Cognitive Change Clinical Trials

17 studies are recruiting for cognitive change in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Cognitive Impact of Neoadjuvant Chemotherapy for Gynecologic Cancers

   The purpose of this research is to assess several components of cognition in patients recently diagnosed with advanced epithelial ovarian cancer and who will be undergoing neoadjuvant chemotherapy for treatment of the cancer. 18 participants will be enrolled and can expect to be on study for approx…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UW Carbone Cancer Center, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07125209 on ClinicalTrials.gov

2. Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy

   The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute. This information will be used to identify helpful tests to diagnose individuals at risk for developing difficulti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Parkview Cancer Institute, Fort Wayne, Indiana

   Run by

   Joseph McCollom

   See if you can join NCT05014399 on ClinicalTrials.gov

3. Interventions in Mathematics and Cognitive Skills

   The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

   Stage

   Not phased

   Ages

   6 to 12

   Site

   Stanford Cognitive and Systems Neuroscience Laboratory, Palo Alto, California

   Run by

   Stanford University

   See if you can join NCT05201534 on ClinicalTrials.gov

4. Effectiveness of Cognitive Training in Older and Younger Adults

   The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research over 4 to 8 weeks.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of California, Riverside, Riverside, California

   Locations

   3 in total

   Run by

   University of Wisconsin, Madison

   See if you can join NCT06375681 on ClinicalTrials.gov

5. Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

   This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomar…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill, North Carolina

   Run by

   UNC Lineberger Comprehensive Cancer Center

   See if you can join NCT06727773 on ClinicalTrials.gov

6. Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

   Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. …

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT05457725 on ClinicalTrials.gov

7. Exercise to Improve Brain Health in Older African Americans

   The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question[s] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Bala…

   Stage

   Phase 2

   Ages

   60 and older

   Site

   Rutgers, The State University of New Jersey - Newark campus, Newark, New Jersey

   Run by

   Rutgers, The State University of New Jersey

   See if you can join NCT05597124 on ClinicalTrials.gov

8. Amplitude Titration to Improve ECT Clinical Outcomes

   A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT: H1: Individualized amplitude arm…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of New Mexico Health Science Center, Albuquerque, New Mexico

   Run by

   University of New Mexico

   See if you can join NCT05699226 on ClinicalTrials.gov

9. Cognition After OSA Treatment Among Native American People (CATNAP)

   This research project will develop and implement a motivational interviewing and electronic messaging intervention to address obstructive sleep apnea (OSA), positive airway pressure (PAP) adherence, and risk of Alzheimer's disease and related dementias in American Indians. The project will work wit…

   Stage

   Not phased

   Ages

   40 and older

   Site

   Missouri Breaks Industries Research Inc, Eagle Butte, South Dakota

   Run by

   Washington State University

   See if you can join NCT06227572 on ClinicalTrials.gov

10. Executive Function Training for Children and Adolescents

    The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in adolescents with and without ADHD. The main questions it aims to answer are:…

    Stage

    Not phased

    Ages

    12 to 17

    Site

    Northeastern University, Boston, Massachusetts

    Run by

    Northeastern University

    See if you can join NCT07147894 on ClinicalTrials.gov

11. Moderators and Mediators of Perceptual Learning

    This is a research study about how training can impact performance on cognitive tasks. Participants are between 18 and 30 and 60 to 85 years of age, have normal (or corrected to normal) vision, and have no neurological conditions that would preclude their ability to complete computerized cognitive …

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of California, Riverside, California

    Locations

    3 in total

    Run by

    University of Wisconsin, Madison

    See if you can join NCT05894967 on ClinicalTrials.gov

12. Surviving Daily Life

    The primary goal of this project is to evaluate the feasibility of a 14-day mobile daily diary study among racially diverse breast cancer survivors. Further, the investigators will examine the validity and reliability of the daily stress and daily cognitive performance measures among breast cancer …

    Stage

    Not phased

    Ages

    40 and older

    Site

    Thomas Jefferson University, Philadelphia, Pennsylvania

    Run by

    Thomas Jefferson University

    See if you can join NCT07054723 on ClinicalTrials.gov

13. Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury

    The purpose of this study is to learn more about how brain stimulation affects word finding problems in people who have a traumatic brain injury (TBI). The type of brain stimulation used is called transcranial direct current stimulation (tDCS). tDCS delivers low levels of electric current to the br…

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Beth Israel Deaconess Medical Center, Boston, Massachusetts

    Run by

    Beth Israel Deaconess Medical Center

    See if you can join NCT06848140 on ClinicalTrials.gov

14. The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults

    Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acut…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    UNC Greensboro, Greensboro, North Carolina

    Run by

    University of North Carolina, Greensboro

    See if you can join NCT04861818 on ClinicalTrials.gov

15. Trout Consumption in Young Children and Families and Brain Health

    Regular fish consumption may support brain health. Trout lines developed in Idaho contain higher levels of omega-3 fatty acids, nutrients important for human cognition and mental wellbeing. Developed to support aquaculture sustainability, consumer preferences and human health benefits of these fish…

    Stage

    Not phased

    Ages

    3 and older

    Site

    University of Idaho, Moscow, Idaho

    Locations

    2 in total

    Run by

    University of Idaho

    See if you can join NCT06721468 on ClinicalTrials.gov

16. Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)

    The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults. Our research team will evaluate three different groups: …

    Stage

    Not phased

    Ages

    45 to 64

    Site

    University of Illinois at Urbana-Champaign, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT06605898 on ClinicalTrials.gov

17. Remote Evaluation of MIND Diet

    The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answ…

    Stage

    Not phased

    Ages

    18 to 64

    Site

    University of Illinois Urbana-Champaign, Urbana, Illinois

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT06450977 on ClinicalTrials.gov