Delirium Clinical Trials

21 studies are recruiting for delirium in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

   This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.

   Stage

   Phase 3

   Ages

   60 and older

   Site

   University of California San Francisco, San Francisco, California

   Locations

   14 in total

   Run by

   Massachusetts General Hospital

   See if you can join NCT06192615 on ClinicalTrials.gov

2. Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

   The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older patients during hospital admission. The main objectives of the trial are t…

   Stage

   Not phased

   Ages

   70 and older

   Site

   Saddleback Medical Center, Orange, California

   Locations

   7 in total

   Run by

   University of Michigan

   See if you can join NCT05929703 on ClinicalTrials.gov

3. Pervasive Sensing and AI in Intelligent ICU

   Important information related to the visual assessment of patients, such as facial expressions, head and extremity movements, posture, and mobility are captured sporadically by overburdened nurses, or are not captured at all. Consequently, these important visual cues, although associated with criti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Florida Health Shands Hospital, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05127265 on ClinicalTrials.gov

4. VR-Based Cognitive Stimulation Games for Delirium Prevention

   This trial aims to evaluate the feasibility, safety, and acceptability of a virtual reality (VR)-based cognitive stimulation game to reduce postoperative delirium among older surgical patients at high risk due to pre-existing cognitive impairment.

   Stage

   Not phased

   Ages

   Up to 65

   Site

   Houston Methodist Hospital, Houston, Texas

   Locations

   2 in total

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT07641153 on ClinicalTrials.gov

5. CTSN Embolic Protection Trial

   This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.

   Stage

   Not phased

   Ages

   60 and older

   Site

   CHI St. Vincent Heart Institute, North Little Rock, Arkansas

   Locations

   28 in total

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06027788 on ClinicalTrials.gov

6. Neurosteer Bedside Monitoring System

   The purpose of this study is to evaluate the clinical utility of Neurosteer's brain monitoring platform for monitoring delirium, sedation, and agitation in intubated and sedated ICU patients. The research team will be conducting a single-site study. The research team will enroll 100 patients admitt…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Mount Sinai Hospital, New York, New York

   Run by

   Icahn School of Medicine at Mount Sinai

   See if you can join NCT06718764 on ClinicalTrials.gov

7. Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery

   The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.

   Stage

   Phase 3

   Ages

   60 and older

   Site

   Washington University School of Medicine/Barnes-Jewish Hospital, St Louis, Missouri

   Run by

   Washington University School of Medicine

   See if you can join NCT06969287 on ClinicalTrials.gov

8. TaVNS for Delirium

   The goal of this clinical trial is to test whether a non-invasive device called transauricular vagus nerve stimulation (taVNS) is safe, practical, and potentially helpful for patients in the hospital who develop delirium. Delirium is a state of confusion that often happens to people in the hospital…

   Stage

   Not phased

   Ages

   22 and older

   Site

   Stony Brook University Hospital, Stony Brook, New York

   Run by

   Stony Brook University

   See if you can join NCT07258082 on ClinicalTrials.gov

9. Automating Delirium Severity in the ICU

   The goal of this observational study is to develop a passive digital marker (PDM) for delirium severity and examine its performance in comparison to validated delirium severity tools in ICU patients >50 years of age. The main questions it aims to answer are: * Is the trained convolutional neural ne…

   Stage

   Not phased

   Ages

   50 and older

   Site

   Mayo Clinic, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT06172491 on ClinicalTrials.gov

10. Delirium in Neurodegenerative Disease Patients: A Music Therapy Intervention for Hospital Care

    In this pilot study a new kind of music therapy will be created and tested to help prevent confusion, called delirium, that can happen in the hospital. This can affect people with brain diseases like Alzheimer's disease and Parkinson's disease. Each of the anticipated 30 participants will have up t…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Boston Medical Center, Boston, Massachusetts

    Run by

    Boston Medical Center

    See if you can join NCT07137949 on ClinicalTrials.gov

11. Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

    This initial study is a feasibility study for implementing thoracolumbar interfascial plane, or TLIP, blocks in older adults undergoing spinal fusion. TLIP blocks are done by using anesthesia. In this case, it will be done to either side of the back where surgery will be performed. This has been sh…

    Stage

    EARLY_Phase 1

    Ages

    65 and older

    Site

    University of Iowa, Iowa City, Iowa

    Run by

    University of Iowa

    See if you can join NCT05461092 on ClinicalTrials.gov

12. Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation

    The goal of this step-wedge trial is to test the implementation of daily nurse screening for delirium in routine care and its impact on outcomes and complications in hospitalized older adults admitted to 6 general medicine/surgery units at 3 hospitals in Pennsylvania and Massachusetts. The main que…

    Stage

    Not phased

    Ages

    70 and older

    Site

    Beth Israel Deaconness Medical Center, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Penn State University

    See if you can join NCT05915377 on ClinicalTrials.gov

13. Behavioral Economic & Staffing Strategies in the ICU

    The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically e…

    Stage

    Not phased

    Ages

    19 and older

    Site

    University of Iowa Hospitals and Clinics, Iowa City, Iowa

    Locations

    3 in total

    Run by

    University of Nebraska

    See if you can join NCT06184945 on ClinicalTrials.gov

14. Interventions for Postoperative Delirium: Biomarker-3

    The IPOD-B3 study aims to characterize the relationship between premorbid brain activity and postoperative delirium in patients undergoing major surgery. This is a expansion of the NeuroVISION Bolt-On study, NCT01980511.

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Wisconsin-Madison, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT03124303 on ClinicalTrials.gov

15. Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy

    To examine the effects of haloperidol, chlorpromazine, valproic acid and placebo, in conjunction with standardized non-pharmacologic interventions, in the first line treatment of agitated delirium in hospitalized patients with cancer. This double-blind, randomized clinical trial aims to provide evi…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    MD Anderson Cancer Center, Houston, Texas

    Run by

    M.D. Anderson Cancer Center

    See if you can join NCT05431595 on ClinicalTrials.gov

16. VoiceLove Digital Therapy for Delirium in the ICU

    The study is a single-center, single-arm, prospective trial to evaluate the feasibility, safety, and acceptability of VoiceLOVE digital therapy for the management of delirium in surgical ICU patients. 15 participants will be enrolled. The study expects that 70% of participants will complete 20 -25 …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Houston Methodist Hospital, Houston, Texas

    Run by

    The Methodist Hospital Research Institute

    See if you can join NCT07218484 on ClinicalTrials.gov

17. Ceribell Delirium Data Collection Study

    This study is designed as a prospective, non-randomized, observational clinical study. The study will collect clinical and rrEEG (Ceribell EEG) data when monitoring subjects for delirium subtypes. EEG and clinical data will be collected for the development of future software algorithms to assess th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Locations

    7 in total

    Run by

    Ceribell Inc.

    See if you can join NCT04962815 on ClinicalTrials.gov

18. A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

    Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which con…

    Stage

    Not phased

    Ages

    60 and older

    Site

    University of Washington, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06411561 on ClinicalTrials.gov

19. Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department

    Delirium is highly prevalent and very bad for patients with dementia. Delirium is a dangerous medical condition that occurs in 6-38% of older Emergency Department patients and 70% of ICU patients. A person who develops delirium in the ED or hospital has a 12 times higher odds of being newly diagnos…

    Stage

    Not phased

    Ages

    65 and older

    Site

    The Ohio State University Wexner Medical Center, Columbus, Ohio

    Run by

    Ohio State University

    See if you can join NCT06326424 on ClinicalTrials.gov

20. Modifying the Inpatient Environment to Reduce Delirium in Older Adults

    The overall goal is to reduce the incidence and burden of delirium, as measured by the delirium burden index (DBI) among hospitalized older adults (≥70 years), by modifying the inpatient environment to decrease its sleep antagonism. The investigators propose to implement a multi-modal sleep hygiene…

    Stage

    Not phased

    Ages

    70 and older

    Site

    Houston Methodist Baytown Hospital, Baytown, Texas

    Locations

    5 in total

    Run by

    Farhaan S. Vahidy

    See if you can join NCT06736951 on ClinicalTrials.gov

21. Simultaneous Recumbent Cycling and Cognitive Training

    Intensive care units (ICU) provide life-saving care for nearly five million people annually. Up to 80% of patients receiving care in an ICU experience at least one episode of delirium. Delirium, an acute episodic display of confused thinking and unawareness, predicts impaired cognition and accelera…

    Stage

    Not phased

    Ages

    45 to 64

    Site

    St. Luke's Hospital of Kansas City, Kansas City, Missouri

    Run by

    University of Missouri, Kansas City

    See if you can join NCT04556227 on ClinicalTrials.gov