Depression - Major Depressive Disorder Clinical Trials

29 studies are recruiting for depression - major depressive disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

   The purpose of this study is to determine the efficacy, safety and tolerability of CYB003 compared to matching placebo as adjunctive treatment in patients with MDD. For more information about the EMBRACE study, including participating study locations, and to register your interest in learning more …

   Stage

   Phase 3

   Ages

   18 to 85

   Site

   UAB Psychiatry and Behavioral Neurology, Birmingham, Alabama

   Locations

   79 in total

   Run by

   Cybin IRL Limited

   See if you can join NCT06793397 on ClinicalTrials.gov

2. Open-Label Psilocybin Study in Transdiagnostic Population

   The primary objective of this study is to investigate the safety, feasibility, and tolerability of psilocybin treatment in individuals with functional impairment due to psychiatric symptoms. The secondary objective of this study is to determine whether individuals with functional impairments due to…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Connecticut Mental Health Center - Yale School of Medicine, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06442423 on ClinicalTrials.gov

3. Digital Intervention for Physical Activity

   The present study will assess the effects of a four-week digitally delivered intervention on physical activity and depressive symptoms among adults experiencing at least moderate depressive symptoms. The main questions this research aims to answer are: * Does a digitally-delivered intervention incr…

   Stage

   Not phased

   Ages

   19 to 40

   Site

   Kinesiology Building, Auburn, Alabama

   Run by

   Auburn University

   See if you can join NCT07130734 on ClinicalTrials.gov

4. Understanding the Neural Underpinnings of Risk-Taking Behavior in Psychiatric Disease

   The purpose of this study is to understand how the orbitofrontal cortex (OFC), a region at the front of the brain, guides decisions about whether to pursue a possible reward when doing so also carries a risk of loss, and how this process is altered in depression. People with depression are often le…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCSF, San Francisco, California

   Run by

   University of California, San Francisco

   See if you can join NCT07896343 on ClinicalTrials.gov

5. Mindfulness-based Psilocybin Therapy for PTSD

   The goal of this study is to learn how psilocybin delivered with mindfulness-based therapy may help symptoms of posttraumatic stress disorder (PTSD). This is an assessor-blinded, randomized, controlled study in participants with PTSD. The study will investigate the changes in brain activity, connec…

   Stage

   Phase 2

   Ages

   21 to 65

   Site

   The Ohio State University Medical Center, Columbus, Ohio

   Run by

   Anthony P King

   See if you can join NCT07104916 on ClinicalTrials.gov

6. Meditative Neurofeedback for Depression

   The goal of this study is to test a meditative neurofeedback intervention for depressed mood.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of California San Diego, La Jolla, California

   Run by

   University of California, San Diego

   See if you can join NCT06675240 on ClinicalTrials.gov

7. Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder

   The purpose of this research study is to investigate a closed-loop transcranial alternating current stimulation (tACS) device to evaluate its ability to reduce symptoms of major depressive disorder

   Stage

   Not phased

   Ages

   22 and older

   Site

   Qortical Clinical Partners, Durham, North Carolina

   Run by

   Pulvinar Neuro, LLC

   See if you can join NCT07282678 on ClinicalTrials.gov

8. Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms

   Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time. Right now, there is no proven treatment that effectively addresses both the depression and these physical symptoms together. This study w…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Depression Clinical and Research Program, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07610928 on ClinicalTrials.gov

9. IMST for Dementia Risk Reduction

   Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine second…

   Stage

   Not phased

   Ages

   60 to 80

   Site

   Florida State University, Tallahassee, Florida

   Run by

   Florida State University

   See if you can join NCT07349706 on ClinicalTrials.gov

10. Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression

    The goal of this study is to examine attentional biases for facial displays of emotion as a mechanism of risk in infants of mothers with postpartum major depression, and the potential role of infant arousal in the development of these attentional biases.

    Stage

    Not phased

    Ages

    0 and older

    Site

    Binghamton University, Binghamton, New York

    Run by

    Binghamton University

    See if you can join NCT06835855 on ClinicalTrials.gov

11. tDCS for Late-Life Depression

    The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD). The study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered …

    Stage

    Phase 1

    Ages

    60 and older

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    Andre Russowsky Brunoni

    See if you can join NCT07657234 on ClinicalTrials.gov

12. Mobile Cognitive Behavioral Therapy in Early Stroke Recovery

    This study aims to pilot "Maya," a mobile cognitive behavioral therapy app, for use in adults with stroke experiencing depression and/or anxiety. This study will assess the acceptability, feasibility, and preliminary efficacy of Maya within the acute rehabilitation period.

    Stage

    Not phased

    Ages

    18 to 79

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07639606 on ClinicalTrials.gov

13. Biomarker-Guided Antidepressant Selection

    Depression is one of the leading causes of disability worldwide. Common treatments like antidepressant medications and talk therapy work well for some people, but many others do not improve, even after trying multiple treatments. This study will investigate two alternative treatment options for peo…

    Stage

    Phase 4

    Ages

    18 to 70

    Site

    Weill Cornell Medicine, New York, New York

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT07680140 on ClinicalTrials.gov

14. The Medically Tailored Groceries and Mental Health Study

    This randomized controlled trial will test whether providing medically tailored groceries for 6 months can improve depressive symptoms among adults with depression and food insecurity. The intervention under study is a 6-month, medically tailored grocery program provided by the Boston-based non-pro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Community Care Cooperative (C3), Worcester, Massachusetts

    Locations

    3 in total

    Run by

    University of Massachusetts, Worcester

    See if you can join NCT07779707 on ClinicalTrials.gov

15. Singula Phase 0.1 Primary Care Pilot

    This prospective, single-arm, observational pilot study evaluates a clinical decision support system developed by Singula Health for use in primary care. Adult patients complete a self-report assessment before a routine primary care visit. The system uses the responses to generate a clinician-facin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    WestDocs Concierge, Mount Kisco, New York

    Locations

    2 in total

    Run by

    Singula Health, Inc.

    See if you can join NCT07834684 on ClinicalTrials.gov

16. Lumateperone for Late-Life Depression

    The purpose of this research study is to examine how well a medication called lumateperone (Caplyta) works to relieve depression in older adults with treatment-resistant depression. Lumateperone (Caplyta) is approved by the U.S. Food and Drug Administration to treat Major Depressive Disorder in adu…

    Stage

    Phase 3

    Ages

    60 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    2 in total

    Run by

    Eric Lenze

    See if you can join NCT07623135 on ClinicalTrials.gov

17. An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.

    The goal of this prospective, randomized clinical trial is to learn whether pharmacogenomic (PGx)-guided comprehensive medication management delivered by pharmacists in community pharmacies will improve antidepressant treatment outcomes. The primary aim is to determine whether comprehensive medicat…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT07373470 on ClinicalTrials.gov

18. Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression

    The primary aims of this study are to assess the feasibility, acceptability, and tolerability of using an immersive virtual reality (VR) headset to engage in behavioral activation (BA) for older adults diagnosed with major depressive disorder (MDD). The secondary aim of this study is to explore the…

    Stage

    Not phased

    Ages

    65 and older

    Site

    Stanford University, Stanford, California

    Run by

    Stanford University

    See if you can join NCT07188623 on ClinicalTrials.gov

19. Psilocybin to Treat Depression in Spinal Cord Injury

    The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg). The main question the study aims to answer is: does psilocybin increase the number a…

    Stage

    Phase 1

    Ages

    22 and older

    Site

    James J. Peters Department of Veterans Affairs Medical Center, The Bronx, New York

    Run by

    James J. Peters Veterans Affairs Medical Center

    See if you can join NCT07251491 on ClinicalTrials.gov

20. Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

    Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose …

    Stage

    Not phased

    Ages

    21 and older

    Site

    Duke University School of Medicine, Durham, North Carolina

    Locations

    2 in total

    Run by

    Medical University of South Carolina

    See if you can join NCT07050355 on ClinicalTrials.gov

21. Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains

    Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disorder (MDD). Current treatments are partially effective and the role of SIPs in MDD is vastly unexplored. Preliminary data suggests that SIPs a…

    Stage

    Phase 1

    Ages

    18 to 60

    Site

    Lindner Center of Hope, Mason, Ohio

    Run by

    University of Cincinnati

    See if you can join NCT06795451 on ClinicalTrials.gov

22. Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

    This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07082998 on ClinicalTrials.gov

23. Enhancing Slow Wave Sleep in Depression

    The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression. It will also determine if increased deep sleep improves cognitive performance and mood ratings. Participants will be asked to wear a non-invasive device tha…

    Stage

    Not phased

    Ages

    40 to 80

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT07143838 on ClinicalTrials.gov

24. Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

    The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outco…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06878859 on ClinicalTrials.gov

25. Stratified Pharmacological Approaches for Regulating Circuit-Level Effects

    This research study aims to understand how people with depression respond to the medication pramipexole and to determine whether clinical response differs depending on the function of specific circuits in the brain. The investigators hope to learn which circuits are involved in depression and how t…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Stanford University, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT07022405 on ClinicalTrials.gov