Bronchopulmonary Dysplasia Clinical Trials

17 studies are recruiting for bronchopulmonary dysplasia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Inhaled Ciclesonide Study in Preterm Infants

   Our overall objective is to conduct a safety study with inhaled ciclesonide to evaluate known glucocorticoids (sGC)-related acute and intermediate toxic effects while measuring for the first time in neonates its systemic absorption and potential bioactivity (i.e. activation of primary target, the G…

   Stage

   Phase 1

   Ages

   0 to 0

   Site

   Children's Mercy Kansas City, Kansas City, Missouri

   Run by

   Venkatesh Sampath

   See if you can join NCT06589245 on ClinicalTrials.gov

2. Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

   Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their ability to select the most …

   Stage

   Not phased

   Ages

   0 to 0

   Site

   The University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   2 in total

   Run by

   University of Alabama at Birmingham

   See if you can join NCT06373289 on ClinicalTrials.gov

3. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Lucile Packard Children's Hospital, Palo Alto, California

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

4. Lipid Infusions to Optimize Nutrition Trial

   The purpose of this study is to identify survival free of bronchopulmonary dysplasia (BPD), fatty acid profiles, and early biochemical measures for oxidative stress comparing mixed oil lipid emulsion (MOLE) vs soybean oil-based lipid emulsion (SOLE) and to establish whether MOLE or SOLE is more eff…

   Stage

   Phase 2

   Ages

   Up to 0

   Site

   The University of Texas Health Science Center at Houston, Houston, Texas

   Run by

   The University of Texas Health Science Center, Houston

   See if you can join NCT06915441 on ClinicalTrials.gov

5. Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

   Bronchopulmonary Dysplasia (BPD), or chronic lung disease of prematurity, is the most consequential complication of preterm birth and is strong predictor of childhood pulmonary and neurodevelopmental disability, particularly in infants diagnosed with grade 3 BPD (ventilator dependence at 36 weeks' …

   Stage

   Not phased

   Ages

   0 to 1

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06475976 on ClinicalTrials.gov

6. Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

   The goal of this clinical trial is to learn if transpyloric tube feeding (feeding directly into the small intestine) versus gastric tube feeding tolerably and effectively reduces gastroesophageal reflux in infants born premature who have been diagnosed with bronchopulmonary dysplasia. The main ques…

   Stage

   Not phased

   Ages

   0 to 1

   Site

   Stanford University, Palo Alto, California

   Locations

   4 in total

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT06534359 on ClinicalTrials.gov

7. Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit

   Premature infants are susceptible to complications related to infrequent and non-standardized oral care. Although the benefits of frequent standardized oral care are known to reduce oral dysbiosis (increased level of potentially pathogenic bacteria) and its associated complications in critically il…

   Stage

   Not phased

   Ages

   Up to 0

   Site

   Neonatal intensive care unit at Shands children's hospital at the Univeristy of Florida, Gainesville, Florida

   Run by

   University of Florida

   See if you can join NCT06000761 on ClinicalTrials.gov

8. Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants

   The purpose of this study is to determine if postpyloric feedings effectively improve objective measures of pulmonary health in preterm infants with chronic lung disease when compared with nasogastric (NG) feedings. This research will (1) determine the optimal nutritional management to prevent a co…

   Stage

   Not phased

   Ages

   Up to 1

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT05777512 on ClinicalTrials.gov

9. The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

   DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermi…

   Stage

   Not phased

   Ages

   0 to 0

   Site

   Arkansas Children's Hospital, Little Rock, Arkansas

   Locations

   20 in total

   Run by

   University of Pennsylvania

   See if you can join NCT05446272 on ClinicalTrials.gov

10. Pharmacokinetics and Placental Transfer of Caffeine

    The goal of this study is to learn how a pregnant person's body processes caffeine and how much caffeine crosses the placenta to the baby. A small dose of caffeine will be given to each pregnant participant before delivery. Blood will be drawn to measure caffeine levels in the pregnant mother. Bloo…

    Stage

    Phase 1

    Ages

    18 and older

    Site

    Riley Hospital for Children, Indianapolis, Indiana

    Run by

    Indiana University

    See if you can join NCT07570121 on ClinicalTrials.gov

11. Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease

    The researchers have worked to create consensus recommendations among national efforts to help with the transition and coordination of care for preterm infants with lung disease around discharge from the neonatal intensive care unit to home. This study looks to evaluate implementation of the recomm…

    Stage

    Not phased

    Ages

    0 to 1

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Boston Children's Hospital

    See if you can join NCT05285345 on ClinicalTrials.gov

12. Ventilator Pressure and Optimization of Compliance and Hemodynamics

    In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocard…

    Stage

    Not phased

    Ages

    0 to 0

    Site

    Univerisity of Alabama, Birmingham, Alabama

    Run by

    University of Alabama at Birmingham

    See if you can join NCT06512935 on ClinicalTrials.gov

13. Forced Oscillometry in Infants With Bronchopulmonary Dysplasia

    The purpose of this study is to use forced oscillometry technique (FOT) to measure pulmonary mechanics and function in in term infants and premature infants with bronchopulmonary dysplasia (BPD)

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's Mercy Hospital, Kansas City, Missouri

    Run by

    Winston Manimtim

    See if you can join NCT04270045 on ClinicalTrials.gov

14. MRI in BPD Subjects

    The investigators are wanting to learn more about early development of the lungs and to help them better understand prematurity and the development of a breathing disorder call BPD (Bronchopulmonary Dysplasia)

    Stage

    Not phased

    Ages

    Up to 0

    Site

    Megan Schmitt, Cincinnati, Ohio

    Run by

    Children's Hospital Medical Center, Cincinnati

    See if you can join NCT03657693 on ClinicalTrials.gov

15. Genesis Electrical Impedance Tomography (EIT): A Preliminary Study

    The purpose of this study is to evaluate the Genesis Electrical Impedance Tomography (EIT) imaging system for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls. The EIT does not use radiation, and i…

    Stage

    Not phased

    Ages

    0 to 40

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT03797183 on ClinicalTrials.gov

16. Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)

    This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term morbidities? Oxygen (O2) is routinely used for the stabilization of preterm…

    Stage

    Not phased

    Ages

    Any age

    Site

    University of Texas Southwestern Medical Center, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05849077 on ClinicalTrials.gov

17. Gastric Feeding Versus Transpyloric Feeding in Infants with Severe Bronchopulmonary Dysplasia, a Crossover Study

    Hospitalized infants with severe bronchopulmonary dysplasia (BPD) and feeding intolerance will be randomized to 2 weeks of continuous gastric feeding or continuous transpyoloric feeding. Subjects will crossover after 2 weeks and receive 4 weeks of each feeding mode. Respiratory status will be asses…

    Stage

    Not phased

    Ages

    0 to 1

    Site

    Le Bonheur Children's Hospital, Memphis, Tennessee

    Run by

    Le Bonheur Children's Hospital

    See if you can join NCT06821776 on ClinicalTrials.gov