Cannabis Use Clinical Trials

27 studies are recruiting for cannabis use in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

  1. Acute Effects of Cannabis on Cognition and Affect

    This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two sessions. Specifically, each participant will be given active cannabis…

    Stage
    Phase 1
    Ages
    21 and older
    Site
    Washington State University, Pullman, Washington
    Run by
    Washington State University

    See if you can join NCT07296874 on ClinicalTrials.gov

  2. MATAspire: Mental Health Awareness Tailored App for Substance Prevention and Integrated Resilience Education

    The MATAspire intervention is a web-app designed to promote substance misuse prevention education and bolster protective coping skills whereby students complete six weekly interactive modules using a smart device or computer. Each module is approximately 15-20 minutes long and focuses on select sub…

    Stage
    Not phased
    Ages
    18 and older
    Site
    California State University, Northridge (CSUN), Northridge, California
    Run by
    California State University, Northridge

    See if you can join NCT06553196 on ClinicalTrials.gov

  3. Study of an Oral Fluid Testing Approach

    The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-35 years who have used cannabis at least 1 tim…

    Stage
    Not phased
    Ages
    18 to 35
    Site
    Boston Children's Hospital, Boston, Massachusetts
    Run by
    Boston Children's Hospital

    See if you can join NCT06891235 on ClinicalTrials.gov

  4. SV2A in Older Adults

    The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using [11C]UCB-J PET imaging.

    Stage
    Phase 1
    Ages
    50 and older
    Site
    Conneticut Mental Health Center, New Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT05465538 on ClinicalTrials.gov

  5. Cannabis' Impact on Alcohol Consumption

    This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which participants choose either to drink or receive monetary reinforcement f…

    Stage
    Phase 2
    Ages
    21 to 50
    Site
    Brown University, Providence, Rhode Island
    Run by
    Brown University

    See if you can join NCT05389930 on ClinicalTrials.gov

  6. HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)

    The focus of this pilot will be on falls and neurocognitive symptoms, and the impact of alcohol, cannabis use, and medications on these outcomes. The rationale is that alcohol use at any level may interact with neurocognitively active medications, alcohol, and cannabis use leading to falls and impa…

    Stage
    Phase 1
    Ages
    50 and older
    Site
    VA Connecticut Healthcare System, West Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT06513819 on ClinicalTrials.gov

  7. Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)

    Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.

    Stage
    Not phased
    Ages
    12 to 19
    Site
    AltaMed Health Services, Commerce, California
    Locations
    3 in total
    Run by
    RAND

    See if you can join NCT06699251 on ClinicalTrials.gov

  8. CARS: Cannabis and Alcohol Reduction Study

    The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.

    Stage
    Not phased
    Ages
    13 to 17
    Site
    Medical University of South Carolina, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT05486234 on ClinicalTrials.gov

  9. Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)

    This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol…

    Stage
    Not phased
    Ages
    21 to 50
    Site
    Colorado State University, Fort Collins, Colorado
    Run by
    Colorado State University

    See if you can join NCT06259916 on ClinicalTrials.gov

  10. Warrior CARE: Cannabis Behavioral Health

    This study is a randomized, controlled clinical trial to examine the therapeutic potential of cannabinoids for treating veterans with PTSD and suicidal ideation.

    Stage
    Phase 1
    Ages
    19 to 69
    Site
    Wayne State University, Detroit, Michigan
    Run by
    Wayne State University

    See if you can join NCT06381180 on ClinicalTrials.gov

  11. Testing Warning Labels for Retail Cannabis Products Using a Discrete Choice Experiment

    This discrete choice experiment (DCE) study aims to address gaps in cannabis packaging regulatory research by testing how variations in cannabis packaging and health warning design impact reactions to packaging and intentions about cannabis use. The goal of this work is to identify the most effecti…

    Stage
    Not phased
    Ages
    21 and older
    Site
    University of OKlahoma, Oklahoma City, Oklahoma
    Run by
    University of Oklahoma

    See if you can join NCT07701304 on ClinicalTrials.gov

  12. Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum

    Using both tobacco and cannabis during pregnancy is more common in minoritized groups and can make quitting smoking in pregnancy and remaining smoke free postpartum difficult. Investigators will test an intervention to address prenatal depressive symptoms to encourage people to quit tobacco and can…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Bellefield Towers, Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT07489443 on ClinicalTrials.gov

  13. Neuroimaging of Adolescent Cannabis Use Treatment

    This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete d…

    Stage
    Not phased
    Ages
    14 to 17
    Site
    Indiana University School of Medicine, Indianapolis, Indiana
    Run by
    Indiana University

    See if you can join NCT07340554 on ClinicalTrials.gov

  14. Precision Brain Stimulation to Reduce Cannabis Craving in Schizophrenia

    The central hypothesis is this: Brain circuits most relevant to cannabis use in schizophrenia are distinct from pathways identified in healthy controls who use cannabis. This study seeks to provide evidence that targeted stimulation of the DMN leads to both altered network activity and a concomitan…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    Vanderbilt Psychiatric Hospital, Nashville, Tennessee
    Run by
    Vanderbilt University Medical Center

    See if you can join NCT07196462 on ClinicalTrials.gov

  15. Neural and Psychiatric Consequences of Cannabis Use in Adolescents

    The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.

    Stage
    Not phased
    Ages
    14 to 20
    Site
    University of Miami Clinical Research Building, Miami, Florida
    Locations
    2 in total
    Run by
    University of Miami

    See if you can join NCT06941298 on ClinicalTrials.gov

  16. The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Cannabis Edibles

    This study will examine the pharmacokinetics and pharmacodynamics of delta-9-tetrahydrocannabinol (THC)-infused chocolates, gummies, and drinks. Healthy adults (N=40) will complete 9 drug administration sessions, including an overnight stay prior to each session. Participants will consume THC conta…

    Stage
    Phase 1
    Ages
    21 to 55
    Site
    Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT05602649 on ClinicalTrials.gov

  17. Effect of Cannabis on E-Cigarette Use Behavior

    The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired brea…

    Stage
    Phase 1
    Ages
    21 and older
    Site
    Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT06609109 on ClinicalTrials.gov

  18. Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults

    The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1. Does cannabis use and discontinuation impact sleep drive? 2. Does cannabis use and discontinuation impact light sensitivity…

    Stage
    Not phased
    Ages
    18 to 25
    Site
    Western Psychiatric Hospital (Thomas Detre Hall), Pittsburgh, Pennsylvania
    Run by
    University of Pittsburgh

    See if you can join NCT06743373 on ClinicalTrials.gov

  19. Cannabis-Tobacco Co-Use Treatment Study

    The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence a…

    Stage
    Phase 3
    Ages
    18 and older
    Site
    Medical University of South Carolina - Charleston, Charleston, South Carolina
    Run by
    Medical University of South Carolina

    See if you can join NCT06883162 on ClinicalTrials.gov

  20. Cannabis, Linked Emotions, and Adolescent Risk Study

    The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of …

    Stage
    Not phased
    Ages
    12 to 18
    Site
    Massachusetts General Hopsital, Boston, Massachusetts
    Run by
    Massachusetts General Hospital

    See if you can join NCT06576076 on ClinicalTrials.gov

  21. Impact of Cannabis Use During Third Molar Surgery

    This study is for people scheduled to have their wisdom teeth (third molars) removed and are going to receive drug through an IV to put them to sleep. The researchers are studying two groups: one group of people who report using recreational marijuana/THC/cannabis and another group who report not u…

    Stage
    Not phased
    Ages
    16 to 99
    Site
    University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery, Ann Arbor, Michigan
    Run by
    University of Michigan

    See if you can join NCT07423195 on ClinicalTrials.gov

  22. Effect of Cannabis on Cigarette Use Behavior

    The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon mon…

    Stage
    Phase 1
    Ages
    21 and older
    Site
    Johns Hopkins University Behavioral Pharmacology Research Unit, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT06609083 on ClinicalTrials.gov

  23. Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

    This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco. The project aims to describe the pharmacokinetics and pharmacodynamics of marijuana-tobacco co-admi…

    Stage
    Phase 2
    Ages
    21 to 65
    Site
    Zuckerberg San Francisco General Hospital, San Francisco, California
    Run by
    University of California, San Francisco

    See if you can join NCT05999383 on ClinicalTrials.gov

  24. Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)

    Through partnership with Ontracka, the HealthPartners Institute Cancer Research Center created a secure and compliant app-based technology with the ability to seamlessly collect patient-level data on symptoms, cannabis use, real-time response to cannabis consumption, and patient-reported changes in…

    Stage
    Not phased
    Ages
    18 and older
    Site
    HealthPartners Institute Cancer Research Center, Saint Louis Park, Minnesota
    Run by
    HealthPartners Institute

    See if you can join NCT07227324 on ClinicalTrials.gov

  25. Stress and Resilience

    Alcohol and cannabis are the most misused psychoactive substances in the United States. The proposed research examines how personally relevant stressful experiences may lead to alcohol and cannabis use. The proposed research is also designed to identify possible targets for prevention and treatment…

    Stage
    Not phased
    Ages
    18 to 30
    Site
    Southern Methodist University, Dallas, Texas
    Locations
    2 in total
    Run by
    University of Washington

    See if you can join NCT06457841 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.