Chronic Kidney Diseases Clinical Trials

38 studies are recruiting for chronic kidney diseases in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Improving the Collaborative Health of Adult Dyads

   This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and people from rural regions are more likely burdened with greater …

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of South Carolina, Columbia, South Carolina

   Run by

   University of South Carolina

   See if you can join NCT05370014 on ClinicalTrials.gov

2. Partners Calciphylaxis Biobank

   Calciphylaxis, a vascular calcification disorder, is a rare and serious disorder characterized by calcification of dermal arterioles. There are significant gaps in the understanding of the pathophysiology and risk factors for calciphylaxis. At present, there is no effective treatment. Uncertain pat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT03032835 on ClinicalTrials.gov

3. Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

   The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.

   Stage

   Not phased

   Ages

   55 and older

   Site

   Georgetown University, Washington D.C., District of Columbia

   Locations

   2 in total

   Run by

   Columbia University

   See if you can join NCT05655325 on ClinicalTrials.gov

4. A Long-Term Follow-Up Study of Participants Exposed to REACT

   The purpose of this study is to evaluate the long-term safety of up to two gelatin-hydrogel formulation REACT injections given 3 to 6 months apart and delivered percutaneously into same kidney on renal function in participants with chronic kidney disease (CKD).

   Stage

   Not phased

   Ages

   30 to 80

   Site

   Boise Kidney & Hypertension Institute, Meridian, Idaho

   Run by

   Prokidney

   See if you can join NCT05918523 on ClinicalTrials.gov

5. Enhancing Physical Function in Older Adults With Chronic Kidney Disease

   The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the eff…

   Stage

   Not phased

   Ages

   65 to 100

   Site

   Wake Forest University Health Sciences, Winston-Salem, North Carolina

   Run by

   Wake Forest University Health Sciences

   See if you can join NCT06738394 on ClinicalTrials.gov

6. Effect of Empagliflozin on Podocyte Specific Proteins in African American Veterans With NDKD

   Primary Objective: To study podocyte specific injury markers in African American Veterans with non-diabetic kidney disease (NDKD), on empagliflozin therapy. Primary Endpoint: We will assess the effect of Empagliflozin on podocyte-specific proteins in exosomes isolated from subjects' urine, such as …

   Stage

   Phase 4

   Ages

   19 to 90

   Site

   Washington DC Veterans Affairs Medical Center (688), Washington D.C., District of Columbia

   Run by

   Washington D.C. Veterans Affairs Medical Center

   See if you can join NCT06110130 on ClinicalTrials.gov

7. Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease

   The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin) helps improve risk factors for worsening kidney …

   Stage

   EARLY_Phase 1

   Ages

   12 to 25

   Site

   Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

   Run by

   Ann & Robert H Lurie Children's Hospital of Chicago

   See if you can join NCT06430684 on ClinicalTrials.gov

8. Real World Evidence Clinical Utility Study of KidneyIntelX

   The purpose of this study is to assess the impact of the KidneyIntelX assay utilized as part of the current standard of care on the management of patients seen in the primary care physician's office at Mount Sinai.

   Stage

   Not phased

   Ages

   23 and older

   Site

   Mount Sinai Health System, New York, New York

   Run by

   Renalytix AI, Inc.

   See if you can join NCT04802395 on ClinicalTrials.gov

9. Sit Less, Interact and Move More (SLIMM) 2 Study

   * Prolonged sitting (sedentary behavior) is a risk factor for decreased kidney function, obesity, diabetes and mortality. Prolonged sitting is associated with decreased kidney function and increased risk of diabetes, heart disease and death. * In a previous pilot study funded by NIH, it was shown t…

   Stage

   Phase 2

   Ages

   20 and older

   Site

   Stanford University, Stanford, California

   Locations

   2 in total

   Run by

   Srinvasan Beddhu

   See if you can join NCT05173714 on ClinicalTrials.gov

10. NAVIGATE Kidney: A Multi-level Intervention to Reduce Kidney Health Disparities

    The overarching goal of this project is to refine and adapt previous work on the NAVIGATE-Kidney project for individuals with CKD. The investigators hypothesize that the multilevel NAVIGATE-Kidney program intervention will reduce the rate of central venous catheter use at KRT start (primary outcome…

    Stage

    Not phased

    Ages

    18 to 75

    Site

    Denver Health and Hospital Authority, Denver, Colorado

    Locations

    2 in total

    Run by

    University of Colorado, Denver

    See if you can join NCT06810622 on ClinicalTrials.gov

11. Care Transitions App for Patients With Multiple Chronic Conditions

    The objective of this study is to widely implement and evaluate the Care Transitions App in a randomized controlled trial. The app the investigators designed for patients with multiple chronic conditions has four envisioned modules: 1) falls-reduction content, 2) a digital post-discharge transition…

    Stage

    Not phased

    Ages

    55 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Run by

    Brigham and Women's Hospital

    See if you can join NCT06051058 on ClinicalTrials.gov

12. SPYRAL GEMINI Pilot Study

    The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with and without high cardiovascular risk.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Stanford Hospital and Clinics, Stanford, California

    Locations

    18 in total

    Run by

    Medtronic Vascular

    See if you can join NCT06907147 on ClinicalTrials.gov

13. Precision Medicine Approaches to Renal Osteodystrophy

    Treatment of renal osteodystrophy is impeded by the lack of practical and accurate tools to determine underlying bone turnover. Gold standard bone biopsy is not practical in the clinic for the vast majority of kidney disease patients and parathyroid hormone and bone alkaline phosphatase have insuff…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Washington University in St. Louis (WashU), St Louis, Missouri

    Run by

    Thomas Nickolas

    See if you can join NCT05880914 on ClinicalTrials.gov

14. American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)

    Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key risk factors for these diseases remain unanswered in the AI population. …

    Stage

    Not phased

    Ages

    21 to 80

    Site

    First Nations Community Health Source, Albuquerque, New Mexico

    Locations

    3 in total

    Run by

    University of New Mexico

    See if you can join NCT04185844 on ClinicalTrials.gov

15. Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

    Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vi…

    Stage

    Phase 2

    Ages

    21 to 85

    Site

    University of California Davis Health, Sacramento, California

    Locations

    2 in total

    Run by

    University of California, Davis

    See if you can join NCT04984226 on ClinicalTrials.gov

16. Chronic Kidney Disease-Education (CKD-EDU)

    The investigators are conducting a study to see which program better helps older patients with kidney disease choose their treatment. Investigators are also investigating if either program can reduce the number of hospital or emergency room visits in the first 6 months of the study, as well as pote…

    Stage

    Not phased

    Ages

    75 and older

    Site

    UR Medicine Nephrology - Strong West, Brockport, New York

    Locations

    5 in total

    Run by

    University of Rochester

    See if you can join NCT06410144 on ClinicalTrials.gov

17. Mixed Methods Study of Health-Related Social Needs in African American Adults With Chronic Kidney Disease and Type 2 Diabetes Mellitus

    The overarching goal of this study is to understand facilitators and barriers to self-care, develop and refine a culturally tailored intervention to improve clinical outcomes, quality of life (QOL), and self-care behaviors in African American adults with diabetic kidney disease (DKD) experiencing h…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05692388 on ClinicalTrials.gov

18. Concomitant Renal and Urinary Bladder Allograft Transplantation

    The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.

    Stage

    EARLY_Phase 1

    Ages

    1 to 60

    Site

    Mayo Clinic, Rochester, Minnesota

    Locations

    2 in total

    Run by

    Mayo Clinic

    See if you can join NCT04626167 on ClinicalTrials.gov

19. Ferric Citrate and Chronic Kidney Disease in Children

    We will conduct a 12-month, double-blind, randomized, placebo-controlled trial to assess the effects of therapy with ferric citrate (FC) on changes in intact FGF23 levels (iFGF23, primary endpoint) in 160 pediatric patients (80 in each of the two arms) aged 6-18 years of either sex with chronic kid…

    Stage

    Phase 2

    Ages

    6 to 18

    Site

    University of California, Los Angeles, Los Angeles, California

    Locations

    20 in total

    Run by

    University of California, Los Angeles

    See if you can join NCT04741646 on ClinicalTrials.gov

20. Kidney Precision Medicine Project

    Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and …

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Arizona, Tucson, Arizona

    Locations

    13 in total

    Run by

    Icahn School of Medicine at Mount Sinai

    See if you can join NCT04334707 on ClinicalTrials.gov

21. Home Hospital for Suddenly Ill Adults

    The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be delivered in the home with equal quality and safety, reduced cost, and impro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Brigham and Women's Hospital, Boston, Massachusetts

    Locations

    2 in total

    Run by

    Brigham and Women's Hospital

    See if you can join NCT03524222 on ClinicalTrials.gov

22. BLOOM: Biological Legacy of Origin in Mother-Infant Dyads

    Infants born preterm and of low birth weight are known to be at increased risk for early onset of cardiovascular and renal disease in adult life. This has been related to low nephron mass due to inadequate or early termination of glomerulogenesis in utero and during the perinatal period. Risks for …

    Stage

    Not phased

    Ages

    Up to 10

    Site

    University of Miami/ Holtz Children's Hospital, Miami, Florida

    Run by

    University of Miami

    See if you can join NCT02000895 on ClinicalTrials.gov

23. SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

    This is a prospective, randomized, multi-center clinical trial for chronic kidney disease (CKD) patients referred for creation of a new arteriovenous fistula (AVF) in order to assess the safety and effectiveness of SelfWrap, a bioabsorbable perivascular wrap.

    Stage

    Not phased

    Ages

    18 and older

    Site

    AKDHC Bullhead City, Bullhead City, Arizona

    Locations

    28 in total

    Run by

    VenoStent

    See if you can join NCT06001827 on ClinicalTrials.gov

24. Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

    Socioeconomically disadvantaged populations with multiple chronic conditions have high rates of nonadherence to essential chronic disease medications after hospital discharge. Medication nonadherence after hospital discharge is significantly associated with increased mortality and higher rates of r…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Tennessee Health Science Center/Regional One Health, Memphis, Tennessee

    Locations

    2 in total

    Run by

    University of Tennessee

    See if you can join NCT06374277 on ClinicalTrials.gov

25. Safety and Tolerability of Vertebral Bone Marrow-derived Mesenchymal Stem Cells (BM-MSC) in Real World Scenarios of Patients With Chronic Kidney Disease (CKD)

    The purpose of this protocol is to treat an intermediate-sized population with chronic kidney disease (CKD) including kidney transplant recipients. The protocol uses allogeneic bone marrow-derived mesenchymal stem cells (MSCs). MSC infusion may be delivered 1) intravenous or 2) intravenous plus int…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Jacksonville, Florida

    Run by

    Mayo Clinic

    See if you can join NCT06752577 on ClinicalTrials.gov