Depressive Disorder, Major Clinical Trials in Boston, Massachusetts

5 studies are recruiting for depressive disorder, major in Boston, Massachusetts right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

   The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia sympto…

   Stage

   Phase 3

   Ages

   18 to 74

   Site

   Boston Clinical Trials, Boston, Massachusetts

   Locations

   205 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06559306 on ClinicalTrials.gov

2. A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

   The purpose of this study is to evaluate how well JNJ-54135419 works (efficacy) in addition to comprehensive standard of care (SoC) in rapidly reducing the symptoms of major depressive disorder (MDD, a mental disorder characterized by a persistent feeling of sadness and loss of interest in activiti…

   Stage

   Phase 3

   Ages

   12 to 17

   Site

   Boston Childrens Hospital, Boston, Massachusetts

   Locations

   39 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT07227454 on ClinicalTrials.gov

3. A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

   The main purpose of this study is to assess how well the study drug (JNJ-42847922) works (efficacy) compared with placebo in improving depressive symptoms in participants with major depressive disorder ([MDD], a common mood disorder that causes a lasting feeling of sadness and a loss of interest in…

   Stage

   Phase 3

   Ages

   18 to 74

   Site

   Adams Clinical Boston, Boston, Massachusetts

   Locations

   39 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT07573176 on ClinicalTrials.gov

4. A Study of Brenipatide in Adult Participants With Major Depressive Disorder

   This study evaluates the safety and efficacy of brenipatide when administered with standard of care (SoC) compared to placebo plus SoC in delaying the return of major depressive symptoms. The trial is divided into three periods as follows: a screening period that will last approximately 1 month, a …

   Stage

   Phase 3

   Ages

   18 to 75

   Site

   Adams Clinical Boston, Boston, Massachusetts

   Locations

   179 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07412756 on ClinicalTrials.gov

5. Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

   This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.

   Stage

   Phase 2

   Ages

   25 to 50

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06136546 on ClinicalTrials.gov