Cardiovascular Disease Clinical Trials

22 studies are recruiting for cardiovascular disease in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Bethesda, Maryland 9 Nashville, Tennessee 4 Atlanta, Georgia 3 Birmingham, Alabama 3 Boston, Massachusetts 3 Bowie, Maryland 3 Dallas, Texas 3 Houston, Texas 3 Humble, Texas 3 Jacksonville, Florida 3 Los Angeles, California 3 Philadelphia, Pennsylvania 3 Pittsburgh, Pennsylvania 3

Studies now recruiting

  1. The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

    Background: People with systemic lupus erythematosus (SLE) are at risk of developing complications in their blood vessels. This can increase the risk of heart attacks or stroke. No medications have been effective at reducing this risk in people with lupus. Objective: To test whether a drug (anifrol…

    Stage
    Phase 2
    Ages
    18 to 80
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    See if you can join NCT05440422 on ClinicalTrials.gov

  2. Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

    Background: Studies show that rare genetic variants might lead to diseases. Researchers want to collect blood and tissue samples so they can study them and better understand diseases. Objective: To collect blood and tissue samples for studies to identify underlying causes of disease. Eligibility: P…

    Stage
    Not phased
    Ages
    0 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT02543996 on ClinicalTrials.gov

  3. Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

    Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium. The cause of these tumors is unknown, but sometimes they are inherited. Objective: To study the ge…

    Stage
    Not phased
    Ages
    7 to 70
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    See if you can join NCT03374215 on ClinicalTrials.gov

  4. Technical Development of Cardiovascular Magnetic Resonance Imaging

    Background: In the U.S., over 6.5 million people have heart failure. Researchers want to develop new testing methods for cardiovascular problems using magnetic resonance imaging (MRI) to improve the clinical diagnosis and management of people with heart failure. Objective: To develop and test new m…

    Stage
    Not phased
    Ages
    18 to 100
    Site
    Medstar Washington Hospital Center, Washington D.C., District of Columbia
    Locations
    2 in total
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT04927429 on ClinicalTrials.gov

  5. Natural History Study of CADASIL

    Background: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of the small blood vessels and can lead to strokes and dementia. Researchers want to monitor people with CADASIL over time. Objective: To learn …

    Stage
    Not phased
    Ages
    18 to 100
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT05072483 on ClinicalTrials.gov

  6. Single-tracer Multiparametric PET Imaging

    The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that qu…

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    UC Davis EXPLORER Molecular Imaging Center, Sacramento, California
    Run by
    University of California, Davis

    See if you can join NCT06014515 on ClinicalTrials.gov

  7. Feasibility of The Health Integrated Nutrition and Kidney Wellness Program

    Purpose of the Study: This clinical trial will test whether a nutrition and kidney health program can work well for adults with kidney disease. The program was created with help from patients and community partners. Main Questions: How many eligible patients choose to join the program? How many par…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UPMC Kidney Clinic - Wexford, Pittsburgh, Pennsylvania
    Locations
    5 in total
    Run by
    University of Pittsburgh

    See if you can join NCT07518719 on ClinicalTrials.gov

  8. Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

    Background: Omega-7 fatty acids are found in the oil extracted from certain fish and nuts like macadamia. Palmitoleic acid is one of the most common omega-7 fatty acids. Many studies suggest that this oil is good for heart health. Researchers want to find out more about these potential benefits. Ob…

    Stage
    Phase 2
    Ages
    18 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT03372733 on ClinicalTrials.gov

  9. Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

    Background: Heart disease is the leading cause of death, disability, and healthcare expense in the United States. Researchers think a new drug called Fx-5A may be useful to treat different cardiovascular diseases and inflammation. Objective: To understand the safety, tolerability, and effects of Fx…

    Stage
    Phase 1
    Ages
    18 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT04216342 on ClinicalTrials.gov

  10. Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention

    Background: - Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders. They will collect information about the health and health needs of people in mostly Black churches in DC. They…

    Stage
    Not phased
    Ages
    19 to 85
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT01927783 on ClinicalTrials.gov

  11. A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

    The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established ASCVD or at high risk for a first ASCVD event. The effect of AZD0780 vs p…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Research Site, Athens, Alabama
    Locations
    1452 in total
    Run by
    AstraZeneca

    See if you can join NCT07000357 on ClinicalTrials.gov

  12. WISE CVD - Continuation (WISE HFpEF)

    The Women's Ischemia Study Evaluation (WISE), a cohort study of over 1000 women, has made many contributions to the understanding of cardiovascular disease. A milestone acknowledged in the 2011 AHA Herrick Lecture is the role of Coronary Microvascular Dysfunction (CMD) in women with symptoms/signs …

    Stage
    Not phased
    Ages
    18 and older
    Site
    Cedars-Sinai Women's Heart Center, Los Angeles, California
    Run by
    Cedars-Sinai Medical Center

    See if you can join NCT02582021 on ClinicalTrials.gov

  13. OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

    The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp[a]…

    Stage
    Phase 3
    Ages
    50 to 105
    Site
    Advanced Cardiovascular LLC, Alexander City, Alabama
    Locations
    252 in total
    Run by
    Amgen

    See if you can join NCT07136012 on ClinicalTrials.gov

  14. A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

    The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for physicians to use to Prioritize Personalize Prescribe EXercise (P3-EX) to patients with ca…

    Stage
    Not phased
    Ages
    18 to 64
    Site
    Hartford HealthCare, Hartford, Connecticut
    Locations
    3 in total
    Run by
    University of Connecticut

    See if you can join NCT07238556 on ClinicalTrials.gov

  15. Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities

    This is formative evaluation trial guided by the Values Clarification Theory25 and the Cultural Values Theory26, with specific aims to: Aim 1. Develop a culturally appropriate version of the PPC Approach for older AAs with CVCs by assembling a community advisory group of 3 primary care clinicians, …

    Stage
    Not phased
    Ages
    50 to 99
    Site
    Cooper Green Mercy Hospital, Birmingham, Alabama
    Run by
    University of Alabama at Birmingham

    See if you can join NCT07748858 on ClinicalTrials.gov

  16. Gauging Outcomes of Total Milk Ingestion on Lipid and gControl

    Atherosclerotic cardiovascular disease remains the leading cause of death for adults in the United States. The cardiovascular impact of milk consumption remains a matter of long-standing scientific debate. Current guidelines for Americans recommend three daily servings of fat-free or low-fat (1%) d…

    Stage
    Not phased
    Ages
    18 and older
    Site
    UCSF Medical Center at Parnassus, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT07087184 on ClinicalTrials.gov

  17. Cardiology Biobank Registry

    In the present study, investigators intend to establish a large database of cardiovascular patients. More specifically, investigators will create a database of approximately 12,000 cardiac catheterization and heart failure patients from Emory University Hospital, the Emory Clinic, Emory University …

    Stage
    Not phased
    Ages
    20 and older
    Site
    Emory School Of Medicine, Atlanta, Georgia
    Run by
    Emory University

    See if you can join NCT00378924 on ClinicalTrials.gov

  18. Improving Veteran Referral to Cardiac Rehabilitation

    This study will test whether the Veterans Cardiac Rehabilitation Referral Program (VCR2P) improves cardiac rehabilitation participation by studying 816 Veterans across three VA medical centers in Nashville, Dallas, and Gainesville over 12 months. The trial compares referral rates from the 6 months …

    Stage
    Not phased
    Ages
    18 and older
    Site
    North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville, Florida
    Locations
    3 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT07079358 on ClinicalTrials.gov

  19. Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

    The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).

    Stage
    Phase 3
    Ages
    35 to 80
    Site
    Bridgeport Hospital, Bridgeport, Connecticut
    Locations
    40 in total
    Run by
    Amgen

    See if you can join NCT07293260 on ClinicalTrials.gov

  20. Randomized Trial of SGLT2i in Heart Transplant Recipients

    Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival. However, due to preexisting comorbidities combined with the immunosuppressive therapies required after transplantation, HTx recipients remain at high risk for kidney, car…

    Stage
    Phase 4
    Ages
    18 and older
    Site
    VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City, Utah
    Locations
    6 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT06625073 on ClinicalTrials.gov

  21. Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

    The purpose of this study is to use a non-invasive imaging technique called positron emission tomography/magnetic resonance imaging (PET/MRI) to investigate the effects of exercise on brain activity and arterial (blood vessel) inflammation in people with PTSD symptoms and evidence of or elevated ri…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Massachusetts General Hospital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT07260032 on ClinicalTrials.gov

  22. Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

    The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.

    Stage
    Phase 4
    Ages
    18 to 30
    Site
    Social Neuroscience and Health Laboratory, Chapel Hill, North Carolina
    Run by
    University of North Carolina, Chapel Hill

    See if you can join NCT06263452 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.