Depression - Major Depressive Disorder Clinical Trials

22 studies are recruiting for depression - major depressive disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Lumateperone for Late-Life Depression

   The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment-resistant depression. Lumateperone (Caplyta) is approved by the U.S. Food and Drug Administration to treat Major Depressive Disorder in adu…

   Stage

   Phase 3

   Ages

   60 and older

   Site

   University of Arizona, Tucson, Arizona

   Locations

   2 in total

   Run by

   Eric Lenze

   See if you can join NCT07623135 on ClinicalTrials.gov

2. An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.

   The goal of this prospective, randomized clinical trial is to learn whether pharmacogenomic (PGx)-guided comprehensive medication management delivered by pharmacists in community pharmacies will improve antidepressant treatment outcomes. The primary aim is to determine whether comprehensive medicat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   University of Pittsburgh

   See if you can join NCT07373470 on ClinicalTrials.gov

3. Meditative Neurofeedback for Depression

   The goal of this study is to test a meditative neurofeedback intervention for depressed mood.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of California San Diego, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT06675240 on ClinicalTrials.gov

4. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

   The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more …

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   UAB Psychiatry and Behavioral Neurology, Birmingham, Alabama

   Locations

   69 in total

   Run by

   Cybin IRL Limited

   See if you can join NCT06793397 on ClinicalTrials.gov

5. The Medically Tailored Groceries and Mental Health Study

   This randomized controlled trial will test whether providing medically tailored groceries for 6 months can improve depressive symptoms among adults with depression and food insecurity. The intervention under study is a 6-month, medically tailored grocery program provided by the Boston-based non-pro…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Community Care Cooperative (C3), Worcester, Massachusetts

   Locations

   3 in total

   Run by

   University of Massachusetts, Worcester

   See if you can join NCT07779707 on ClinicalTrials.gov

6. Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression

   The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive virtual reality (VR) headset to engage in behavioral activation (BA) for older adults diagnosed with major depressive disorder (MDD). The secondary aim of this study is to explore the…

   Stage

   Not phased

   Ages

   65 and older

   Site

   Stanford University, Stanford, California

   Run by

   Stanford University

   See if you can join NCT07188623 on ClinicalTrials.gov

7. Psilocybin to Treat Depression in Spinal Cord Injury

   The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg). The main question the study aims to answer is: does psilocybin increase the number a…

   Stage

   Phase 1

   Ages

   22 and older

   Site

   James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York

   Run by

   James J. Peters Veterans Affairs Medical Center

   See if you can join NCT07251491 on ClinicalTrials.gov

8. Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

   Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Duke University School of Medicine, Durham, North Carolina

   Locations

   2 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT07050355 on ClinicalTrials.gov

9. Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains

   Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disorder (MDD). Current treatments are partially effective and the role of SIPs in MDD is vastly unexplored. Preliminary data suggests that SIPs a…

   Stage

   Phase 1

   Ages

   18 to 60

   Site

   Lindner Center of Hope, Mason, Ohio

   Run by

   University of Cincinnati

   See if you can join NCT06795451 on ClinicalTrials.gov

10. Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

    This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07082998 on ClinicalTrials.gov

11. Enhancing Slow Wave Sleep in Depression

    The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression. It will also determine if increased deep sleep improves cognitive performance and mood ratings. Participants will be asked to wear a non-invasive device tha…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT07143838 on ClinicalTrials.gov

12. Mindfulness-based Psilocybin Therapy for PTSD

    The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connec…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    The Ohio State University Medical Center, Columbus, Ohio

    Run by

    Anthony P King

    See if you can join NCT07104916 on ClinicalTrials.gov

13. Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

    The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outco…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06878859 on ClinicalTrials.gov

14. Stratified Pharmacological Approaches for Regulating Circuit-Level Effects

    This research study aims to understand how people with depression respond to the medication pramipexole and to determine whether clinical response differs depending on the function of specific circuits in the brain. The investigators hope to learn which circuits are involved in depression and how t…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT07022405 on ClinicalTrials.gov

15. IMST for Dementia Risk Reduction

    Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine second…

    Stage

    Not phased

    Ages

    60 to 80

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07349706 on ClinicalTrials.gov

16. Nutritional Intervention for College Students With Depression

    The goal of this clinical trial is to assess the feasibility of nutritional interventions in college students with depression. The main outcomes it aims to measure are: * Nutritional content, meal timing, and sleep patterns in college students with depression * Feasibility of nutritional interventi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of California San Diego, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07490782 on ClinicalTrials.gov

17. Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

    Survivors of critical illness are at high risk for mental health issues such as anxiety, depression, and PTSD. This single-site, randomized controlled trial at the Medical University of South Carolina will enroll 150 patients to compare outcomes between a behavioral health Collaborative Care Model …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07372586 on ClinicalTrials.gov

18. Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

    This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors. The intervention includes telehealth-enabled behavioral health assessments and access to the NeuroFlow platform. A subset of parti…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07390786 on ClinicalTrials.gov

19. Open-Label Psilocybin Study in Transdiagnostic Population

    The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT06442423 on ClinicalTrials.gov

20. The Effect of PROSE or Scleral Lenses on Mental Health

    The goal of this prospective clinical trial is to evaluate the effect that prosthetic replacement of the ocular surface ecosystem (PROSE, BostonSight, Needham MA) treatment may have on mental health, particularly affective mood disorders. Correlation between changes in mental health and ocular symp…

    Stage

    Not phased

    Ages

    Any age

    Site

    BostonSight, Needham, Massachusetts

    Run by

    Boston Sight

    See if you can join NCT07195721 on ClinicalTrials.gov

21. Digital Intervention for Physical Activity

    The present study will assess the effects of a four-week digitally delivered intervention on physical activity and depressive symptoms among adults experiencing at least moderate depressive symptoms. The main questions this research aims to answer are: * Does a digitally-delivered intervention incr…

    Stage

    Not phased

    Ages

    19 to 40

    Site

    Kinesiology Building, Auburn, Alabama

    Run by

    Auburn University

    See if you can join NCT07130734 on ClinicalTrials.gov

22. Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression

    The goal of this study is to examine attentional biases for facial displays of emotion as a mechanism of risk in infants of mothers with postpartum major depression, and the potential role of infant arousal in the development of these attentional biases.

    Stage

    Not phased

    Ages

    0 and older

    Site

    Binghamton University, Binghamton, New York

    Run by

    Binghamton University

    See if you can join NCT06835855 on ClinicalTrials.gov