Cardiac Arrest Clinical Trials

15 studies are recruiting for cardiac arrest in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America

   The overall goal of this project is to design, develop, and pilot test an emergency healthcare drone delivery system suitable for rural communities that can deliver AEDs to out-of-hospital cardiac arrest (OHCA) locations more rapidly than can be achieved with current first responder and EMS systems…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Forsyth County, Clemmons, North Carolina

   Run by

   Duke University

   See if you can join NCT06229418 on ClinicalTrials.gov

2. Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children

   This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is…

   Stage

   Not phased

   Ages

   0 to 17

   Site

   American Family Children's Hospital PICU, Madison, Wisconsin

   Run by

   University of Wisconsin, Madison

   See if you can join NCT07613918 on ClinicalTrials.gov

3. Resuscitative TEE Collaborative Registry

   The general objective of this study is to evaluate the clinical impact and safety of focused, point-of-care transesophageal echocardiography (TEE) used during the evaluation of critically-ill patients in the emergency and intensive care settings. The target population for this study are critically-…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Rush University Medical Center, Chicago, Illinois

   Run by

   University of Pennsylvania

   See if you can join NCT04972526 on ClinicalTrials.gov

4. Removing Surrogates Uncertainty to Reduce Fear and Anxiety After Cardiac Events - Kids

   This pilot randomized controlled trial (RCT) will test the feasibility and acceptability of the informational intervention program, Heartsight, to reduce caregivers' uncertainty experienced throughout their child's illness trajectory after cardiac arrest. The investigator aims to enroll up to 30 ca…

   Stage

   Not phased

   Ages

   0 to 17

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT07707037 on ClinicalTrials.gov

5. fMRI in CardiaC arrEst With Uncertain Prognosis

   The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest. The main question[s] it aims to answer are: Aim 1: Determine if stimulus-based functional MRI (fMRI)-measured activa…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Brigham and Women's Hospital, Brookline, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06423768 on ClinicalTrials.gov

6. Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest

   Patients successfully resuscitated from sudden cardiac arrest are often comatose, having suffered a period of low blood flow and oxygen delivery to the brain. They are also at risk of suffering further brain injury during the immediate period after resuscitation, in which the brain's normal regulat…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania

   Run by

   Byron Drumheller

   See if you can join NCT06511999 on ClinicalTrials.gov

7. Post-CA Neuroprotection With Magnesium

   The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety…

   Stage

   Phase 1

   Ages

   18 to 85

   Site

   NYU Langone Health, New York, New York

   Run by

   NYU Langone Health

   See if you can join NCT06455514 on ClinicalTrials.gov

8. Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst

   Cardiovascular disease remains the leading cause of death in the United States. Mortality rates of cardiac arrest range from 60-85%, and approximately 80% of survivors are initially comatose. Of those who survive, 50% are left with a permanent neurological disability, and only 10% are able to resum…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of California, San Francisco, San Francisco, California

   Locations

   8 in total

   Run by

   Boston Medical Center

   See if you can join NCT03261089 on ClinicalTrials.gov

9. Early Amiodarone in Shockable Cardiac Arrest

   The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initia…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Oregon Health & Sciences University, Portland, Oregon

   Run by

   Oregon Health and Science University

   See if you can join NCT06680869 on ClinicalTrials.gov

10. Hospital Airway Resuscitation Trial

    The Hospital Airway Resuscitation Trial (HART) is a cluster-randomized, pragmatic trial of advanced airway management with a strategy of first choice supraglottic airway vs. first choice endotracheal intubation during in-hospital cardiac arrest.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Montefiore Medical Center, New York, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT05520762 on ClinicalTrials.gov

11. Quality of Pediatric Resuscitation in a Multicenter Collaborative

    This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will dete…

    Stage

    Not phased

    Ages

    0 to 18

    Site

    Kaiser Permanente, Los Angeles, California

    Locations

    61 in total

    Run by

    Children's Hospital of Philadelphia

    See if you can join NCT02708134 on ClinicalTrials.gov

12. Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study

    Aerosol Generating Medical Procedures (AGMP) are procedures that have the potential to create tiny particles suspended in the air. These particles can contain germs such as viruses. The Coronavirus Disease 2019 (COVID-19) pandemic was caused by the novel severe acute respiratory syndrome coronaviru…

    Stage

    Not phased

    Ages

    18 to 60

    Site

    Department of Emergency Medicine, Children's Hospital of Los Angeles, Los Angeles, California

    Locations

    4 in total

    Run by

    KidSIM Simulation Program

    See if you can join NCT05868239 on ClinicalTrials.gov

13. Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

    This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces chang…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Maine Medical Center, Portland, Maine

    Run by

    MaineHealth

    See if you can join NCT02664831 on ClinicalTrials.gov

14. Hydrogen's Feasibility and Safety as a Therapy in ECPR

    The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients…

    Stage

    Phase 1

    Ages

    Any age

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Locations

    4 in total

    Run by

    Boston Children's Hospital

    See if you can join NCT05574296 on ClinicalTrials.gov

15. Surviving PEA in Roanoke (SPEAR) Study

    The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire \& EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless Electrical Activity (PEA). PEA refers to a type of cardiac arrest in w…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Carilion Clinic, Roanoke, Virginia

    Run by

    Carol Bernier

    See if you can join NCT05283850 on ClinicalTrials.gov