program for a given individual. In the proposed study, decision rules will develop …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Center for Anxiety and Related Disorders, Boston, Massachusetts

   Run by

   Boston University Charles River Campus

   See if you can join NCT05567640 on ClinicalTrials.gov

7. Strength and Pain-Coping Through Resilience and Knowledge

   Older adults who are 50 years of age and older with depressive symptoms, pain and difficulty with mobility will participate in the SPARK intervention study that includes 8 nurse visits in participants' homes to help participants with participants' pain and mood.

   Stage

   Not phased

   Ages

   50 and older

   Site

   Johns Hopkins School of Nursing, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07228520 on ClinicalTrials.gov

8. Sleep More, Stress Less: 90-Day Trial of Neuralli Mood

   This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in adults experiencing stress or occasional sleep disruption. Participants ser…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Efforia - Decentralized United States Study, New York, New York

   Run by

   Efforia, Inc

   See if you can join NCT07717385 on ClinicalTrials.gov

9. Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)

   This pilot randomized controlled trial will examine the feasibility, acceptability and preliminary efficacy of an adolescent depression prevention program, Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST), in primary care.

   Stage

   Not phased

   Ages

   13 to 17

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT07020572 on ClinicalTrials.gov

10. Our Voices Matter: Intervention for Depression in Youth

    Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests as policies and practices (e.g., redlining, voter suppression, mass incarceration) that produce hos…

    Stage

    Not phased

    Ages

    15 to 20

    Site

    Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

    Run by

    Ann & Robert H Lurie Children's Hospital of Chicago

    See if you can join NCT07216326 on ClinicalTrials.gov

11. Michigan Men's Diabetes Project III(MenDIII): Mind and Motion

    The Michigan Men's Diabetes Project III: Mind \& Motion is an 7-month pilot randomized clinical trial. The investigators are looking to recruit 80 Black men with type 2 diabetes (T2D) (need to have diagnosis for at least one year) that are over the age of 18. Participants also must be under the car…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Michigan, Ann Arbor, Michigan

    Run by

    University of Michigan

    See if you can join NCT06574035 on ClinicalTrials.gov

12. Cancer Pain Management Using a Web-based Intervention

    This study is funded by the HEAL Initiative (https://heal.nih.gov/). Based on Preliminary Studies (PSs), the research team developed and pilot-tested an evidence-based Web App-based information and coaching/support program for cancer pain management (CAPA) that was culturally tailored to Asian Amer…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06085313 on ClinicalTrials.gov

13. RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

    It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-op…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    UPMC East, Monroeville, Pennsylvania

    Locations

    3 in total

    Run by

    University of Pittsburgh

    See if you can join NCT05658796 on ClinicalTrials.gov

14. My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

    The purpose of this study is to examine the implementation and effectiveness of the psychosocial eHealth intervention, My Wellbeing Guide, on the proposed primary outcome, depressive symptoms, in patients diagnosed with cancer who receive care at Northwestern Medicine and the University of Miami He…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern University, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT05369429 on ClinicalTrials.gov

15. Mobile CBT for Middle Aged and Older Adults

    This study aims to assess a mobile app called MAYA for use in middle-aged and older adults with anxiety or mood disorders. The MAYA app is designed to teach coping skills for anxiety and depression that are drawn from cognitive behavioral therapy. Participants will be asked to use the app for at le…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05754151 on ClinicalTrials.gov

16. IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)

    The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors. Moodivate was developed by our research team to assist with the treatment of depressed mood. Participants will be randomly assigned to either download the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06582784 on ClinicalTrials.gov

17. Caregiver Stress and Sleep Study

    The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health. This study includes a randomized experimental component where therapists will systematically deliver one of two evidence-based talk-therapy treatments. The aim i…

    Stage

    Not phased

    Ages

    55 and older

    Site

    UPMC Western Behavioral Health, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT05219955 on ClinicalTrials.gov

18. Mindfulness Engaged Neurostimulation for Depression (MEND II)

    Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, r…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    UC San Diego Health Psychiatry, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT07512284 on ClinicalTrials.gov

19. rTMS for Military TBI-related Depression

    The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in United States (U.S.) military service members and veterans with a his…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Locations

    3 in total

    Run by

    Henry M. Jackson Foundation for the Advancement of Military Medicine

    See if you can join NCT05426967 on ClinicalTrials.gov

20. Family Spirit Strengths

    This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities. Access to culturally competent and effective behavioral health services is limited in many of these communities. The investigat…

    Stage

    Not phased

    Ages

    14 and older

    Site

    Johns Hopkins Center for Indigenous Health, Chinle, Arizona

    Locations

    3 in total

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT05836090 on ClinicalTrials.gov

21. Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

    The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantl…

    Stage

    Not phased

    Ages

    19 to 65

    Site

    University of South Alabama, Mobile, Alabama

    Run by

    University of South Alabama

    See if you can join NCT06467695 on ClinicalTrials.gov

22. Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)

    This study will enroll 120 women living with ovarian cancer following completion of initial treatment. Our objective is to test an intervention designed to provide support during the survivorship transition for this population, who live with a high degree of morbidity related to the illness and its…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dan L Duncan Comprehensive Cancer Center at the O'Quinn Medical Tower at Baylor St. Luke's Medical Center, Houston, Texas

    Locations

    3 in total

    Run by

    Baylor College of Medicine

    See if you can join NCT05752448 on ClinicalTrials.gov

23. VR-PMR for Post-Burn Symptoms

    The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors. The main questions it aims to…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins Bayview Medical Center, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT07317271 on ClinicalTrials.gov

24. BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women

    The goal of this clinical trial is to evaluate if the combined treatment with EXOMIND (BTL-699-2) and EMSELLA (HPM-6000UF) devices is able to improve depressive symptoms and sexual function in women who are perimenopausal or postmenopausal without an alternative medical cause before enrollment in t…

    Stage

    Not phased

    Ages

    40 and older

    Site

    Luxury Psychiatry Clinic, Winter Garden, Florida

    Locations

    3 in total

    Run by

    BTL Industries Ltd.

    See if you can join NCT07413705 on ClinicalTrials.gov

25. Cannabidiol for Reduction of Brain Neuroinflammation

    This study will investigate whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain (cLBP) with or without mild-to-moderate depression.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT05066308 on ClinicalTrials.gov