Cigarette Smoking Clinical Trials

17 studies are recruiting for cigarette smoking in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Varenicline for Smoking Reduction in Veterans Not Ready To Quit

   In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt. Smoking treatments currently available to Veterans who are not ready to quit ar…

   Stage

   Phase 4

   Ages

   21 and older

   Site

   VA San Diego Healthcare System, San Diego, CA, San Diego, California

   Locations

   4 in total

   Run by

   VA Office of Research and Development

   See if you can join NCT06966362 on ClinicalTrials.gov

2. Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches

   Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free. The present study is evaluating how well nicotine pouches, at different nicotine levels, help people switch …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06678789 on ClinicalTrials.gov

3. A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

   This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications. Everyone who participates in this study will receive free product, either nicotine replacement therapies (patches and lozenges), varenicline, or a harm reduc…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06118502 on ClinicalTrials.gov

4. Switch or Quit R01

   This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline/Chantix). Participants in this study will be randomly assigned to one of two groups, then will have a choice …

   Stage

   Not phased

   Ages

   21 and older

   Site

   Medical Univeristy of South Carolina, Charleston, South Carolina

   Run by

   Medical University of South Carolina

   See if you can join NCT06373679 on ClinicalTrials.gov

5. Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

   This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national sample of people unmotivated to quit smoking. Participants will be ra…

   Stage

   Not phased

   Ages

   21 and older

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   Abramson Cancer Center at Penn Medicine

   See if you can join NCT07199517 on ClinicalTrials.gov

6. Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing

   This study will investigate the effects of normal-nicotine versus low-nicotine cigarette availability in the context of four tax proposals (Tobacco Parity, Nicotine-Content, Harm-Reduction, and Modified Risk Tobacco Product-based taxes) on tobacco product purchasing patterns in a virtual marketplac…

   Stage

   Not phased

   Ages

   21 and older

   Site

   Roswell Park Comprehensive Cancer Center, Buffalo, New York

   Locations

   2 in total

   Run by

   Virginia Polytechnic Institute and State University

   See if you can join NCT07142668 on ClinicalTrials.gov

7. Beta-Adrenergic Modulation of Drug Cue Reactivity

   This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking cues in ongoing cigarette smokers. This is a basic experimental study in …

   Stage

   Phase 4

   Ages

   21 to 60

   Site

   Hardesty Center for Clinical Research and Neuroscience, Tulsa, Oklahoma

   Run by

   University of Oklahoma

   See if you can join NCT05587361 on ClinicalTrials.gov

8. Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

   Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking. A mobile health (mHealth) intervention that translates effective smoking cessation materials and pharmacotherapy may be a…

   Stage

   Not phased

   Ages

   18 to 26

   Site

   University of Chicago BREATHE Laboratory, Chicago, Illinois

   Run by

   University of Chicago

   See if you can join NCT06395415 on ClinicalTrials.gov

9. RTMS Targets Neural Circuits for Smoking Cessation

   Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, i…

   Stage

   Not phased

   Ages

   22 to 70

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Locations

   2 in total

   Run by

   Medical University of South Carolina

   See if you can join NCT04903028 on ClinicalTrials.gov

10. Menthol, Inflammation, and Nicotine Transition Study

    This study will focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of cardiovascular disease risk.

    Stage

    Not phased

    Ages

    21 to 85

    Site

    Rosalind Franklin University of Medicine and Science, North Chicago, Illinois

    Run by

    Rosalind Franklin University of Medicine and Science

    See if you can join NCT06232447 on ClinicalTrials.gov

11. Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

    This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be inst…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06372899 on ClinicalTrials.gov

12. E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

    The purpose of this an open-label, randomized controlled trial study is to compare the effectiveness of electronic cigarettes (e-cigarettes/e-cigs) versus telehealth motivational counseling with combination nicotine replacement therapy (NRT) + telehealth counseling on combustible cigarettes smoking…

    Stage

    Phase 2

    Ages

    21 to 75

    Site

    NYU Langone Health, New York, New York

    Locations

    2 in total

    Run by

    NYU Langone Health

    See if you can join NCT05722561 on ClinicalTrials.gov

13. The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

    This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tob…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    Abramson Cancer Center at Penn Medicine

    See if you can join NCT06264154 on ClinicalTrials.gov

14. Semaglutide for Post-Smoking Cessation Weight Management

    This trial will examine the effect of semaglutide 2.4mg on changes in body weight, body composition, and peripheral and central mechanisms that control appetite, satiety, and food intake in the context of smoking cessation.

    Stage

    Phase 2

    Ages

    18 to 75

    Site

    The University of Texas at Austin, Austin, Texas

    Locations

    2 in total

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06173778 on ClinicalTrials.gov

15. Effect of Cannabis on Cigarette Use Behavior

    The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon mon…

    Stage

    Phase 1

    Ages

    21 and older

    Site

    Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06609083 on ClinicalTrials.gov

16. Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

    This study will investigate the effects of a very-low-nicotine cigarette (VLNC) standard, e-cigarette price, and illegal cigarette price on illegal product purchasing and alternative product use in a virtual marketplace.

    Stage

    Not phased

    Ages

    21 and older

    Site

    Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia

    Run by

    Virginia Polytechnic Institute and State University

    See if you can join NCT07161050 on ClinicalTrials.gov

17. E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

    In this open-label, randomized controlled trial study, participants who smoke combustible cigarettes (CC) and are diagnosed with Serious Mental Illness (SMI) will be randomized in two arms to receive harm-reduction counseling and Ecological Momentary Intervention text messaging (EMI) along with eit…

    Stage

    Not phased

    Ages

    21 and older

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT05815199 on ClinicalTrials.gov