Colorectal Cancer Clinical Trials

163 studies are recruiting for colorectal cancer in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 4

1. A Study to Test DSP107 in Combination With Atezolizumab in Comparison With Fruquintinib as a New Treatment for Colorectal Cancer.

   This clinical study is testing whether a new combination of medicines (DSP107 and atezolizumab) is more effective and safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). Participants will be randomly assigned to receive one…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Colorado Hospital- Anschutz Cancer Center Pavillion (ACP), Aurora, Colorado

   Locations

   18 in total

   Run by

   Kahr Bio Australia Pty Ltd

   See if you can join NCT07235293 on ClinicalTrials.gov

2. Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer

   This is a 2-arm, noncomparative phase 2 trial designed to evaluate treatment outcomes with or without the addition of ciprofloxacin, metronidazole, and aspirin to first-line chemotherapy for patients with stage IV colorectal cancer (CRC).

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Virginia Cancer Institute (VCI), Richmond, Virginia

   Locations

   2 in total

   Run by

   Virginia Commonwealth University

   See if you can join NCT06728072 on ClinicalTrials.gov

3. Novel Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer

   The overall objective of this study is to learn whether a newly developed couple-based mindfulness program (Mindful PaCT) is practical to complete (feasible), helpful and well-received (acceptable), and relevant for patients with metastatic colorectal cancer (mCRC) and their partners.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Colorado Hospital, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07759921 on ClinicalTrials.gov

4. A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

   This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with unresectable locally advanced or metastatic solid tumors.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   ULCA, Los Angeles, California

   Locations

   21 in total

   Run by

   ArriVent BioPharma, Inc.

   See if you can join NCT07066657 on ClinicalTrials.gov

5. A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

   This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants with advanced solid tumors that are antigen-rich.

   Stage

   Phase 1

   Ages

   18 and older

   Site

   AdventHealth Celebration, Celebration, Florida

   Locations

   19 in total

   Run by

   Marengo Therapeutics, Inc.

   See if you can join NCT05592626 on ClinicalTrials.gov

6. Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

   To identify Black individuals who are eligible for genetic testing through trusted community organizations, and to connect Black individuals and their families to genetic testing and counseling so that they can know their cancer risk and how to decrease it.

   Stage

   Not phased

   Ages

   18 and older

   Site

   MD Anderson Cancer Center, Houston, Texas

   Run by

   M.D. Anderson Cancer Center

   See if you can join NCT05694559 on ClinicalTrials.gov

7. Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy

   The purpose of this study is to evaluate the Colorectal Balloon Tube (hereinafter referred to as COLO-BT™) device, a single use, temporary intraluminal bypass device, intended to reduce contact of fecal content with an anastomotic site, following colorectal surgery (open or laparoscopic)

   Stage

   Not phased

   Ages

   19 to 80

   Site

   Jacobs School of Medicine & Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York

   Locations

   3 in total

   Run by

   JSR Medical Co., Ltd.

   See if you can join NCT05826743 on ClinicalTrials.gov

8. IDOV-Immune for Advanced Solid Tumors

   This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cells and have the potent…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   5 in total

   Run by

   ViroMissile, Inc.

   See if you can join NCT06910657 on ClinicalTrials.gov

9. Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

   The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to make these available for future use for molecular and mechanistic studi…

   Stage

   Not phased

   Ages

   18 and older

   Site

   NYP/Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06096688 on ClinicalTrials.gov

10. A Study of Meaning-Centered Therapy for Mexican Adults With Advanced Cancer

    The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, i…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Cancer Center, New York, New York

    Locations

    2 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07225309 on ClinicalTrials.gov

11. KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

    Phase 1b study evaluating the efficacy and immune response to a synthetic long peptide mutant KRAS vaccine (SPL mKRASvax) combined with Balstilimab and Botensilimab for unresectable or metastatic mismatch repair-proficient (MMR-p) colorectal cancer (mCRC) or unresectable or metastatic MMR-p pancrea…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT06411691 on ClinicalTrials.gov

12. Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

    The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of [177Lu]Lu-NNS309 and the safety, dosimetry and imaging properties of [68Ga]Ga-NNS309 in patients aged ≥ 18 years with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC), non-…

    Stage

    Phase 1

    Ages

    18 to 100

    Site

    Uni of Alabama at Birmingham, Birmingham, Alabama

    Locations

    29 in total

    Run by

    Novartis Pharmaceuticals

    See if you can join NCT06562192 on ClinicalTrials.gov

13. Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

    This Phase 1, multi-center, open-label, dose escalation and dose optimization study is designed to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), and preliminary clinical activity of MOMA-341 administered orally as a single agent or combination therapy in patients w…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Investigative Site #132, Phoenix, Arizona

    Locations

    15 in total

    Run by

    MOMA Therapeutics

    See if you can join NCT06974110 on ClinicalTrials.gov

14. The Florida ASCENT Study

    The goal of this clinical trial is to adapt, implement, and evaluate MyCarePulse and ASCENT patient navigator to overcome barriers to care among patients with cancer. The main hypotheses it aims to test are: * At the patient level, the intervention will result in higher levels of food security, sel…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    University of Florida, Gainesville, Florida

    Run by

    University of Florida

    See if you can join NCT07042243 on ClinicalTrials.gov

15. A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

    The purpose of this study is to learn about the safety and effects of the study medicine when given alone or together with other anti-cancer therapies. Anti-cancer therapy is a type of treatment to stop the growth of cancer. This study also aims to find the best amount of study medication. This stu…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California

    Locations

    13 in total

    Run by

    Pfizer

    See if you can join NCT07318805 on ClinicalTrials.gov

16. Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome

    The purpose of the study is to see if our education materials help people at risk for Lynch syndrome decide about seeking genetic services. Untested relatives of patients with Lynch syndrome will be recruited to complete a baseline survey and will be randomized to receive either the an information …

    Stage

    Not phased

    Ages

    18 and older

    Site

    UAB, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT07106359 on ClinicalTrials.gov

17. Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer

    The purpose of this study is to evaluate the safety and clinical activity of combining cemiplimab, cemiplimab/fianlimab, or cemiplimab/REGN7075 with capecitabine/oxaliplatin (CAPOX) for the neoadjuvant treatment of patients with microsatellite stable (MSS) locally advanced rectal cancer (T2 node-po…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

    Run by

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

    See if you can join NCT07281768 on ClinicalTrials.gov

18. A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

    The purpose of this study is to evaluate the safety and efficacy of two dose levels of ONO-4578 with Opdivo® when added to mFOLFOX6 and bevacizumab versus SOC as first-line treatment for advanced CRC.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Mayo Clinic Arizona, Phoenix, Arizona

    Locations

    39 in total

    Run by

    Ono Pharmaceutical Co., Ltd.

    See if you can join NCT06948448 on ClinicalTrials.gov

19. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

    This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels in cancer survivors (recently completing prior treatment regimens) or patients who have received whole bra…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California

    Run by

    University of California, Irvine

    See if you can join NCT06580002 on ClinicalTrials.gov

20. PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

    This is a hybrid decentralized, single-arm, interventional study designed to evaluate the impact of precision medicine navigation and reflexive expert review of next-generation sequencing (NGS) for patients with stage IV solid tumor malignancies (breast, lung, colorectal, and bladder cancers). The …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina

    Run by

    UNC Lineberger Comprehensive Cancer Center

    See if you can join NCT06896162 on ClinicalTrials.gov

21. A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

    The purpose of this study is to evaluate the efficacy and safety of zanidatamab for the treatment of participants with previously treated solid tumors that have Human Epidermal Growth Factor Receptor 2 (HER2) Immunohistochemistry (IHC) 3+ overexpression.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Rocky Mountain Cancer Center, Littleton, Colorado

    Locations

    28 in total

    Run by

    Jazz Pharmaceuticals

    See if you can join NCT06695845 on ClinicalTrials.gov

22. CARE Tool Study Aim 3

    This study is a multi-site randomized trial to study the implementation of the CARE Tool and evaluate the CARE Tool. The CARE Tool is a web-based tool that gives people information about cancer care costs, health insurance, and resources to help with costs. Overall, the study aims to help patients …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Alton Memorial Hospital, Alton, Illinois

    Locations

    3 in total

    Run by

    Washington University School of Medicine

    See if you can join NCT07296887 on ClinicalTrials.gov

23. Stage II/III Colorectal Cancer Recurrence

    This study will develop an assay to predict disease recurrence in patients with stage II/III CRC after receiving adjuvant chemotherapy, using genome-wide DNA methylation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    City of Hope Medical Center, Monrovia, California

    Locations

    4 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT06314958 on ClinicalTrials.gov

24. Early Onset Colorectal Cancer Detection

    Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagno…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    City of Hope Medical Center, Duarte, California

    Locations

    13 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT06342401 on ClinicalTrials.gov

25. Early Detection of Advanced Adenomas and Colorectal Cancer

    This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

    Stage

    Not phased

    Ages

    18 and older

    Site

    City of Hope Medical Center, Monrovia, California

    Locations

    6 in total

    Run by

    City of Hope Medical Center

    See if you can join NCT06342440 on ClinicalTrials.gov