Cannabis Use Disorder Clinical Trials

20 studies are recruiting for cannabis use disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Study of an Oral Fluid Testing Approach

   The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-30 years who have used cannabis at least 1 tim…

   Stage

   Not phased

   Ages

   18 to 30

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT06891235 on ClinicalTrials.gov

2. Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans

   Cannabis is widely used worldwide and is associated with negative outcomes including cannabis use disorder (CanUD), psychosis, and cognitive impairment amongst others. Given the legalization of "recreational" and "medical" cannabis globally, the increasing availability of cannabis, the higher poten…

   Stage

   Phase 1

   Ages

   21 to 60

   Site

   West Haven Veterans Affairs Medical Center, West Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06058702 on ClinicalTrials.gov

3. The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

   To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tight…

   Stage

   Not phased

   Ages

   18 to 59

   Site

   University of Miami, Miami, Florida

   Run by

   University of Miami

   See if you can join NCT05453513 on ClinicalTrials.gov

4. Neuroimaging of Adolescent Cannabis Use Treatment

   This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete d…

   Stage

   Not phased

   Ages

   14 to 17

   Site

   Indiana University School of Medicine, Indianapolis, Indiana

   Run by

   Indiana University

   See if you can join NCT07340554 on ClinicalTrials.gov

5. Longitudinal Outpatient Treatment for Cannabis Use Disorder

   This study is a placebo-controlled randomized trial comparing the effects of hemp-derived cannabidiol (CBD) with and without Delta-9-tetrahydrocannabinol (THC), relative to placebo, on reducing cannabis use and cannabis use disorder (CUD) symptoms in adult treatment seeking cannabis concentrate use…

   Stage

   Phase 2

   Ages

   21 and older

   Site

   University of Colorado Boulder, Boulder, Colorado

   Run by

   University of Colorado, Boulder

   See if you can join NCT06107062 on ClinicalTrials.gov

6. Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

   The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outco…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT06878859 on ClinicalTrials.gov

7. A Study of Cannabidiol in Young Adult Cannabis Users

   The investigators will study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly. The study will use a novel naturalistic cannabis administration approach, which examines ecologically valid cannabis use utilizing a mobile lab setting to a…

   Stage

   Phase 2

   Ages

   18 to 25

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06569394 on ClinicalTrials.gov

8. Cannabidiol and Cannabis Concentrate Users

   This study is a randomized, placebo-controlled, dose-ranging trial of plant-derived cannabidiol (CBD) among people who regularly use cannabis concentrates but are not trying to stop or cut down on their use. The main questions it aims to answer are whether CBD, relative to placebo, reduces cannabis…

   Stage

   Phase 2

   Ages

   25 to 60

   Site

   University of Colorado Anschutz Medical Campus, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT06575751 on ClinicalTrials.gov

9. Stress and Pain in People Living With HIV

   This is a basic human experimental study utilizing 4 groups of individuals with and without HIV and complex morbidities of cannabis use disorder and major depression who will participate in 2 sessions of the Yale Pain Stress Task (YPST) and follow-up phase to assess drug use and mood symptoms.

   Stage

   Not phased

   Ages

   18 to 68

   Site

   The Yale Stress Center, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06784908 on ClinicalTrials.gov

10. RS-tDCS for Cannabis Use Disorder: The C.A.R.E.S. Initiative

    The purpose of this sham-controlled pilot randomized controlled trial (RCT) is to evaluate the feasibility, safety, and preliminary efficacy of a one-month intervention consisting of 20 home-based active or sham RS-tDCS sessions paired with audio track guided mindfulness meditation practice in othe…

    Stage

    Not phased

    Ages

    22 to 65

    Site

    NYU Langone Health, New York, New York

    Run by

    NYU Langone Health

    See if you can join NCT07184983 on ClinicalTrials.gov

11. A Brief Intervention for Cannabis Use

    The purpose of this study is to compare two brief interventions targeting potentially problematic cannabis use in emerging adults (ages 18-25). Brief interventions are two 40-50 minute sessions separated by 1 week. Eligible emerging adults will complete a detailed cannabis assessment (biological an…

    Stage

    Not phased

    Ages

    18 to 25

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06395389 on ClinicalTrials.gov

12. Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

    The goal of this study is to understand the changes in neural correlates of reward in adolescents with and without Cannabis Use Disorder (CUD). The study will collect functional magnetic resonance imaging (fMRI) data at 3 different timepoints with the primary goals of understanding striatal reward-…

    Stage

    Not phased

    Ages

    15 to 18

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT06124846 on ClinicalTrials.gov

13. Cannabis-Tobacco Co-Use Treatment Study

    The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence a…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Medical University of South Carolina - Charleston, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT06883162 on ClinicalTrials.gov

14. Cannabis Reduction and Functional Outcomes

    This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive behavioral therapy (CBT4CBT), and financial incentives for reduction in ur…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT07218471 on ClinicalTrials.gov

15. Psilocybin-assisted Treatment for Cannabis Use Disorder

    This pilot study will evaluate the therapeutic potential of psilocybin in people with Cannabis Use Disorder (CUD). This study will examine the impact of psilocybin treatment on cannabis use and related variables in 12 people with CUD. This is an open-label proof-of-concept trial in which participan…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

    Run by

    Johns Hopkins University

    See if you can join NCT06660381 on ClinicalTrials.gov

16. SV2A Density Cannabis Use Disorder

    The main purpose of this study is to determine whether hippocampal synaptic vesicle density estimated by hippocampal [11C]APP-311/[11C]UCB-J binding in individuals diagnosed with cannabis use disorder (CUDs) improves with at least 4 weeks of confirmed abstinence from cannabis, in comparison to heal…

    Stage

    EARLY_Phase 1

    Ages

    18 to 75

    Site

    Yale University School of Medicine, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT05472818 on ClinicalTrials.gov

17. Integrated Treatment for Enhancing Growth in Recovery During Adolescence

    This is a Phase II parallel group randomized controlled trial with 294 adolescents (age: 14-21 years) with alcohol and other drug [AOD] use disorder (hereafter substance use disorder), that compares two different active psychosocial interventions designed to address adolescent substance use disorde…

    Stage

    Not phased

    Ages

    14 to 21

    Site

    UConn Health, Farmington, Connecticut

    Locations

    2 in total

    Run by

    Massachusetts General Hospital

    See if you can join NCT06395467 on ClinicalTrials.gov

18. SV2 PET Imaging With [11C]APP311

    The aim of this study is to evaluate a new SV2A tracer, [11C]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Conneticut Mental Health Center, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT03995121 on ClinicalTrials.gov

19. Mitigating PTSD-CUD After Sexual Assault

    683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD). The current proposal will test the acceptability, initial efficacy, and mechanisms underlying …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Harbor Shelter, Smithfield, North Carolina

    Locations

    6 in total

    Run by

    University of Nevada, Las Vegas

    See if you can join NCT05989841 on ClinicalTrials.gov

20. SCORE Emerging Adult Cannabis Use & Stress

    The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play in this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical intervention…

    Stage

    Phase 1

    Ages

    18 to 25

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT05885542 on ClinicalTrials.gov