Congenital Diaphragmatic Hernia Clinical Trials

18 studies are recruiting for congenital diaphragmatic hernia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

Search these by distance from you

By city

Ann Arbor, Michigan 3 Cincinnati, Ohio 3 Houston, Texas 3 Salt Lake City, Utah 3

Studies now recruiting

  1. De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia

    The purpose of this study is to determine if de-implementation of inhaled nitric oxide (iNO) in the post-natal resuscitation/stabilization phase affects the composite outcome of extracorporeal life support (ECLS) use and/or mortality, as well as ECLS use, mortality, and/or oxygenation in congenital…

    Stage
    Phase 4
    Ages
    0 to 0
    Site
    University of Alabama & Children's Hospital of Alabama (UAB-CoA), Birmingham, Alabama
    Locations
    19 in total
    Run by
    The University of Texas Health Science Center, Houston

    See if you can join NCT05213676 on ClinicalTrials.gov

  2. Safety and Efficacy of FETO in CDH: A Phase III Trial

    Congenital diaphragmatic hernia (CDH) is a birth defect characterized by the development of a hole in the diaphragm, the breathing muscle that separates the chest from the abdomen. As a result, organs in the abdomen can move into the chest and press on the developing lungs. This prevents the lungs …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
    Run by
    Holly L Hedrick, MD

    See if you can join NCT06884423 on ClinicalTrials.gov

  3. Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Congenital Diaphragmatic Hernia (CDH)

    The purpose of the study is to determine if babies with left or right-sided CDH that undergo the FETO procedure survive more often and have fewer long-term complications than babies that have similar left or right-sided CDH that elect not to have the FETO procedure performed during pregnancy.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    Dr Erin Perrone

    See if you can join NCT07577414 on ClinicalTrials.gov

  4. Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH

    This registry study aims to confirm that FETO increases neonatal survival to discharge and reduces long-term morbidity in fetuses with isolated left CDH and o/e LHR < 30%, or isolated right CDH and o/e LHR ≤ 45%, compared to those receiving standard care. This prospective registry plans to enroll 8…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Johns Hopkins Hospital, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT07166172 on ClinicalTrials.gov

  5. Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

    The purpose of this research is to gather information on the safety and effectiveness of a procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO) at Mayo Clinic. The intent of the FETO procedure is to improve development of the lungs in fetuses diagnosed with severe congenital diaphragma…

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Mayo Clinic Minnesota, Rochester, Minnesota
    Run by
    Mauro H. Schenone

    See if you can join NCT05962346 on ClinicalTrials.gov

  6. Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO)

    The purpose of this research is to gather information on the safety and effectiveness of a new procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO).

    Stage
    Not phased
    Ages
    18 to 50
    Site
    University of Miami, Miami, Florida
    Locations
    2 in total
    Run by
    Rodrigo Ruano

    See if you can join NCT03138863 on ClinicalTrials.gov

  7. Fetal Endotracheal Occlusion (FETO) in the Resolution of Pulmonary Hypertension in Fetuses With Severe CDH

    Congenital diaphragmatic hernia (CDH) occurs when the diaphragm fails to fully fuse and leaves a portal through which abdominal structures can migrate into the thorax. In the more severe cases, the abdominal structures remain in the thoracic cavity and compromise the development of the lungs. Infan…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    Texas Childrens Hospital, Houston, Texas
    Run by
    Michael A Belfort

    See if you can join NCT03980717 on ClinicalTrials.gov

  8. Fetal Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia

    The purpose of the study is to study the efficacy of fetal endoscopic tracheal occlusion (FETO) in cases of severe congenital diaphragmatic hernia (CDH). This study will also collect safety and effectiveness data for the off-label use of the FETO Goldballoon (the balloon that will be inserted into …

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Lucile Packard Children's Hospital, Stanford, California
    Run by
    Yair Blumenfeld

    See if you can join NCT05461222 on ClinicalTrials.gov

  9. Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)

    Despite advances in prenatal diagnosis and postnatal therapies, including ECMO (Extracorporeal Membrane Oxygenation), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity and mortality rates for babies with severe CDH remain high. The ratio…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California San Francisco Fetal Treatment Center, San Francisco, California
    Run by
    Hanmin Lee

    See if you can join NCT04583644 on ClinicalTrials.gov

  10. Trial of FETO for Severe Congenital Diaphragmatic Hernia

    This is a single site pilot trial to study the feasibility of Fetoscopic Endoluminal Tracheal Occlusion (FETO) therapy in the most severe group of fetuses with congenital diaphragmatic hernia (CDH) at Ann \& Robert H. Lurie Children's Hospital of Chicago (Lurie Children's). This procedure aims to i…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
    Run by
    Aimen F. Shaaban, MD

    See if you can join NCT05450653 on ClinicalTrials.gov

  11. Fetal Endoscopic Tracheal Occlusion for CDH (CDH)

    This is a single site pilot trial to assess the feasibility and safety of treating severe CDH with Fetal Endoscopic Tracheal Occlusion with the Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) at UC Davis Medical Center. The study will enroll pregna…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UC Davis Medical Center, Sacramento, California
    Run by
    University of California, Davis

    See if you can join NCT05421676 on ClinicalTrials.gov

  12. Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science

    The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of con…

    Stage
    Not phased
    Ages
    Any age
    Site
    Rush Hospital, Chicago, Illinois
    Locations
    14 in total
    Run by
    Columbia University

    See if you can join NCT00950118 on ClinicalTrials.gov

  13. Safety and Efficacy of FETO in CDH Phase III

    Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses and standard of care control group

    Stage
    Phase 3
    Ages
    18 to 50
    Site
    Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio
    Run by
    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT07187206 on ClinicalTrials.gov

  14. North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia

    The purpose of this study is to evaluate successful placement and removal of Fetoscopic Endoluminal Tracheal Occlusion (FETO) device in cases of intrathoracic liver herniation with isolated left congenital diaphragmatic hernia (LCDH) with Observed/Expected (O/E) Lung to Head Circumference Ratio (LH…

    Stage
    Not phased
    Ages
    18 and older
    Site
    The University of Texas Health Science Center at Houston, Houston, Texas
    Run by
    The University of Texas Health Science Center, Houston

    See if you can join NCT06739356 on ClinicalTrials.gov

  15. Fetoscopic Endoluminal Tracheal Occlusion

    The purpose of this research study is to see if the FETO surgery and FETO release (surgery to remove the device) works and is safe for babies with severe right or left Congenital Diaphragmatic Hernia (CDH). CDH is a condition in which a hole in the baby's diaphragm allows the abdominal organs to mo…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Children's Hospital Colorado, Aurora, Colorado
    Run by
    University of Colorado, Denver

    See if you can join NCT03674372 on ClinicalTrials.gov

  16. Feto-Endoscopic Tracheal Occlusion (FETO) for Severe Congenital Diaphragmatic Hernia

    Tracheal occlusion IDE approved by FDA for congenital diaphragmatic hernia fetuses.

    Stage
    Not phased
    Ages
    18 to 50
    Site
    Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio
    Run by
    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT02986087 on ClinicalTrials.gov

  17. High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia

    The purpose of this study is to conduct a prospective study of all congenital diaphragmatic hernia (CDH) neonates managed at the University of Utah newborn intensive care unit (NICU) and Primary Children's Hospital NICU that required mechanical ventilation at birth. As both high frequency jet venti…

    Stage
    Not phased
    Ages
    Any age
    Site
    Primary Children's Hospital, Salt Lake City, Utah
    Locations
    2 in total
    Run by
    University of Utah

    See if you can join NCT04774848 on ClinicalTrials.gov

  18. A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)

    Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 US live births, similar to the incidence seen within the Utah Birth Defects cohort. The diaphragmatic defect compromises lung growth and alters pulmonary vascular development. This is reflected postnatally as respiratory failur…

    Stage
    Phase 2
    Ages
    Any age
    Site
    Primary Children's Hospital, Salt Lake City, Utah
    Run by
    University of Utah

    See if you can join NCT05201144 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.