Cystic Fibrosis (CF) Clinical Trials

17 studies are recruiting for cystic fibrosis (cf) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Phase 2 Study to Assess the Safety and Efficacy of ANG003

   In this study, ANG003, a pancreatic enzyme replacement therapy (PERT; commonly called "enzymes"), is being investigated as a potential treatment for exocrine pancreatic insufficiency (EPI). People with EPI due to Cystic Fibrosis (CF) may be eligible to participate in this study. The primary objecti…

   Stage

   Phase 2

   Ages

   12 and older

   Site

   Long Beach Memorial Medical Center, Long Beach, California

   Locations

   26 in total

   Run by

   Anagram Therapeutics, Inc.

   See if you can join NCT07450547 on ClinicalTrials.gov

2. Bacteriophages for Adults With Cystic Fibrosis and Chronic Achromobacter Lung Infection

   The goal of this clinical trial is to learn if a new treatment called AchromoPhage is safe and well tolerated in adults with cystic fibrosis (CF) who have long-term lung infections caused by Achromobacter bacteria. AchromoPhage is a mixture of four naturally occurring viruses, called phages, that a…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Locations

   2 in total

   Run by

   Ghady Haidar

   See if you can join NCT07275905 on ClinicalTrials.gov

3. TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

   This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fibrosis (CF).

   Stage

   Not phased

   Ages

   1 to 11

   Site

   Children's Hospital of Orange County, Orange, California

   Locations

   13 in total

   Run by

   State University of New York at Buffalo

   See if you can join NCT07048574 on ClinicalTrials.gov

4. Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet

   There is no study to date that has evaluated the impact or effect of a Mediterranean diet in children with CF. The goal of this study would be to help provide better guidance around questions the investigators, as CF care providers continue to receive from patients and families about how to best pr…

   Stage

   Not phased

   Ages

   3 to 18

   Site

   Dartmouth Health Children's, Manchester, New Hampshire

   Locations

   2 in total

   Run by

   Dartmouth-Hitchcock Medical Center

   See if you can join NCT07223255 on ClinicalTrials.gov

5. Study to Enable New Diagnostics for Pulmonary Microbes in People With CF

   Sputum culture has been the best approach to detect harmful bacteria in the lungs of people with cystic fibrosis (CF). With the widespread use of new CF therapies (like Trikafta and Alyftrak), it is more difficult for people with CF to produce sputum even though they still have harmful bacteria in …

   Stage

   Not phased

   Ages

   16 and older

   Site

   The Minnesota Cystic Fibrosis Center, Minneapolis, Minnesota

   Locations

   9 in total

   Run by

   Chris Goss

   See if you can join NCT07312734 on ClinicalTrials.gov

6. Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease

   In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in reg…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   University of Kansas Medical Center, Kansas City, Kansas

   Run by

   University of Kansas Medical Center

   See if you can join NCT06985225 on ClinicalTrials.gov

7. Personalized Mobile Health Platform to Promote Physical Activity in Adolescents and Young Adults With Cystic Fibrosis

   The goal of this clinical trial is to help adolescents and young adults between the ages of 13-25 with Cystic Fibrosis (CF), medically stable, able to speak and read English, and are not experiencing a CF - related exacerbation, who are already active to remain, or gradually encourage them to incre…

   Stage

   Not phased

   Ages

   13 to 25

   Site

   Nemours Childrens Health, Jacksonville, Florida

   Run by

   Nemours Children's Clinic

   See if you can join NCT06616857 on ClinicalTrials.gov

8. Ensuring Access to Optimal Therapy in CF: The ENACT Study

   This clinical trial is examining the action and effects of several new drugs in the treatment of cystic fibrosis in children. In addition, several genetic factors are examined. The hope is that the ability to determine prior to treatment those individuals who will or will not respond to existing th…

   Stage

   Phase 4

   Ages

   3 and older

   Site

   The University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   3 in total

   Run by

   Arkansas Children's Hospital Research Institute

   See if you can join NCT07148739 on ClinicalTrials.gov

9. Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

   The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research on chronic diseases, nutrition, and metabolism (the process by which a…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Missouri-Columbia, Columbia, Missouri

   Run by

   Bettina Mittendorfer

   See if you can join NCT07083557 on ClinicalTrials.gov

10. Kidney Function in People With Cystic Fibrosis in the Era of HEMT

    The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it becomes permanent. The study will compare these markers in people with…

    Stage

    Not phased

    Ages

    7 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    3 in total

    Run by

    University of Virginia

    See if you can join NCT06595420 on ClinicalTrials.gov

11. ACT With CF Self-Help Toolkit

    Acceptance and Commitment Therapy (ACT) tailored to meet the needs of adults living with cystic fibrosis (ACT with CF) is a newer form of talk therapy that has been shown to reduce anxiety \& depression and improve psychological flexibility, and value-based living. The investigators are now trying …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT07436351 on ClinicalTrials.gov

12. CF Wellness Program

    This study is a pilot randomized control trial (RCT; N=80) comparing the Cystic Fibrosis Wellness Program (CFWP) to usual care (UC) to evaluate (1) Intervention Adherence (completion of the CFWP Coaching Sessions) (2) Study Retention (completion of the Week 15 assessment) and (3) Data Quality (vali…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Locations

    3 in total

    Run by

    Johns Hopkins University

    See if you can join NCT07071324 on ClinicalTrials.gov

13. Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

    This multicenter cross-sectional study will include a diverse population of adolescents and adults with CF. The overall Aim is to describe prevalence of diabetes microvascular complications and macrovascular surrogates in people with established CFRD.

    Stage

    Not phased

    Ages

    12 and older

    Site

    University of Colorado Denver, Aurora, Colorado

    Locations

    18 in total

    Run by

    Jaeb Center for Health Research

    See if you can join NCT06837181 on ClinicalTrials.gov

14. Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

    The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antib…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Indiana University Health, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT06996951 on ClinicalTrials.gov

15. OnTrackCF: Engagement, Feasibility, and Acceptability Study

    This is a multi-site, nonrandomized study using mixed methods approach to evaluate the feasibility, acceptability, and user engagement of OnTrackCF for adults with Cystic Fibrosis (AWCF).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    3 in total

    Run by

    Boston Children's Hospital

    See if you can join NCT07031323 on ClinicalTrials.gov

16. Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

    The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shands at the University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT01851642 on ClinicalTrials.gov

17. Study With Phage for CF Subjects With Pseudomonas Lung Infection

    The goal of this Phase 2b clinical trial is to see if nebulized phage (BX004) can treat chronic Pseudomonas aeruginosa (PsA) lung infection in CF subjects. The primary goal is to see if 8 weeks of twice daily BX004 can reduce the amount of PsA in the sputum compared to placebo (on top of background…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    14 in total

    Run by

    BiomX Ltd

    See if you can join NCT06998043 on ClinicalTrials.gov