Degenerative Disc Disease Clinical Trials

19 studies are recruiting for degenerative disc disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Eugene, Oregon 3 Hartford, Connecticut 3 Miami, Florida 3 Nashville, Tennessee 3

Studies now recruiting

  1. Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

    VIA Disc NP is a non-surgical intervention intended to supplement nucleus pulposus tissue in degenerated intervertebral discs. This is a randomized, sham-controlled, multi-center, double-blind clinical trial with an open label roll-in period of one participant per site in which participants with lu…

    Stage
    Not phased
    Ages
    22 to 85
    Site
    Interventional Pain Management Napa Valley Orthopedic Medical Group, Napa, California
    Locations
    19 in total
    Run by
    VIVEX Biologics, Inc.

    See if you can join NCT06778447 on ClinicalTrials.gov

  2. A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

    This is a Phase III, randomized, double-blinded, Sham-controlled, multi-center study in subjects with single-level, symptomatic lumbar (L3- S1) intervertebral disc degeneration. The study will have a 52-week primary period followed by 52 week Follow-up Period (total of 104 weeks). The study protoco…

    Stage
    Phase 3
    Ages
    18 to 75
    Site
    Alabama Clinical Therapeutics, Birmingham, Alabama
    Locations
    28 in total
    Run by
    DiscGenics, Inc.

    See if you can join NCT07254806 on ClinicalTrials.gov

  3. ACDF Using Structural Allograft vs. Tritanium C

    This is an observational, descriptive, prospective and retrospective data collection study. The purpose of this study is to observe radiographic outcomes of patients who will undergo anterior cervical discectomy and fusion (ACDF) utilizing Tritanium C (Stryker Spine). The rate of fusion success and…

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Allegheny Health Network, Pittsburgh, Pennsylvania
    Run by
    Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

    See if you can join NCT04388332 on ClinicalTrials.gov

  4. LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)

    The objective of this study is to evaluate the safety and effectiveness of LDGraft (investigational device) compared to 100% human tissue product allograft bone (control) when applied in an ALIF procedure in the treatment of patients with lumbar degenerative disc disease (DDD).

    Stage
    Phase 1
    Ages
    22 to 80
    Site
    Orthopaedics NorthEast, Fort Wayne, Indiana
    Locations
    4 in total
    Run by
    Locate Bio Pty Ltd

    See if you can join NCT06462729 on ClinicalTrials.gov

  5. Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease

    Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients with Lumbar Degenerative Disc Disease : A Pivotal, Randomized, Prospective, Multi-Center Study

    Stage
    Phase 3
    Ages
    21 to 80
    Site
    University of Arkansas for Medical Sciences, Little Rock, Arkansas
    Locations
    10 in total
    Run by
    CGBio Inc.

    See if you can join NCT07017634 on ClinicalTrials.gov

  6. Biologic Injection For Adults With Lumbar Disc Herniation

    The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation. The main questions it aims to answer are: * Does the BMAC injection lead to…

    Stage
    Not phased
    Ages
    18 and older
    Site
    NewYork-Presbyterian/Weill Cornell Medical Center, Manhattan, New York
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT07386548 on ClinicalTrials.gov

  7. Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

    The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury. The main question it aims to answer is whether EC5026 is safe and well toler…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    AU Medical Center, Augusta, Georgia
    Run by
    EicOsis Human Health Inc.

    See if you can join NCT06438471 on ClinicalTrials.gov

  8. MagnetOs Flex Matrix Compared to Trinity Elite Mixed With Local Autograft in Patients Undergoing up to Four-level Instrumented Posterolateral Fusion

    This is a phase IV post-marketing study for MagnetOs Flex Matrix. MagnetOs Flex Matrix is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease and undergoing spinal fusion surgery. In this study, MagnetOs Flex Matrix w…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hartford Hospital, Hartford, Connecticut
    Locations
    8 in total
    Run by
    Kuros Biosurgery AG

    See if you can join NCT05037968 on ClinicalTrials.gov

  9. Clinical Outcome Measure at Stryker Spine

    This is a multicenter, prospective, retrospective, Post Market Clinical Follow-up (PMCF) study in subjects who have undergone or will undergo surgery utilizing one or more Stryker devices according to Stryker cleared Instructions for Use (IFU).

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic Florida, Jacksonville, Florida
    Locations
    7 in total
    Run by
    VB Spine, LLC

    See if you can join NCT06226272 on ClinicalTrials.gov

  10. OssDsign® Spine Registry Study ("Propel")

    The purpose of this multi-center, prospective, observational registry is to gather information on the clinical outcomes and real-world use of commercially available bone graft substitutes manufactured by OssDsign® AB, in patients who require spine fusion.

    Stage
    Not phased
    Ages
    21 and older
    Site
    Community Health Partners Neuroscience, Fresno, California
    Locations
    15 in total
    Run by
    OssDsign

    See if you can join NCT05329129 on ClinicalTrials.gov

  11. Brain Mechanisms Supporting Cannabis-induced Pain Relief

    Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in…

    Stage
    EARLY_Phase 1
    Ages
    21 to 65
    Site
    Center for Functional MRI - W.M.Keck Building, La Jolla, California
    Run by
    University of California, San Diego

    See if you can join NCT04982965 on ClinicalTrials.gov

  12. Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

    This is a phase IV post-marketing study for MagnetOs Easypack Putty. MagnetOs Easypack Putty is a synthetic bone graft extender product that is routinely used by surgeons as a treatment for patients with degenerative disc disease or spinal trauma undergoing spinal fusion surgery. In this study, Mag…

    Stage
    Not phased
    Ages
    18 and older
    Site
    The Regents of the University of California- Irvine Campus, Irvine, California
    Locations
    6 in total
    Run by
    Kuros Biosurgery AG

    See if you can join NCT04679844 on ClinicalTrials.gov

  13. Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

    Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical …

    Stage
    Phase 4
    Ages
    18 to 80
    Site
    Rush University Medical Center, Chicago, Illinois
    Run by
    John O'Toole

    See if you can join NCT05029726 on ClinicalTrials.gov

  14. Comparison of Artificial Disc Implants in Cervical Disc Arthroplasty

    This study will comprehensively evaluate the outcomes and endpoints of these two different FDA-approved artificial disc implants used to treat cervical spondylotic myelopathy and/or radiculopathy today: Biomet Zimmer Mobi-C and Nuvasive Simplify. Both implants are structurally different with the Nu…

    Stage
    Not phased
    Ages
    18 to 60
    Site
    UCLA, Los Angeles, California
    Run by
    University of California, Los Angeles

    See if you can join NCT05701059 on ClinicalTrials.gov

  15. Conduit Cages and Fibergraft BG Putty

    The Conduit cages are intended to restore the intervertebral height and to facilitate the intervertebral body fusion in the cervical and lumbar spine in skeletally mature patients with degenerative disc disease and instabilities at one or more levels of the spine. The Fibergraft Bioactive Glass (BG…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Run by
    Nitin Agarwal

    See if you can join NCT06704919 on ClinicalTrials.gov

  16. OssiMend BA in Posterolateral Instrumented Lumbar Fusion

    The primary objective of this study is to measure the success rate of lumbar fusion in subjects at 12 months when instrumented lumbar arthrodesis is performed using OssiMend Bioactive Moldable as the bone grafting material

    Stage
    Not phased
    Ages
    18 and older
    Site
    Hartford Hospital, Hartford, Connecticut
    Locations
    4 in total
    Run by
    Collagen Matrix

    See if you can join NCT04775537 on ClinicalTrials.gov

  17. Trial for Treating Painful Degenerative Disc Disease

    To evaluate and compare two platelet-based treatments of the functional spinal unit spaced 4 weeks apart to sham procedures for the treatment of degenerative disc disease.

    Stage
    Not phased
    Ages
    25 to 65
    Site
    Centeno-Schultz Clinic, Broomfield, Colorado
    Locations
    2 in total
    Run by
    Regenexx, LLC

    See if you can join NCT05287867 on ClinicalTrials.gov

  18. Evaluation of Safety and Effectiveness of Primary Hybrid Construct of Mobi-C and ACDF in the Treatment of Two-level Symptomatic Degenerative Disc Disease in the Cervical Spine.

    The study is a prospective, multi-center cohort study of patients with two-level DDD implanted with CDA adjacent to ACDF (hybrid construct). The overall success of the hybrid procedure will be compared to 2-level ACDF historical controls from the Mobi-C IDE trial. 97 patients will receive the hybri…

    Stage
    Not phased
    Ages
    22 to 69
    Site
    University of California-Davis, Sacramento, California
    Locations
    2 in total
    Run by
    Highridge Medical

    See if you can join NCT06485206 on ClinicalTrials.gov

  19. Personalized Spine Study Group (PSSG) Registry

    The primary objective of the study is a data collection initiative. The study will collect clinical and radiographic outcomes of patients implanted with patient specific rods. The secondary objective is to collect clinical and radiographic outcomes of patients with hardware as a control cohort to t…

    Stage
    Not phased
    Ages
    10 to 85
    Site
    Dr. Christopher Kleck, MD, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT04601363 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.