Cataract Clinical Trials

20 studies are recruiting for cataract in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Clareon TruPlus vs Tecnis Eyhance IOLs in Cataract Patients

   This study is a prospective, randomized, two-arm, single-center, single-surgeon, double-masked (subject and assessor) comparative study. It involves bilateral implantation of intraocular lenses (IOLs), comparing Clareon TruPlus IOL and Tecnis Eyhance IOLs in normal cataract patients. The study will…

   Stage

   Not phased

   Ages

   18 and older

   Site

   North Georgia Eye Associates, Gainesville, Georgia

   Run by

   Gainesville Eye Associates

   See if you can join NCT07658040 on ClinicalTrials.gov

2. Lacrifill for Ocular Surface Optimization in Cataract Surgery

   This is a single-site observational study designed to evaluate the efficacy of Lacrifill™ canalicular filler in optimizing ocular surface parameters and biometric precision in prospective cataract surgery patients with dry eye disease (DED).

   Stage

   Not phased

   Ages

   40 and older

   Site

   The Eye Institute of West Florida, Largo, Florida

   Run by

   The Eye Institute of West Florida

   See if you can join NCT07648095 on ClinicalTrials.gov

3. Post-refractive IOL Outcomes With Clareon TruPlus

   This is a prospective, single-arm, single-center, single-surgeon study evaluating the Clareon TruPlus IOL in post-refractive cataract patients. Subjects will be assessed up to 3 months post-operatively. Clinical evaluations will include refractive outcomes, visual acuity, and administration of the …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Physicians Protocol, Greensboro, North Carolina

   Run by

   Laser Defined Vision

   See if you can join NCT07610226 on ClinicalTrials.gov

4. Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery

   This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain neuroscience education, guided imagery, and paced breathing, reduces intraopera…

   Stage

   Not phased

   Ages

   Any age

   Site

   Stein Eye Institute - University of California Los Angeles, Los Angeles, California

   Run by

   University of California, Los Angeles

   See if you can join NCT07715591 on ClinicalTrials.gov

5. A Prospective, Randomized, Subject- and Examiner-Masked, Multicenter Study Comparing Bilateral Clareon TruPlus and Bilateral Clareon Monofocal Intraocular Lens Implantation (Spherical and Toric) in Cataract Subjects

   This investigator-initiated trial is a prospective, randomized, parallel-group, bilateral implantation study comparing Clareon TruPlus versus Clareon monofocal intraocular lenses (IOLs). Spherical and toric models are permitted in both arms based on standardized preoperative planning and clinical i…

   Stage

   Phase 4

   Ages

   22 and older

   Site

   Berkeley Eye Center - Sugar Land, Sugar Land, Texas

   Run by

   Berkeley Eye Center

   See if you can join NCT07693205 on ClinicalTrials.gov

6. Visual and Patient Reported Outcomes With Clareon TruPlus

   This is a prospective, single-site, two-surgeon, single-arm, observational study evaluating the Clareon TruPlus IOL. Subjects will be assessed up to 3 months post-operatively. Clinical evaluations will include refractive outcomes, visual acuity, and administration of the IOLSAT Questionnaire.

   Stage

   Not phased

   Ages

   18 and older

   Site

   Ovo Lasik + Lens, Saint Louis Park, Minnesota

   Run by

   OVO LASIK + Lens

   See if you can join NCT07648355 on ClinicalTrials.gov

7. To Study Ocular Outflow Dynamics of the Eye Using Intraoperative Tonographic Biometry and Assess Its Predictive Value in Improving Postoperative Outcomes.

   The objective of this study is to evaluate ocular outflow dynamics of the eye using intraoperative tonographic biometry and assess its predictive value in improving postoperative outcomes.

   Stage

   Not phased

   Ages

   18 and older

   Site

   New York Eye and Ear Infirmary of Mount Sinai, New York, New York

   Run by

   The New York Eye & Ear Infirmary

   See if you can join NCT07425496 on ClinicalTrials.gov

8. IC-8 Apthera IOL New Enrollment Post Approval Study

   The purpose of this study is to verify the post-market safety of the IC-8 Apthera IOL after the treatment of posterior capsular opacification (PCO), an expected complication related to IC-8 Apthera IOL implantation.

   Stage

   Not phased

   Ages

   22 and older

   Site

   Trinity Research Group, LLC, Dothan, Alabama

   Locations

   14 in total

   Run by

   Bausch & Lomb Incorporated

   See if you can join NCT06060041 on ClinicalTrials.gov

9. Outcomes of Clareon PanOptix Pro in Patients With Prior Myopic Refractive Surgery

   This study is a Single center, single arm, prospective, observational study of clinical outcomes following bilateral cataract surgery and Clareon PanOptix Pro implantation. Subjects will be assessed preoperatively, and at 1 and 3 months postoperatively. Clinical evaluations will include administrat…

   Stage

   Not phased

   Ages

   45 and older

   Site

   Juliette Eye Institute Research Center, Albuquerque, New Mexico

   Run by

   Juliette Eye Institute Research Center

   See if you can join NCT06555289 on ClinicalTrials.gov

10. Odyssey Evaluation in Post LASIK Patients

    This prospective study evaluates the visual and refractive outcomes of the TECNIS Odyssey intraocular lens (IOL) implanted in patients with a history of myopic LASIK. Given the unique optical challenges of post-LASIK eyes, including altered corneal curvature and higher-order aberrations, the study …

    Stage

    Phase 4

    Ages

    50 and older

    Site

    Center For Sight, Venice, Florida

    Run by

    Center For Sight

    See if you can join NCT07260695 on ClinicalTrials.gov

11. Unity VCS: A Comparison Study Evaluating Corneal Clarity and Thickness

    Phacoemulsification (cataract surgery) is usually performed while temporarily increasing the pressure inside the eye. The purpose of this study is to see if maintaining different pressure levels inside the eye during this procedure results in fewer side effects and better vision shortly after the s…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Metrolina Eye Associates, Matthews, North Carolina

    Run by

    Metrolina Eye Associates, PLLC

    See if you can join NCT07222150 on ClinicalTrials.gov

12. Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)

    This trial is a randomized study to evaluate the Bimatoprost Implant System used in combination with the SpyGlass IOL to Timolol Ophthalmic Solution in participants with mild to moderate open-angle glaucoma or ocular hypertension undergoing cataract surgery.

    Stage

    Phase 3

    Ages

    22 and older

    Site

    Houston Eye Associates, Houston, Texas

    Run by

    SpyGlass Pharma, Inc.

    See if you can join NCT07218783 on ClinicalTrials.gov

13. Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)

    This trial is a randomized study to evaluate the Bimatoprost Implant System used in combination with the SpyGlass IOL to Timolol Ophthalmic Solution in participants with mild to moderate open-angle glaucoma or ocular hypertension undergoing cataract surgery.

    Stage

    Phase 3

    Ages

    22 and older

    Site

    R and R Eye Research, LLC, San Antonio, Texas

    Run by

    SpyGlass Pharma, Inc.

    See if you can join NCT07218796 on ClinicalTrials.gov

14. Effective Phaco Time and Endothelial Cell Loss When Using Veritas

    This study is a single center, prospective study of cumulative dissipated energy and endothelial cells loss per phacoemulsification procedure after successful cataract surgery. Subjects will be assessed 3 months postoperatively at a single visit. Clinical evaluations will include central corneal th…

    Stage

    Not phased

    Ages

    Any age

    Site

    Aloha Vision Consultants, ‘Aiea, Hawaii

    Run by

    Aloha Vision Consultants

    See if you can join NCT07176416 on ClinicalTrials.gov

15. Intraoperative OCT Guidance of Intraocular Surgery II

    The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes. The investigators believe this technology will enable novel ophthalmic and other mi…

    Stage

    Not phased

    Ages

    0 and older

    Site

    Duke University Eye Center, Durham, North Carolina

    Run by

    Duke University

    See if you can join NCT03713268 on ClinicalTrials.gov

16. Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

    The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the development of postoperative complications. The investigators propose to repla…

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT05157113 on ClinicalTrials.gov

17. A Prospective, Randomized, Subject and Vision-assessor Masked, Multicenter Study Comparing Bilateral Clareon PanOptix, Bilateral Clareon PanOptix Pro, and Mixed Clareon PanOptix Pro/Vivity Intraocular Lens Implantation in Cataract Subjects

    Prospective, randomized, multicenter, multi-arm, subject and vision-assessor-masked, two stage study with Stage 1 as a three-arm initial enrollment period, followed by Stage 2 as a head-to-head study refined based on the Stage 1 data.

    Stage

    Phase 4

    Ages

    40 and older

    Site

    Shafer Vision Institute, Plymouth Meeting, Pennsylvania

    Locations

    2 in total

    Run by

    Berkeley Eye Center

    See if you can join NCT06922084 on ClinicalTrials.gov

18. Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract

    A Phase 3/4, Prospective, Randomized, Active Treatment-Controlled, Parallel-Design, Multicenter Study to Evaluate the Safety of DEXYCUfor the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract

    Stage

    Phase 4

    Ages

    Up to 3

    Site

    EyePoint Investigational Site, Huntington Beach, California

    Locations

    9 in total

    Run by

    EyePoint Pharmaceuticals, Inc.

    See if you can join NCT05191706 on ClinicalTrials.gov

19. Refractive Outcomes Utilizing Two SS-OCT Biometers for IOL Power Calculations

    The purpose of this study is to evaluate and compare the potential refractive outcomes using the Argos 1.5 biometer in the surgical planning for cataract extraction to that obtained from IOLMaster 700. Both devices are used as standard of care in surgical planning optimization for patients undergoi…

    Stage

    Not phased

    Ages

    21 and older

    Site

    The Eye Institute of Utah, Salt Lake City, Utah

    Run by

    The Eye institute of Utah

    See if you can join NCT06801678 on ClinicalTrials.gov

20. Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC

    This is a multicenter, 2-arm, randomized, prospective study of patients slated for bilateral cataract extraction. One eye will be randomized to the Study Arm, and the fellow eye will be randomized to the Control Arm.

    Stage

    Phase 1

    Ages

    18 and older

    Site

    The Eye Associates - Venice, Venice, Florida

    Locations

    2 in total

    Run by

    Inder Paul Singh, M.D.

    See if you can join NCT06681688 on ClinicalTrials.gov