Chronic Low-back Pain Clinical Trials

28 studies are recruiting for chronic low-back pain in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

   The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs). The ISAs may start independently of other ISAs as interventions become available for c…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Central Research Associates, Birmingham, Alabama

   Locations

   64 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT05986292 on ClinicalTrials.gov

2. Algorithm-informed Decision-making to Advance Pain Treatment

   Researchers are exploring how certain personal factors, such as symptoms, health history, and lifestyle, may help predict which treatments will work best for someone. The purpose of this study is to evaluate how well a study algorithm chooses the best treatments for a patient when considering their…

   Stage

   Not phased

   Ages

   25 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Run by

   University of Michigan

   See if you can join NCT07731750 on ClinicalTrials.gov

3. Psilocybin in Chronic Low Back Pain and Depression

   This study seeks to provide insight on psilocybin's effects on mechanisms of chronic pain among patients with co-morbid chronic low back pain and depression (CLBP+D). Participants will receive either a single high-dose of psilocybin (25mg absolute dose) or methylphenidate (40mg absolute dose). Part…

   Stage

   Phase 1

   Ages

   21 to 80

   Site

   Johns Hopkins University School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT06355414 on ClinicalTrials.gov

4. Intracept Minimally-invasive PROcedure for VErtebrogenic Back Pain

   Compile real-world outcomes of commercially approved Intracept™ Intraosseous Nerve Ablation Systems in the treatment of patients diagnosed with vertebrogenic pain.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Flagstaff Bone & Joint, Flagstaff, Arizona

   Locations

   21 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT06827262 on ClinicalTrials.gov

5. Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control

   Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU). In addition, to compile real-world clinical outcomes in subjects with chronic, intractable low back and/o…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Denver Back Pain Specialists, Greenwood, Colorado

   Locations

   7 in total

   Run by

   Boston Scientific Corporation

   See if you can join NCT07190807 on ClinicalTrials.gov

6. Telerehabilitation for Patients With Chronic Low Back Pain (TeleBACK Clinical Trial)

   The investigators will conduct a prospective, randomized, clinical trial addressing key questions to understanding the effectiveness of telerehabilitation (physical therapy delivered via video-visits) and in-clinic physical therapy for patients with chronic low back pain (LBP). The investigators al…

   Stage

   Not phased

   Ages

   18 to 64

   Site

   Johns Hopkins University School of Medicine, Baltimore, Maryland

   Locations

   3 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06821607 on ClinicalTrials.gov

7. Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

   To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Yale New Haven Health Old Saybrook Medical Center, Old Saybrook, Connecticut

   Run by

   Yale University

   See if you can join NCT07639060 on ClinicalTrials.gov

8. Improving Health for Patients With Chronic Low Back Pain in Rural Communities Through Telerehabilitation

   Physical therapy is the first line of treatment for patients with low back pain (LBP) and has been shown to be a cost-effective method for improving pain and disability in patients with chronic LBP; however, despite this effectiveness, only 7-13% of patients go on to receive physical therapy servic…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins University School of Medicine, Baltimore, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT06471920 on ClinicalTrials.gov

9. Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

   This study will identify unique signatures that people have which can cause pain by evaluating biological, psychological, and social markers using artificial intelligence. These markers can be used to accurately predict the response of diverse individuals with chronic low back pain (cLBP) to Mindfu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Boston Medical Center, Boston, Massachusetts

   Run by

   Boston Medical Center

   See if you can join NCT06106191 on ClinicalTrials.gov

10. Clinician Satisfaction With the VERABAND™

    The VERABAND™ is a newly-developed, disposable, wearable activity monitor. The researchers will assess clinician satisfaction with the usability and likelihood of clinical adoption of the newly-developed, disposable, wearable activity monitor, across multiple clinical sites in the chronic low back …

    Stage

    Not phased

    Ages

    18 to 85

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Locations

    3 in total

    Run by

    University of Michigan

    See if you can join NCT06080464 on ClinicalTrials.gov

11. Detection of EEG-Based Biomarkers of Chronic Low Back Pain

    Chronic low back pain (CLBP) is a pervasive disorder affecting up to one-fifth of adults globally and is the single greatest cause of disability worldwide. Despite the high prevalence and detrimental impact of CLBP, its treatments and mechanisms remain largely unclear. Biomarkers that predict sympt…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford's Systems and Neuroscience Pain Lab, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06025201 on ClinicalTrials.gov

12. Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response

    VETERANS ONLY. Chronic low back pain (cLBP) is common. Most Americans will have at least one episode of low back pain in their lifetimes. Approximately 50% of all US Veterans have chronic pain, and CLBP is the most common type of pain in this population. This study will use a sequential randomized,…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

    Locations

    19 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT04142177 on ClinicalTrials.gov

13. MBM and taVNS for Low Back Pain and Depressive Symptoms

    This two-arm randomized controlled trial aims to test the preliminary effect of home-based mindfulness-based meditation and transcutaneous auricular vagus nerve stimulation on managing pain and depressive symptoms among community-dwelling older adults with chronic low back pain and depressive sympt…

    Stage

    Not phased

    Ages

    50 to 85

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT07415941 on ClinicalTrials.gov

14. Modulation Effect of tACS on Chronic Low Back Pain

    Investigating the modulation effect of tACS

    Stage

    Phase 2

    Ages

    18 to 60

    Site

    Massachusetts General Hospital, Charlestown, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06568198 on ClinicalTrials.gov

15. Physical Exam, Static & Dynamic Ultrasound Assessment, & Treatment of Thoracolumbar Fascia (TLF) Mediated Low Back Pain

    This Study is for our continued study of the Thoracolumbar Fascia (TFL) in patients with and without low back pain by our experienced multidisciplinary team: Vincent Wang PhD, VT Biomedical Engineering \& Mechanics (BEAM). Albert J Kozar DO, FAOASM, R-MSK. P. Gunnar Brolinson, DO, FAOASM, FAOCFP. D…

    Stage

    Not phased

    Ages

    18 to 50

    Site

    Edward Via College of Osteopathic Medicine, Blacksburg, Virginia

    Run by

    Edward Via Virginia College of Osteopathic Medicine

    See if you can join NCT06818175 on ClinicalTrials.gov

16. Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain

    As a leading cause of disability worldwide, chronic low back pain (cLBP) represents a significant medical and socioeconomic problem with estimated health care spending of $87 billion/annually. The efficacy of dorsal column electrical stimulation to inhibit pain was first described over 50 years ago…

    Stage

    Not phased

    Ages

    21 to 85

    Site

    San Francisco VA Medical Center, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05265000 on ClinicalTrials.gov

17. AuriculoTherapy NeuroImaging

    This is a clinical study of patients who have low back pain (for at least 6 months). The goal is to understand, with brain imaging, how auriculotherapy (an acupuncture-like stimulation of the ear) may work to relieve pain. There are 4 total study visits, divided into two pairs of visits that occur …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Keith M Vogt

    See if you can join NCT06825390 on ClinicalTrials.gov

18. Phenotyping Response to Spinal Cord Stimulation in Chronic Low Back Pain

    Chronic low back pain (CLBP) is a debilitating condition and costly to treat. Long-term drug treatment often fails due to habituation, breakthrough of pain, or adverse effects of drug treatment. Opioid use to manage this pain has contributed to the opioid epidemic. Spinal cord stimulators have emer…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of California, Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT06310226 on ClinicalTrials.gov

19. Active Music-Based Intervention in Patients With Chronic Low Back Pain

    The goal of this clinical trial is to learn if active music-based intervention works to treat patients with chronic low back pain. The main questions it aims to answer are: 1. Does active music-based intervention improve cognitive function? 2. Does active music -based intervention improve sensitivi…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Texas Woman's University, Department of Music, Denton, Texas

    Run by

    Sharon Wang-Price

    See if you can join NCT06940063 on ClinicalTrials.gov

20. Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression

    This is a pilot study to evaluate the feasibility, acceptability, and safety of ketamine infusions followed by a brief behavioral intervention in Veterans with chronic low back pain and depression.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor, Michigan

    Run by

    VA Office of Research and Development

    See if you can join NCT06419439 on ClinicalTrials.gov

21. Mobile Neurofeedback for Low Back Pain

    The purpose of this study is to learn more about improving the quality of treatments for people who have chronic low back pain. Participants will complete interviews with Duke researchers at four different time points: the beginning of the study, at 3 months, at 6 months, and at 9 months. Participa…

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Duke University Medical Center, Department of Psychiatry, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT05669027 on ClinicalTrials.gov

22. Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management.

    The purpose of this study is to better understand how people feel after a radiofrequency ablation standard of care surgery using a different type of needle (multi-tined expandable electrode/MEE) in comparison to receiving conventional medical management (CMM) techniques.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Kansas Medical Center, Kansas City, Kansas

    Run by

    University of Kansas Medical Center

    See if you can join NCT04730700 on ClinicalTrials.gov

23. Meditation for Older Adults With Chronic Low Back Pain

    This pilot randomized controlled trial aims to recruit 66 community-dwelling older adults with chronic low back pain and follow up them for 8 weeks. This study aims to test the preliminary effect of a mindfulness-based meditation (MBM) intervention on pain and symptoms among community-dwelling olde…

    Stage

    Not phased

    Ages

    50 to 89

    Site

    Florida State University, Tallahassee, Florida

    Run by

    Florida State University

    See if you can join NCT06384001 on ClinicalTrials.gov

24. Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain

    In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the partic…

    Stage

    Not phased

    Ages

    21 and older

    Site

    University of California Los Angeles, Los Angeles, California

    Run by

    University of California, Los Angeles

    See if you can join NCT04658628 on ClinicalTrials.gov

25. Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA

    This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT05754190 on ClinicalTrials.gov