Chronic Kidney Disease Clinical Trials

35 studies are recruiting for chronic kidney disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria

   Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children wit…

   Stage

   Phase 3

   Ages

   1 to 18

   Site

   Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department, Buenos Aires,

   Locations

   151 in total

   Run by

   Bayer

   See if you can join NCT05457283 on ClinicalTrials.gov

2. A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

   This study is open to children aged 2 to 17 with chronic kidney disease (CKD). The purpose of this study is to find out if a medicine called empagliflozin helps children and adolescents with CKD. Other goals of the study are to find out how empagliflozin is tolerated and handled by the body in chil…

   Stage

   Phase 3

   Ages

   2 to 17

   Site

   Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

   Locations

   93 in total

   Run by

   Boehringer Ingelheim

   See if you can join NCT07107945 on ClinicalTrials.gov

3. A Natural History Study of Metabolic Sizing in Health and Disease

   Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate. But metabolism varies among people with similar body sizes. Scientists now believe the old formulas for estim…

   Stage

   Not phased

   Ages

   2 to 99

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT05398783 on ClinicalTrials.gov

4. Feasibility of The Health Integrated Nutrition and Kidney Wellness Program

   Purpose of the Study: This clinical trial will test whether a nutrition and kidney health program can work well for adults with kidney disease. The program was created with help from patients and community partners. Main Questions: How many eligible patients choose to join the program? How many par…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC Kidney Clinic - Wexford, Pittsburgh, Pennsylvania

   Locations

   5 in total

   Run by

   University of Pittsburgh

   See if you can join NCT07518719 on ClinicalTrials.gov

5. A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.

   This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled multicenter study to investigate outcomes with elecoglipron compared with placebo in participants with CKD with and without T2DM who are on background SGLT2i (dapagliflozin) as GDMT and other SoC treatments for CKD.

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Research Site, Minneapolis, Minnesota

   Locations

   715 in total

   Run by

   AstraZeneca

   See if you can join NCT07753993 on ClinicalTrials.gov

6. Pivotal Study of the Velocity™ pAVF System

   This study will evaluate the Velocity Percutaneous Arteriovenous Fistula (pAVF) System, a new minimally invasive method for creating dialysis access. People with kidney failure often require dialysis, which depends on having a reliable arteriovenous fistula (AVF). Traditionally, AVFs are created wi…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Trinity Research Group, Dothan, Alabama

   Locations

   13 in total

   Run by

   Venova Medical

   See if you can join NCT07153939 on ClinicalTrials.gov

7. Breakthrough - T1DM and Chronic Kidney Disease

   Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: * An investigational drug called Tegoprubart and * Human pancreatic islet cells Both Te…

   Stage

   Phase 1

   Ages

   18 to 70

   Site

   Diabetes Research Institute, University of Miami, Miami, Florida

   Locations

   2 in total

   Run by

   University of Chicago

   See if you can join NCT07592000 on ClinicalTrials.gov

8. Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease

   The purpose of this first-in-human (FIH) study is to evaluate safety, tolerability, pharmacokinetic (PK) of OJR520.

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Quotient Sciences Sea View, Miami, Florida

   Locations

   2 in total

   Run by

   Novartis Pharmaceuticals

   See if you can join NCT07235059 on ClinicalTrials.gov

9. A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort

   This study will evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses (SAD) and multiple ascending doses (MAD) of AZD4248 administered as an oral solution and intravenous (IV) infusion. Additionally, the study investigates the non-interventional f…

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   Research Site, Glendale, California

   Locations

   5 in total

   Run by

   AstraZeneca

   See if you can join NCT07024823 on ClinicalTrials.gov

10. Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

    The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06877169 on ClinicalTrials.gov

11. A Study of Luspatercept in People With Anemia

    The researchers are doing this study to test whether luspatercept works to improve hemoglobin levels in people with anemia caused by chronic kidney disease (CKD). The researchers will also test whether luspatercept is a safe treatment that causes few or mild side effects in participants.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey

    Locations

    7 in total

    Run by

    Memorial Sloan Kettering Cancer Center

    See if you can join NCT07725497 on ClinicalTrials.gov

12. Renal Impairment Study for Oral EC5026

    The goal of this Phase 1 clinical trial is to assess single dose pharmacokinetics of oral EC5026 in a population with chronic kidney disease. The main questions it aims to answer are: 1. To determine if the PK of a single 8 mg dose of EC5026, administered orally, in adult participants with varying …

    Stage

    Phase 1

    Ages

    55 and older

    Site

    UC Davis Medical Center, Sacramento, California

    Run by

    EicOsis Human Health Inc.

    See if you can join NCT07694544 on ClinicalTrials.gov

13. An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions

    This is an observational study, in which data from people in Asia and in the United States with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied. The participants in this study are already receiving the study treatment finerenone as part of their regular care from their …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Bayer, Berlin,

    Locations

    4 in total

    Run by

    Bayer

    See if you can join NCT06278207 on ClinicalTrials.gov

14. Adia Med of Winter Park LLC Chronic Kidney Disease Research Study

    The goal of this clinical trial is to learn whether a new regenerative treatment called AdiaVita, made from umbilical cord blood-derived stem cells and exosomes combined with glutathione, is safe and can help improve kidney function in adults with chronic kidney disease (CKD). In this condition, th…

    Stage

    Phase 1

    Ages

    18 to 80

    Site

    Adia Med Of Winter Park, Winter Park, Florida

    Run by

    Adia Med of Winter Park LLC

    See if you can join NCT07572890 on ClinicalTrials.gov

15. Safety of Short-course of NSAIDs in Pediatric Patients With CKD

    The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased ri…

    Stage

    Phase 4

    Ages

    1 to 25

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06860711 on ClinicalTrials.gov

16. Proteogenomic Monitoring and Assessment of Liver Transplant Recipients

    This study is being done to test blood, urine and tissue samples to see if this can help decide if CKD (Chronic Kidney Disease), AR (Acute Rejection) and HCV (Hepatitis C Virus) can be identified in its early stages. CKD damage to the kidneys, AR and HCV all lower the body's ability to function pro…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Northwestern Memorial Hospital, Chicago, Illinois

    Run by

    Northwestern University

    See if you can join NCT01644903 on ClinicalTrials.gov

17. Sympatholysis in Chronic Kidney Disease

    The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

    Stage

    Phase 1

    Ages

    18 to 75

    Site

    Atlanta VA Medical Center, Decatur, Georgia

    Run by

    Emory University

    See if you can join NCT02411773 on ClinicalTrials.gov

18. Empagliflozin Treatment in Kidney Transplant Recipients

    Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continue to be challenging. Patient death with existing kidney graft function occurs in about half of all …

    Stage

    Phase 4

    Ages

    19 and older

    Site

    Edward Hines Jr. VA Hospital, Hines, IL, Hines, Illinois

    Locations

    5 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06013865 on ClinicalTrials.gov

19. Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)

    The Division of Kidney, Urologic, and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in collaboration with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung and Bloo…

    Stage

    Not phased

    Ages

    0 to 22

    Site

    Children's Mercy Kansas City, Kansas City, Missouri

    Locations

    2 in total

    Run by

    Johns Hopkins Bloomberg School of Public Health

    See if you can join NCT00327860 on ClinicalTrials.gov

20. Sickle Cell Kidney Biorepository

    Kidney disease is a major cause of illness and death in people with sickle cell disease and sickle cell trait. Despite these concerning facts, we do not (1) have an in-depth understanding of how kidney disease starts in sickle cell disease and sickle cell trait, (2) have detailed insights into why …

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Parkland Memorial Hospital, Dallas, Texas

    Locations

    2 in total

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT07064174 on ClinicalTrials.gov

21. Transforming Hemodialysis-Related Vascular Access Education

    The focus of this study is on vascular access for hemodialysis. This is a randomized clinical trial testing 3 educational approaches to help patients with advanced chronic kidney disease prepare for placement of hemodialysis vascular access. Study participants will each be assigned to one of the 3 …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Johns Hopkins University, Baltimore, Maryland

    Locations

    3 in total

    Run by

    University of Pennsylvania

    See if you can join NCT05997875 on ClinicalTrials.gov

22. A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

    The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes, living with overweight or obesity. The participants will either get N…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Naka Kinen Clinic_Internal medicine, Ibaraki,

    Locations

    147 in total

    Run by

    Novo Nordisk A/S

    See if you can join NCT06717698 on ClinicalTrials.gov

23. Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

    The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding. It can also cause symptoms such as abdominal pain and nausea. By participating in this stu…

    Stage

    Not phased

    Ages

    19 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT06306963 on ClinicalTrials.gov

24. A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

    This is a phase 3 trial of etelcalcetide in pediatric participants with secondary hyperparathyroidism (SHPT) and chronic kidney disease (CKD) on hemodialysis.

    Stage

    Phase 3

    Ages

    0 to 18

    Site

    Childrens Hospital of Los Angeles, Los Angeles, California

    Locations

    43 in total

    Run by

    Amgen

    See if you can join NCT03633708 on ClinicalTrials.gov

25. A Stakeholder-enhanced Intervention to Improve the Decisional Partnership of Chronic Kidney Disease Dyads (IMPART)

    Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this study is to pilot test, an optimization trial approach to develop and refine the decision partnering skills of persons with stage 4 chronic kidney disease and their caregivers. Using a 2x2x2 full…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Shena Gazaway, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06173323 on ClinicalTrials.gov