Cognitive Dysfunction Clinical Trials

26 studies are recruiting for cognitive dysfunction in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Longevity Metrics AI/ML Development Study

   This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy. Longevity Metrics collects a battery of clinical tests on each participant, in whole or in part, and follows every participant for life. The sit-to-rise tes…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07808619 on ClinicalTrials.gov

2. 100-Year Human Aging Study

   The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07563777 on ClinicalTrials.gov

3. A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

   The main purpose of this study is to evaluate whether treatment with donanemab slows the progression of cognitive (how we think, learn, remember, pay attention, and make decisions) and functional (how we are able to perform daily activities) decline. For each participant, the study will last one an…

   Stage

   Phase 2

   Ages

   55 to 85

   Site

   TrialSphere Corp, Chandler, Arizona

   Locations

   72 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07589595 on ClinicalTrials.gov

4. Human Observatory Study

   The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level. Individual multi-system clinical data from enrolled participants are linked to a con…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   Longevity Metrics, Inc.

   See if you can join NCT07646782 on ClinicalTrials.gov

5. Health Ahead Comparative Effectiveness Study

   The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and r…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Longevity Metrics, Boulder, Colorado

   Run by

   William Brandenburg, MD

   See if you can join NCT07669168 on ClinicalTrials.gov

6. Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

   The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute. This information will be used to identify helpful tests to diagnose individuals at risk for developing difficulti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Parkview Cancer Institute, Fort Wayne, Indiana

   Run by

   Joseph McCollom

   See if you can join NCT05014399 on ClinicalTrials.gov

7. ME/CFS Brain Fog: Cognitive Rehabilitation Trial

   The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog. All participants will be screened for eligibility prior to participation. Most of the procedures will take place over a phone call or secure …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT07523113 on ClinicalTrials.gov

8. Interventions in Mathematics and Cognitive Skills

   The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

   Stage

   Not phased

   Ages

   6 to 12

   Site

   Stanford Cognitive and Systems Neuroscience Laboratory, Palo Alto, California

   Run by

   Stanford University

   See if you can join NCT05201534 on ClinicalTrials.gov

9. High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV

   This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whether 16 weeks of structured high-intensity interval training (HIIT) can overcome vascular and cognit…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Run by

   University of Alabama at Birmingham

   See if you can join NCT05965518 on ClinicalTrials.gov

10. The Better, Harder, Faster, Stronger Study

    The purpose of this study is to evaluate changes in the electronic Frailty Index (eFI) score following 3-4 cycles of neoadjuvant chemotherapy (NACT) in participants with advanced ovarian and endometrial cancer.

    Stage

    Not phased

    Ages

    55 and older

    Site

    Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT07220512 on ClinicalTrials.gov

11. Polyphenols and Cognitive Decline

    Globally, populations are aging thereby increasing healthcare burden, overall cognitive impairment, and dementia including Alzheimers diseases (AD). The lack of effective treatments makes it essential to develop new strategies for healthy cognitive aging, including interventions to slow or prevent …

    Stage

    Not phased

    Ages

    50 and older

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06507254 on ClinicalTrials.gov

12. Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

    Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests wheth…

    Stage

    Not phased

    Ages

    65 and older

    Site

    University of Florida, Gainesville, Florida

    Locations

    2 in total

    Run by

    University of Florida

    See if you can join NCT05830942 on ClinicalTrials.gov

13. Brain Stimulation and Cognitive Training for MCI

    This is a randomized clinical trial of a treatment that combines non-invasive brain stimulation with computerized cognitive training (CCT) for people with mild cognitive impairment (MCI). The form of brain stimulation used in this study is accelerated intermittent theta burst stimulation (iTBS). Al…

    Stage

    Not phased

    Ages

    60 to 85

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07526740 on ClinicalTrials.gov

14. Stem Cell Therapy for Early Alzheimer's Disease

    The goal of this clinical trial is to learn if stem cell therapy works to treat brain inflammation in adults. Inflammation in the brain may be involved in adults who have memory or thinking problems. The stem cells will be taken from participant's fat samples, processed and given back to participan…

    Stage

    Phase 1

    Ages

    60 to 80

    Site

    The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas

    Run by

    Paul E Schulz

    See if you can join NCT06775964 on ClinicalTrials.gov

15. Long COVID Brain Fog: Cognitive Rehabilitation Trial

    This study will compare two approaches to cognitive rehabilitation in adults with long COVID with persistent, mild to moderate, cognitive impairment. One approach will feature (A) web-based computer "games" that trains how quickly individuals process information that they receive through their sens…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Alabama at Birmingham, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06095297 on ClinicalTrials.gov

16. taVNS + CCT for Neurocognitive Rehab

    The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood. Participants will self-administer these treatment in their homes and undergo pre- and post-trea…

    Stage

    Not phased

    Ages

    45 to 80

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07517237 on ClinicalTrials.gov

17. Cognitive Remediation

    The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aim…

    Stage

    Not phased

    Ages

    60 and older

    Site

    UConn Health, Farmington, Connecticut

    Run by

    Cutter Lindbergh

    See if you can join NCT07171450 on ClinicalTrials.gov

18. ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults

    This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults with mild cognitive impairment and APOE4 genotype. By targeting the e…

    Stage

    Phase 2

    Ages

    60 and older

    Site

    Rutgers - Institute for Health, New Brunswick, New Jersey

    Run by

    Michal Schnaider Beeri, Ph.D.

    See if you can join NCT07392723 on ClinicalTrials.gov

19. Tennessee Alzheimer's Project

    The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Cor…

    Stage

    Not phased

    Ages

    60 and older

    Site

    Vanderbilt University Medical Center, Nashville, Tennessee

    Run by

    Vanderbilt University Medical Center

    See if you can join NCT05372172 on ClinicalTrials.gov

20. HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

    The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer or a brain tumor (CA participants). This study will also assess the abi…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Dartmouth-Health Lebanon, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06930846 on ClinicalTrials.gov

21. Strengthening Neuro-Cognitive Skills for Success in School, Work and Beyond

    For many Veterans, success in achieving goals at work, school and in other aspects of life are top priorities. The abilities to regulate attention, remember key information, and stay calm and on track are fundamental to this success. Unfortunately, Veterans who have experienced a traumatic brain in…

    Stage

    Not phased

    Ages

    21 to 60

    Site

    VA Northern California Health Care System, Mather, CA, Sacramento, California

    Run by

    VA Office of Research and Development

    See if you can join NCT04109027 on ClinicalTrials.gov

22. Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside

    This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild cognitive impairment and mild Alzheimer's dementia.

    Stage

    Not phased

    Ages

    18 to 89

    Site

    McLean Hospital, Belmont, Massachusetts

    Run by

    Mclean Hospital

    See if you can join NCT05245903 on ClinicalTrials.gov

23. HOBSCOTCH-MS-Efficacy Trial

    The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-MS to improve the quality of life and cognitive function in Service Members, Veterans and civilians who have multiple sclerosis with cognitive and memory problems (MS participants). This study will also ass…

    Stage

    Not phased

    Ages

    20 to 75

    Site

    Dartmouth-Health Lebanon, Lebanon, New Hampshire

    Run by

    Dartmouth-Hitchcock Medical Center

    See if you can join NCT06951919 on ClinicalTrials.gov

24. Surviving Daily Life

    The primary goal of this project is to evaluate the feasibility of a 14-day mobile daily diary study among racially diverse breast cancer survivors. Further, the investigators will examine the validity and reliability of the daily stress and daily cognitive performance measures among breast cancer …

    Stage

    Not phased

    Ages

    40 and older

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT07054723 on ClinicalTrials.gov

25. Cognitive Rehabilitation for Veterans With MDD-related Cognitive Functioning Deficits

    Individuals with depression often describe difficulties with memory, attention, concentration, and overall cognitive functioning, which can persist even after mood episodes get better, and can affect treatment and health outcomes. The primary objective of this pilot clinical trial is to evaluate th…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Portland VA Medical Center, Portland, Oregon

    Run by

    Portland VA Medical Center

    See if you can join NCT06728774 on ClinicalTrials.gov