Colorectal Neoplasms Clinical Trials

21 studies are recruiting for colorectal neoplasms in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

   Background: - Recent advances in cancer research have led to new therapies to treat the disease. It is important to continue these advances and discover new ones. To do that, researchers need tissue samples from solid tumors. This study will collect such samples from people already scheduled to hav…

   Stage

   Not phased

   Ages

   2 and older

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT01915225 on ClinicalTrials.gov

2. A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

   The purpose of this study is to find out whether the study drug, Sofetabart Mipitecan (LY4170156), is safe, tolerable and effective in participants with advanced solid tumors. The study is conducted in three parts - phase Ia (dose-escalation, dose-optimization), phase Ib (dose-expansion), and phase…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   HonorHealth, Scottsdale, Arizona

   Locations

   24 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT06400472 on ClinicalTrials.gov

3. A Study of LY4257496 in Participants With Cancer (OMNIRAY)

   The main purpose of this study is to evaluate safety, tolerability, and efficacy of LY4257496 alone and as part of relevant standard of care (SOC) combination therapy in participants with Gastrin-releasing Peptide Receptor (GRPR)-positive advanced cancer, including but not limited to breast, colore…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   City of Hope, Duarte, California

   Locations

   33 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07114601 on ClinicalTrials.gov

4. A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

   This is a study of LY4337713 in participants with certain types of cancer that is advanced or has spread. Participants must have cancer with high levels of a protein called fibroblast activation protein (FAP). The purpose of this study is to evaluate safety, side effects, and efficacy of LY4337713.…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Hoag Memorial Hospital Presbyterian, Newport Beach, California

   Locations

   30 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07213791 on ClinicalTrials.gov

5. PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

   Background: One way to treat liver cancer is to deliver chemotherapy drugs only to the liver (and not to the whole body). Researchers want to see if adding the drug PDS01ADC can improve the treatment. The drug triggers the immune system to fight cancer.<TAB> Objective: To see if treatment with HAIP…

   Stage

   Phase 2

   Ages

   18 to 120

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT05286814 on ClinicalTrials.gov

6. PRE-ISPY Phase I/II Oncology Platform Program

   PRE-ISPY Phase I/II (I-SPY-P1) is an open-label, multisite platform study with multiple ongoing drug regimen arms added by protocol amendment which is designed to evaluate single agents or combinations in locally advanced, incurable, or metastatic solid tumors and/or oligometastatic malignancy and/…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   The University of Alabama at Birmingham O'Neal Comprehensive Cancer Center, Birmingham, Alabama

   Locations

   10 in total

   Run by

   QuantumLeap Healthcare Collaborative

   See if you can join NCT05868226 on ClinicalTrials.gov

7. A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

   The purpose of this study is to compare how long the participants are disease-free (progression-free survival) when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovorin, oxaliplatin (mFOLFOX6) or 5-fluorouracil, leucovorin calcium (folin…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Banner MD Anderson Cancer Center, Gilbert, Arizona

   Locations

   239 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06662786 on ClinicalTrials.gov

8. A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers

   The purpose of this study is to determine the putative recommended phase 2 dose(s) (RP2Ds) and best way to take (optimal route of administration) JNJ-89402638 and to determine the safety of JNJ-89402638 at the RP2D(s) in participants with metastatic colorectal cancer (mCRC) and metastatic gastric c…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   University of Arizona Cancer Center, Tucson, Arizona

   Locations

   12 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06663319 on ClinicalTrials.gov

9. A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

   The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fluorouracil, leucovorin calcium (folinic acid) or levoleucovo…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Ironwood Cancer and Research Center, Chandler, Arizona

   Locations

   251 in total

   Run by

   Janssen Research & Development, LLC

   See if you can join NCT06750094 on ClinicalTrials.gov

10. Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

    Background: Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or reduces metastasis. Researchers hope a new drug can help. It stops cancer cells from growing and spreading further and possibly shrink cancer l…

    Stage

    Phase 1

    Ages

    12 to 120

    Site

    University of Kansas, Fairway, Kansas

    Locations

    2 in total

    Run by

    National Cancer Institute (NCI)

    See if you can join NCT04222413 on ClinicalTrials.gov

11. A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

    A first in human study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of BLU-924 / SAR449336, a pan-KRAS inhibitor, in participants with advanced Pancreatic Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer harboring KRAS mutations.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Florida Cancer Specialists & Research Institute - Sarasota, Sarasota, Florida

    Locations

    3 in total

    Run by

    Blueprint Medicines Corporation

    See if you can join NCT07629960 on ClinicalTrials.gov

12. Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

    The purpose of this study is to learn more about a new medicine called PF-08634404, and how well it works in people with cancer of the colon or rectum (CRC)). The goal is to understand if the new study medicine, combined with chemotherapy that is approved for colorectal cancer, can help people whos…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Ironwood Cancer & Research Centers, Chandler, Arizona

    Locations

    308 in total

    Run by

    Pfizer

    See if you can join NCT07222800 on ClinicalTrials.gov

13. Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

    This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

    Stage

    Not phased

    Ages

    65 to 82

    Site

    University of Arizona, Tucson, Arizona

    Locations

    24 in total

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT05612347 on ClinicalTrials.gov

14. A Study of DM002 in Patients With Advanced Solid Tumors

    The goal of study： The study has two parts: Part 1 Dose Escalation and Part 2 Dose Expansion. In Part 1, a few participants will receive the lowest dose of study drug. The study team will make sure it is safe and tolerated before enrolling new participants at a higher dose of study drug. There will…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    University of California San Francisco Cancer Center, San Francisco, California

    Locations

    7 in total

    Run by

    Xadcera Biopharmaceutical (Suzhou) Co., Ltd.

    See if you can join NCT06751329 on ClinicalTrials.gov

15. A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

    This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participants take this combination of drugs. A side effect is anythin…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Palo Verde Hematology Oncology, Glendale, Arizona

    Locations

    366 in total

    Run by

    Seagen, a wholly owned subsidiary of Pfizer

    See if you can join NCT05253651 on ClinicalTrials.gov

16. A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

    This clinical trial is studying advanced solid tumors. Solid tumors are cancers that start in a part of your body like your lungs or liver instead of your blood. Once tumors have grown bigger in one place but haven't spread, they're called locally advanced. If your cancer has spread to other parts …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Mayo Clinic Hospital, Phoenix, Arizona

    Locations

    48 in total

    Run by

    Seagen, a wholly owned subsidiary of Pfizer

    See if you can join NCT06131840 on ClinicalTrials.gov

17. Early Onset Colorectal Cancer Detection

    Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagno…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    City of Hope Medical Center, Duarte, California

    Locations

    13 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT06342401 on ClinicalTrials.gov

18. Early Detection of Advanced Adenomas and Colorectal Cancer

    This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

    Stage

    Not phased

    Ages

    18 and older

    Site

    City of Hope Medical Center, Monrovia, California

    Locations

    6 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT06342440 on ClinicalTrials.gov

19. Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

    The purpose of this study is to find out how cancer treatments (chemotherapy and/or radiation therapy) affect reproductive and sexual health in people with early onset colorectal cancer. The study researchers will observe and track changes in hormone levels and in sexual and reproductive health in …

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT04812912 on ClinicalTrials.gov

20. DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment

    To prospectively evaluate the efficacy and safety of DPYD-guided dosing strategies in a real-world clinical setting, specifically by comparing the incidence of severe (Grade 3 and 4) fluoropyrimidine-related toxicities of heterozygous DPYD variant patients assigned to DPYD-guided reduced dosing ver…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    RWJBarnabas Health Clara Maas Medical Center, Belleville, New Jersey

    Locations

    12 in total

    Run by

    Rutgers, The State University of New Jersey

    See if you can join NCT07158164 on ClinicalTrials.gov

21. Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

    The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.

    Stage

    Phase 3

    Ages

    18 and older

    Site

    City of Hope National Medical Center, Duarte, California

    Locations

    11 in total

    Run by

    Surgimab

    See if you can join NCT03659448 on ClinicalTrials.gov