Depression, Anxiety Clinical Trials

23 studies are recruiting for depression, anxiety in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

   To learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy on depression and/or anxiety in participants who are being treated for advanced cancer.

   Stage

   Phase 2

   Ages

   25 and older

   Site

   MD Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT06200155 on ClinicalTrials.gov

2. The COMParing App Support Strategies Study

   The overall purpose of this study is to help determine how best to incorporate small amounts of human and digital support into a meditation app. The meditation app used is the Healthy Minds Program (HMP) which provides training in four pillars of well-being (Awareness, Connection, Insight, Purpose)…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Center for Healthy Minds, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07278466 on ClinicalTrials.gov

3. Modulating Exercise Dosage to Improve Concussion Recovery

   Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whethe…

   Stage

   Phase 1

   Ages

   13 to 18

   Site

   University of Colorado Denver, Aurora, Colorado

   Locations

   3 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT05434130 on ClinicalTrials.gov

4. Mental Health in Primary Care

   The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary car…

   Stage

   Not phased

   Ages

   12 to 16

   Site

   Mailman for Child Devlopment, Miami, Florida

   Locations

   17 in total

   Run by

   University of Miami

   See if you can join NCT05426057 on ClinicalTrials.gov

5. Search for Novel Transcranial Magnetic Stimulation (TMS) Targets for Mental Illness

   Participants will receive Transcranial Magnetic Stimulation (TMS) at a random location in the left prefrontal cortex, excluding sites that are potentially unsafe. Extensive behavioral testing will be conducted to determine which behaviors are modulated by stimulating which circuits.

   Stage

   Phase 2

   Ages

   18 to 65

   Site

   Acacia Clinics, Sunnyvale, California

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06376734 on ClinicalTrials.gov

6. Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

   This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress, and anxiety in patients with first episode bipolar I disorder.

   Stage

   Phase 2

   Ages

   18 to 50

   Site

   McLean Hospital, Belmont, Massachusetts

   Run by

   Mclean Hospital

   See if you can join NCT05837104 on ClinicalTrials.gov

7. Multidimensional Sleep Health Intervention to Optimize Concussion Recovery

   Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep insufficiency. Given the sparse guidance that exists for clinicians to provide evi…

   Stage

   Not phased

   Ages

   10 to 19

   Site

   University of Colorado Denver, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07082218 on ClinicalTrials.gov

8. Training in Evidence-based Treatments in Psycho-Oncology

   The goal of this research study is to train psychotherapists to administer individualized evidence-based psychotherapies in a cancer care setting to patients and caregivers with elevated levels of distress. The intervention will mirror clinical care in psycho-oncology in which the therapist, collab…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital Cancer Center, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT05674357 on ClinicalTrials.gov

9. Test of Target Engagement of Ambiguity Aversion

   The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

   Stage

   Not phased

   Ages

   25 to 60

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT06962527 on ClinicalTrials.gov

10. Harlem Strong Mental Health Coalition

    Addressing health disparities, especially in the face of coronavirus pandemic, requires an integrated multi-sector equity-focused, community-based approach. This study will examine the impact of Harlem Strong Community Mental Health Collaborative, a community-wide multi-sectoral coalition in which …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    CUNY Graduate School of Public Health and Health Policy, New York, New York

    Locations

    2 in total

    Run by

    City University of New York, School of Public Health

    See if you can join NCT05833555 on ClinicalTrials.gov

11. Prevention of Psychological Health Problems Via Integrated Operational Support

    Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit service members. Giving technicians training in, and access to, evidence-based interventions (EBI) …

    Stage

    Not phased

    Ages

    18 and older

    Site

    New York University, New York, New York

    Run by

    New York University

    See if you can join NCT06981598 on ClinicalTrials.gov

12. Youth Emotional and Behavioral Treatment Study

    This study aims to characterize key mechanisms underlying the development, maintenance, and treatment of severe irritability in a clinically heterogeneous sample of school-aged youth.

    Stage

    Not phased

    Ages

    4 to 17

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07296939 on ClinicalTrials.gov

13. Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

    The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study …

    Stage

    Phase 1

    Ages

    14 to 21

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT05685368 on ClinicalTrials.gov

14. Examining the Efficacy of a Digital Therapeutic to Prevent Suicidal Behaviors

    The primary aim of the project is to test the efficacy of BCBT delivered via a digital platform (i.e., smartphone) to Servicemembers with recent suicidal ideation and/or suicide attempts presenting to primary care clinics. Given existing challenges of scaling empirically-supported treatments/interv…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Fort Carson, Colorado Springs, Colorado

    Run by

    University of Memphis

    See if you can join NCT06318962 on ClinicalTrials.gov

15. Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

    The purpose of this research study is to refine customized in-app notifications in order to optimize users' experience with a mobile app called Wysa for Chronic Pain. This app is designed to support people who have chronic pain and who also experience symptoms of depression and/or anxiety. This ver…

    Stage

    Not phased

    Ages

    45 and older

    Site

    Washington University in St. Louis School of Medicine, St Louis, Missouri

    Run by

    Washington University School of Medicine

    See if you can join NCT06978166 on ClinicalTrials.gov

16. Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

    The goal of this research study is to adapt an ACT-self-help workbook to the prison setting and determine the feasibility acceptability, and effectiveness of this workbook. Participants can expect to be in the study for 13 weeks.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06162624 on ClinicalTrials.gov

17. Building Connections

    Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population heavily represented in Community Clinics and Health Centers. The progr…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Disparities Research Unit, Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT07091032 on ClinicalTrials.gov

18. Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression

    This mechanistic study uses an anti anxiety drug and brain imaging to study the threat processing system and associated brain circuits in people with depression, anxiety disorders and comorbid depression and anxiety disorders. In a double blind, placebo controlled crossover design, up to 65 individ…

    Stage

    Phase 4

    Ages

    18 to 65

    Site

    Laureate Institute for Brain Research, Tulsa, Oklahoma

    Run by

    Laureate Institute for Brain Research, Inc.

    See if you can join NCT06004115 on ClinicalTrials.gov

19. SUpport From PEeRs to Expand Access Study - Community

    Investigators will evaluate the implementation of an evidence-based, Spanish-language, digital, cognitive-behavioral therapy (dCBT) intervention (SilverCloud) in the Mission community for Latino patients with depression and/or anxiety. 213 participants will be enrolled in a one-armed trial comparin…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Zuckerberg San Francisco General, San Francisco, California

    Run by

    University of California, Berkeley

    See if you can join NCT07186816 on ClinicalTrials.gov

20. Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss

    The goal of this study is to develop and pilot test a therapeutic strategy combining cognitive behavioral therapy (CBT) with mindfulness practices tailored for individuals adjusting to vision loss. The study will begin with focus groups to inform the design of the intervention. Participants will co…

    Stage

    Not phased

    Ages

    18 and older

    Site

    The Chicago Lighthouse, Chicago, Illinois

    Run by

    The Chicago Lighthouse

    See if you can join NCT07073521 on ClinicalTrials.gov

21. Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

    Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, welln…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia

    Run by

    West Virginia School of Osteopathic Medicine

    See if you can join NCT06049420 on ClinicalTrials.gov

22. Promoting Active Therapy: Path to Wellness

    This project will examine changes in depression and anxiety following a 10-week intervention promoting nature-based physical activity in mental health settings. We will recruit ten licensed therapists whose caseload includes adults with depression and anxiety. Following a training by our team, each…

    Stage

    Phase 2

    Ages

    18 to 65

    Site

    Kansas State University, Manhattan, Kansas

    Run by

    Kansas State University

    See if you can join NCT06858189 on ClinicalTrials.gov

23. Creative Arts Program to Reduce Burnout in Healthcare Professionals

    This study plans to learn if creative arts programs that include visual, musical, written, or physical expression can reduce symptoms of burnout syndrome, Post Traumatic Stress Disorder (PTSD), depression, and anxiety in critical care healthcare professionals. This study also explores if creative a…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Colorado - Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT04276922 on ClinicalTrials.gov