Carcinoma, Non-Small-Cell Lung Clinical Trials

37 studies are recruiting for carcinoma, non-small-cell lung in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies, page 2

1. A Study of Sigvotatug Vedotin in Advanced Solid Tumors

   This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug …

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Alaska Oncology and Hematology, Anchorage, Alaska

   Locations

   158 in total

   Run by

   Seagen, a wholly owned subsidiary of Pfizer

   See if you can join NCT04389632 on ClinicalTrials.gov

2. A Study of LY4175408 in Participants With Advanced Cancer

   The purpose of this study is to measure the safety and efficacy of LY4175408 in participants with selected advanced cancer. In addition, this study will evaluate how much LY4175408 gets into the bloodstream, how it is broken down, and how long it takes the body to get rid of it. Participation could…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Stanford Medicine Cancer Center, Stanford, California

   Locations

   27 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07046923 on ClinicalTrials.gov

3. Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

   The purpose of this study is to assess percentage reduction in the of urine NTX and serum CTX , in patients with NSCLC and bone metastases 1) with actionable driver oncogene on standard of care (SOC) TKI at 3 months post treatment and 2) without actionable mutations on standard of care therapy (che…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   University of Colorado Hospital, Aurora, Colorado

   Locations

   2 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT03958565 on ClinicalTrials.gov

4. Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer

   This is a Phase I Trial evaluating the safety of the dietary supplement honokiol for lung cancer chemoprevention. Female or male patients aged 18 years, or older, with early stage lung cancer who have been scheduled for curative surgery will be eligible for participation in the study. The study wil…

   Stage

   Phase 1

   Ages

   18 and older

   Site

   Houston Methodist Neal Cancer Center, Houston, Texas

   Run by

   The Methodist Hospital Research Institute

   See if you can join NCT06566443 on ClinicalTrials.gov

5. MYLUNG Consortium Part 3: Observational Study

   This longitudinal study looks to quantify the testing timeline, operational barriers, and outcomes of biomarker-guided therapy in a large, community-based, and largely unselected patient population with early stage and advanced stage, treatment-naive non-small cell lung cancer, whether squamous or …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Southern Cancer Center, PC, Daphne, Alabama

   Locations

   17 in total

   Run by

   US Oncology Research

   See if you can join NCT05885698 on ClinicalTrials.gov

6. A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma

   The goal of this clinical trial is to determine clinical advantages for LP-300 in combination with carboplatin and pemetrexed in the never smoker patient population. The primary objectives of this study are to determine progression-free survival (PFS) and overall survival (OS) in the study-defined …

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Precision NextGen Oncology and Research Center, Beverly Hills, California

   Locations

   16 in total

   Run by

   Lantern Pharma Inc.

   See if you can join NCT05456256 on ClinicalTrials.gov

7. Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

   The goal of this clinical trial is to learn if Cemiplimab with chemotherapy or Cemiplimab with stereotactic body radiation therapy (SBRT) works as treatment for stages IB, II, and III (N2) Non-Small Cell Lung Cancer (NSCLC). Before surgery to remove their lung cancer, participants will take: 1. Cem…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Weill Cornell Medicine, New York, New York

   Run by

   Weill Medical College of Cornell University

   See if you can join NCT06623656 on ClinicalTrials.gov

8. Confocal Laser Endomicroscopy VERification

   The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the diagnostic yield in patients with peripheral pulmonary nodules suspect for m…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Montefiore Medical Center, New York, New York

   Locations

   5 in total

   Run by

   Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

   See if you can join NCT06079970 on ClinicalTrials.gov

9. Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

   This is a phase II trial of durvalumab and tremelimumab in combination of platinum-based chemotherapy. Patients with stage IV Non-Small-Cell-Lung Cancer (NSCLC) with human immunodeficiency virus (HIV) infection will be eligible. Patients will receive standard platinum-based chemotherapy plus durval…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Georgetown Lombardi Comprehensive Cancer Center, Washington D.C., District of Columbia

   Locations

   4 in total

   Run by

   Georgetown University

   See if you can join NCT04499053 on ClinicalTrials.gov

10. Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy

    This clinical trial plans to assess to what extent the on-treatment circulating tumor DNA (ctDNA) can predict the subset of patients with NSCLC who will respond to immunotherapy treatment only and which patients will need both immunotherapy and chemotherapy modalities for their treatment regimen.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, New Jersey

    Locations

    3 in total

    Run by

    Hackensack Meridian Health

    See if you can join NCT05715229 on ClinicalTrials.gov

11. Patient-centered, Optimal Integration of Survivorship and Palliative Care

    The goal of this study is to develop and test the feasibility of a supportive care model (POISE) for patients with metastatic Non-small Cell Lung Cancer (NSCLC). The main questions are * is POISE feasible to deliver and acceptable to patients * what is the effect of POISE on the distress patients f…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04900935 on ClinicalTrials.gov

12. Development and Analysis of a Stool Bank for Cancer Patients

    This study is aimed at understanding the impact of gut microbiota on efficacy of cancer therapies, in particular checkpoint inhibitors, and using the resulting information to design microbial immunotherapies. Although animal models are of use to determine the influences of gut and other microbiota …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Compassionate Care Research Group, Inc., Fountain Valley, California

    Locations

    2 in total

    Run by

    Persephone Biosciences

    See if you can join NCT04291755 on ClinicalTrials.gov