COVID-19 Clinical Trials

36 studies are recruiting for covid-19 in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study

   CIRV2 is a Phase IV randomized, open-label, trial of FDA-approved COVID-19 and/or influenza vaccines (no more than minimal risk) with longitudinal follow-up. In 2026 CIRV2 will compare immunogenicity and reactogenicity of the recombinant Novavax COVID-19 vaccine and the mRNA Pfizer-BioNTech COVID-1…

   Stage

   Phase 4

   Ages

   18 to 79

   Site

   Walter Reed National Military Medical Center, Bethesda, Maryland

   Run by

   Henry M. Jackson Foundation for the Advancement of Military Medicine

   See if you can join NCT07287137 on ClinicalTrials.gov

2. A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults

   This phase 1 randomized, open-label, dose-escalation clinical trial evaluates the safety and immunogenicity of OCU500, a ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine, in healthy adults aged 18-64 who previously completed a primary COVID-19 vaccination series and at least one booster. The study e…

   Stage

   Phase 1

   Ages

   18 to 64

   Site

   The Hope Clinic of Emory University, Decatur, Georgia

   Locations

   6 in total

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT07536308 on ClinicalTrials.gov

3. Viral Infections in Healthy and Immunocompromised Hosts

   Background: - Viral infections are an important cause of illness and death in hospitalized patients as well as outpatients. New strains of viruses may appear and infect both healthy people and those with weak immune systems. A better understanding of these new virus strains (such as SARS-CoV-2, the…

   Stage

   Not phased

   Ages

   0 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Allergy and Infectious Diseases (NIAID)

   See if you can join NCT01306084 on ClinicalTrials.gov

4. Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

   The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms. An additional purpose of this study is to demonstrate that PENFS improves functioning in children with post Covid-19 …

   Stage

   Not phased

   Ages

   11 to 18

   Site

   CHOC Children's, Orange, California

   Run by

   Children's Hospital of Orange County

   See if you can join NCT04978571 on ClinicalTrials.gov

5. Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19

   The purpose of this study is to evaluate the safety and immunogenicity of a single dose of Sanofi's Omicron subvariant-based Nuvaxovid in participants ≥ 65 years of age and participants 12 through 64 years of age who have at least one underlying condition that puts them at increased risk for severe…

   Stage

   Phase 4

   Ages

   12 and older

   Site

   Site #: 8400005, Fair Oaks, California

   Locations

   20 in total

   Run by

   Sanofi

   See if you can join NCT07861542 on ClinicalTrials.gov

6. Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)

   Background: Loss of the sense of smell can seriously affect a person's quality of life. The ability to smell can be damaged by many factors, including illnesses, injuries, and exposure to toxic chemicals. The effects can vary, including complete loss of smell, partial loss, and parosomia, which is …

   Stage

   Not phased

   Ages

   18 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Deafness and Other Communication Disorders (NIDCD)

   See if you can join NCT07149428 on ClinicalTrials.gov

7. Determinants of SARS (Severe Acute Respiratory Syndrome)-COV2 (COVID-19) Persistence After Convalescence

   The 2019-2020 COVID-19 pandemic is the largest outbreak in recent history. It is not known how long after someone gets sick with COVID-19 and recovers that they can still infect other people. It is also not known how quickly people make antibodies against the virus, which help clear infection from …

   Stage

   Not phased

   Ages

   7 and older

   Site

   Columbia University Medical Center, New York, New York

   Run by

   Columbia University

   See if you can join NCT04448145 on ClinicalTrials.gov

8. Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

   The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of breathlessness on daily activities, post-COVID-19 symptom burden, and biomar…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   University of Arizona, Tucson, Arizona

   Locations

   17 in total

   Run by

   Wes Ely

   See if you can join NCT06631287 on ClinicalTrials.gov

9. A Study Evaluating MDX2301 in Healthy Adults and Adults at Higher Risk for Severe COVID-19.

   This first-in-human study is designed to evaluate the safety, tolerability, pharmacokinetics, anti-drug antibodies, and neutralizing activity of MDX2301 administered by intravenous (IV), intramuscular (IM), or subcutaneous (SC) routes in healthy adults and adults at higher risk for severe COVID-19.…

   Stage

   Phase 1

   Ages

   18 to 64

   Site

   TrialMed Clinical Research Unit, Las Vegas, Nevada

   Locations

   2 in total

   Run by

   ModeX Therapeutics, An OPKO Health Company

   See if you can join NCT07445971 on ClinicalTrials.gov

10. Dime La VerDAD: Verify, Debunk, and Disseminate

    Dime la Verdad (Tell me the truth) will evaluate the use of storytelling by community health workers as a communication strategy to disseminate reliable health information on social media and encourage informed decision-making in favor of recommended immunizations in communities with high morbidity…

    Stage

    Not phased

    Ages

    18 to 99

    Site

    University of Chicago, Chicago, Illinois

    Locations

    4 in total

    Run by

    University of Chicago

    See if you can join NCT06417762 on ClinicalTrials.gov

11. A Phase 1/2A, Randomized Study of a T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses

    The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to improve the body's response to the vaccine. CoTend-BXBB…

    Stage

    Phase 1

    Ages

    40 to 64

    Site

    UCLA Westwood, Los Angeles, California

    Locations

    2 in total

    Run by

    Kara Chew

    See if you can join NCT06810934 on ClinicalTrials.gov

12. Respiratory Virus Sampling and Repository

    Background: Respiratory viruses, like the flu or COVID-19, cause significant illness and death worldwide. Researchers want to collect samples from people with respiratory virus infections. The samples in this natural history study will be used in future research. Objective: To obtain samples from p…

    Stage

    Not phased

    Ages

    3 and older

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Locations

    2 in total

    Run by

    National Institute of Allergy and Infectious Diseases (NIAID)

    See if you can join NCT05266222 on ClinicalTrials.gov

13. Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

    This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19.

    Stage

    Phase 3

    Ages

    Any age

    Site

    City of Hope cancer Center, Duarte, California

    Locations

    28 in total

    Run by

    Ansun Biopharma, Inc.

    See if you can join NCT03808922 on ClinicalTrials.gov

14. REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

    Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Locations

    5 in total

    Run by

    Duke University

    See if you can join NCT05218083 on ClinicalTrials.gov

15. The Impact of COVID-19 on Maternal and Neonatal Outcomes

    The novel coronavirus (SARS-CoV-2) infection (COVID-19) has caused a worldwide pandemic. There is still much that is unknown regarding the virus, especially its effects on pregnancy, the fetus, and the neonate. This study seeks to evaluate adverse pregnancy and neonatal outcomes related to COVID-19…

    Stage

    Not phased

    Ages

    14 to 55

    Site

    Johns Hopkins Hospital, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT05197621 on ClinicalTrials.gov

16. A Study of Post COVID-19 Mechanisms for Chronic Lung Sequelae

    The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic Minnesota, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06006884 on ClinicalTrials.gov

17. Impact of the Coronavirus (COVID-19) on Patients With Cancer

    The purpose of this study is to understand the impact of COVID-19 on patients with cancer through a survey.

    Stage

    Not phased

    Ages

    18 to 99

    Site

    Stanford University School of Medicine, Stanford, California

    Run by

    Stanford University

    See if you can join NCT04330521 on ClinicalTrials.gov

18. Arginine Replacement Therapy in COVID-19

    This study aims to investigate if receiving doses of arginine (a protein in the body) will improve mitochondria function in children with COVID-19. The study will be performed at the Children's Healthcare of Atlanta, Arthur M. Blank Hospital. Patients will be randomized to receive one of three dose…

    Stage

    Phase 2

    Ages

    3 to 21

    Site

    Children's Healthcare of Atlanta (CHOA), Arthur M. Blank, Atlanta, Georgia

    Run by

    Emory University

    See if you can join NCT05855330 on ClinicalTrials.gov

19. ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers

    The novel coronavirus (SARS-CoV-2) has spread all around the world and testing has posed a challenge globally. Health care providers are highly exposed and are an important group to test. On top of these concerns, health care workers are also stressed by the needs on responders in the COVID-19 cris…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NewYork-Presbyterian Hosptial/Columbia University Irving Medical Center, New York, New York

    Run by

    Columbia University

    See if you can join NCT04367857 on ClinicalTrials.gov

20. Dysbiosis & Long COVID

    The SARS-CoV-2 virus causes COVID-19, which ranges from mild initial symptoms to severe multi-organ dysfunction. While some patients recover to their baseline states, others develop a long COVID, or post-acute sequelae of SARS-CoV-2 (PASC) consisting of symptoms persisting >2-6 months post-infectio…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    The University of Chicago, Chicago, Illinois

    Run by

    University of Chicago

    See if you can join NCT06825819 on ClinicalTrials.gov

21. Positron Emission Tomography (PET) Imaging of Thrombosis

    The purpose of the study is to evaluate a new radiotracer called 64Cu-FBP8 for PET-MR imaging of thrombosis. The tracer has the potential of detecting thrombosis anywhere in the body, for instance in the left atrial appendage of patients with atrial fibrillation, and thereby may provide a non-invas…

    Stage

    Phase 1

    Ages

    18 to 85

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT03830320 on ClinicalTrials.gov

22. Cardiac Magnetic Resonance Tissue Characterization in COVID-19 Survivors

    The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in COVID-19 survivors. If successful, the research will allow us to identif…

    Stage

    Not phased

    Ages

    18 and older

    Site

    New York Presbyterian-Brooklyn Methodist Hospital, Brooklyn, New York

    Locations

    3 in total

    Run by

    Weill Medical College of Cornell University

    See if you can join NCT05164744 on ClinicalTrials.gov

23. Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine

    The primary objective of this effort will be to optimize and operationalize innovative passive surveillance systems and in parallel, the effort will identify, evaluate, and transition groundbreaking new technologies in diagnostics for operationalization. To meet the objective and execute the delive…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    Brooke Army Medical Center, Fort Sam Houston, Texas

    Run by

    The Geneva Foundation

    See if you can join NCT06402318 on ClinicalTrials.gov

24. Influenza & COVID-19 Obstetric and Perinatal Epidemiology Study in India

    This study will be conducted as a prospective cohort study, enrolling all eligible women in their first trimester of pregnancy during a baseline visit during week 6-13 of pregnancy at Government Medical College Hospital, Nagpur. The Hospital provides primary, secondary, and tertiary care and the ob…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Boston University School of Public Health, Global Health, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Boston University

    See if you can join NCT06168019 on ClinicalTrials.gov

25. Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement

    The goal of this study is to reduce morbidity and mortality from COVID-19 amongst people who are detained in and work in correctional facilities. The overall objective is to identify feasible and effective interventions to improve vaccine uptake in correctional facilities and study the effectivenes…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Pennsylvannia Department of Corrections, Schwenksville, Pennsylvania

    Run by

    Yale University

    See if you can join NCT05796505 on ClinicalTrials.gov