Bipolar Disorder Clinical Trials

33 studies are recruiting for bipolar disorder in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Houston, Texas 4 Miami, Florida 4 Orange, California 4 San Diego, California 4 Atlanta, Georgia 3 Austin, Texas 3 Belmont, Massachusetts 3 Hialeah, Florida 3 Little Rock, Arkansas 3 Orlando, Florida 3 Philadelphia, Pennsylvania 3 Richmond, Virginia 3 Staten Island, New York 3

Studies now recruiting

  1. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VMAT2 inhibitor.

    Stage
    Phase 4
    Ages
    18 and older
    Site
    Neurocrine Clinical Site, Bryant, Arkansas
    Locations
    19 in total
    Run by
    Neurocrine Biosciences

    See if you can join NCT07105111 on ClinicalTrials.gov

  2. A Study to Assess Adverse Events and How Oral ABBV-932 Moves Through the Body When Given With Oral Itraconazole in Adult Participants With Bipolar Disorder

    This study will assess the adverse events and how oral ABBV-932 moves through the body when given with oral Itraconazole in adult participants with bipolar disorder.

    Stage
    Phase 1
    Ages
    18 to 65
    Site
    CenExel Collaborative Neuroscience Research /ID# 282784, Los Alamitos, California
    Locations
    2 in total
    Run by
    AbbVie

    See if you can join NCT07071532 on ClinicalTrials.gov

  3. A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

    The purpose of this study is to assess the efficacy and safety of brenipatide when administered with standard of care (SoC), compared with placebo plus SoC in delaying the worsening of bipolar disorder symptoms. The trial is divided into three periods as follows: Screening period that will last app…

    Stage
    Phase 2
    Ages
    18 to 75
    Site
    ATP Clinical Research, Orange, California
    Locations
    87 in total
    Run by
    Eli Lilly and Company

    See if you can join NCT07286175 on ClinicalTrials.gov

  4. A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

    X-CEED is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of azetukalner in adult participants diagnosed with bipolar I or II disorder who are currently in a depressive episode (bipolar depression).

    Stage
    Phase 3
    Ages
    18 to 74
    Site
    Noble Clinical Research, Tucson, Arizona
    Locations
    44 in total
    Run by
    Xenon Pharmaceuticals Inc.

    See if you can join NCT07172516 on ClinicalTrials.gov

  5. Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

    This is a multicenter, global, 26-week, open-label study to assess the safety and tolerability of lumateperone in pediatric patients with schizophrenia, bipolar disorder or autism spectrum disorder.

    Stage
    Phase 3
    Ages
    5 to 17
    Site
    Southwest Autism Research and Resource Center, Phoenix, Arizona
    Locations
    64 in total
    Run by
    Intra-Cellular Therapies, Inc.

    See if you can join NCT06229210 on ClinicalTrials.gov

  6. Enhancing Veteran-Clinical Collaboration in VA PRRCs

    Over 60% of Veterans with serious mental illness have a service-connected disability that impairs their ability to work, go to school, and/or have successful personal lives. Although traditional treatments tend to focus on symptom remission, Veterans prioritize a range of treatment goals, including…

    Stage
    Not phased
    Ages
    18 and older
    Site
    New Mexico VA Health Care System, Albuquerque, NM, Albuquerque, New Mexico
    Locations
    3 in total
    Run by
    VA Office of Research and Development

    See if you can join NCT06898879 on ClinicalTrials.gov

  7. NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar Disorder

    Background: Mood disorders, such as bipolar disorder, can have serious effects on a person s life. People with bipolar disorder are more likely to have heart disease and abuse substances. In this natural history study, researchers would like to learn more about the connection between exercise and m…

    Stage
    Not phased
    Ages
    8 to 70
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Mental Health (NIMH)

    See if you can join NCT05669703 on ClinicalTrials.gov

  8. Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

    This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of …

    Stage
    Phase 2
    Ages
    18 to 90
    Site
    Pine Rest Christian Mental Health Services, Grand Rapids, Michigan
    Run by
    Michigan State University

    See if you can join NCT06529029 on ClinicalTrials.gov

  9. Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

    The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history d…

    Stage
    Not phased
    Ages
    3 to 99
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Mental Health (NIMH)

    See if you can join NCT00024635 on ClinicalTrials.gov

  10. Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

    The objective of this study protocol is to test whether intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) can strengthen functional connectivity with a key region in emotion regulation (ER) neurocircuitry (anterior insula, AI) and improve pe…

    Stage
    Not phased
    Ages
    24 to 65
    Site
    Martinos Center for Biomedical Imaging, Charlestown, Massachusetts
    Locations
    2 in total
    Run by
    Massachusetts General Hospital

    See if you can join NCT06274567 on ClinicalTrials.gov

  11. A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

    The purpose of this study is to evaluate the efficacy and safety of adjunctive KarXT for the treatment of mania in participants with Bipolar-I Disorder.

    Stage
    Phase 3
    Ages
    18 to 65
    Site
    Pillar Clinical Research - Bentonville, Bentonville, Arkansas
    Locations
    104 in total
    Run by
    Bristol-Myers Squibb

    See if you can join NCT07140913 on ClinicalTrials.gov

  12. Personalized Mobile Cognitive Behavioral Therapy Application

    This study aims to compare the effectiveness of a standard mobile cognitive behavioral therapy program to a personalized mobile cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minute…

    Stage
    Not phased
    Ages
    18 to 25
    Site
    Weill Cornell Medical College, New York, New York
    Run by
    Weill Medical College of Cornell University

    See if you can join NCT05699525 on ClinicalTrials.gov

  13. Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

    The purpose of this study is to test whether a dietary supplement (low-dose melatonin) commonly used to treat night owls, administered in conjunction with a behavioral sleep intervention, will help to shift the brain clock earlier and improve mood and sleep in bipolar disorder. Eligible participant…

    Stage
    Phase 2
    Ages
    18 to 60
    Site
    University of Michigan, Ann Arbor, Michigan
    Run by
    Leslie Swanson

    See if you can join NCT06226025 on ClinicalTrials.gov

  14. The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects

    The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).

    Stage
    Phase 2
    Ages
    21 to 65
    Site
    VA Connecticut Healthcare System, West Haven, Connecticut
    Run by
    Yale University

    See if you can join NCT05786066 on ClinicalTrials.gov

  15. Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study

    The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic, Rochester, Minnesota
    Run by
    Mayo Clinic

    See if you can join NCT06897670 on ClinicalTrials.gov

  16. mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders

    Veterans with bipolar disorders (BD) experience recurrent and seemingly unpredictable periods of severe impairments in psychosocial functioning, such as participation in social roles and activities. Many effective treatments for BD emphasize early detection of bipolar episodes, in order to make nec…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota
    Run by
    VA Office of Research and Development

    See if you can join NCT06204705 on ClinicalTrials.gov

  17. Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

    The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood…

    Stage
    Not phased
    Ages
    18 to 45
    Site
    McLean Hospital, Belmont, Massachusetts
    Locations
    3 in total
    Run by
    Stony Brook University

    See if you can join NCT06373016 on ClinicalTrials.gov

  18. Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

    Preliminary data have suggested that cannabidiol (CBD) may have a number of clinical benefits, including anti-anxiety and antidepressant properties. This study is a pilot open-label clinical trial assessing a custom-formulated high-CBD product over the course of 4 weeks in patients with bipolar dis…

    Stage
    Phase 2
    Ages
    18 to 65
    Site
    McLean Hospital, Belmont, Massachusetts
    Run by
    Mclean Hospital

    See if you can join NCT05457465 on ClinicalTrials.gov

  19. Cerebellar Stimulation and Cognitive Control

    The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

    Stage
    Not phased
    Ages
    18 to 90
    Site
    University of Iowa, Iowa City, Iowa
    Run by
    Krystal Parker, PhD

    See if you can join NCT03217110 on ClinicalTrials.gov

  20. University of Iowa Interventional Psychiatry Service Patient Registry

    The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion a…

    Stage
    Not phased
    Ages
    18 to 99
    Site
    University of Iowa Health Care, Iowa City, Iowa
    Run by
    Mark Niciu

    See if you can join NCT04480918 on ClinicalTrials.gov

  21. Enhanced Coordinated Specialty Care for Early Psychosis

    The goal of this clinical trial is to compare engagement in treatment in coordinated specialty care (CSC) to five extra care elements (CSC 2.0) in first-episode psychosis. The main question it aims to answer is: • Does the addition of certain elements of care increase the number of visits in treatm…

    Stage
    Not phased
    Ages
    Any age
    Site
    McLean Hospital OnTrack Clinic, Belmont, Massachusetts
    Locations
    5 in total
    Run by
    Mclean Hospital

    See if you can join NCT06071858 on ClinicalTrials.gov

  22. CBT-CP for Veterans With SMI

    Chronic musculoskeletal pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic musculoskeletal pain leads to poorer mental and physical health-related functioning, representing a critical obstacle to rehabilitation and recovery for SMI Veterans. D…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland
    Run by
    VA Office of Research and Development

    See if you can join NCT06758414 on ClinicalTrials.gov

  23. Children's Bipolar Network Treatment Trial I

    This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of this study are to (1) identify and rel…

    Stage
    Not phased
    Ages
    9 to 19
    Site
    University of California, Los Angeles, Max Gray Child and Adolescent Mood Disorders Program (CHAMP), Los Angeles, California
    Locations
    4 in total
    Run by
    University of California, Los Angeles

    See if you can join NCT05427123 on ClinicalTrials.gov

  24. Enhancing Rehabilitation for Veterans With Serious Mental Illness

    This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chro…

    Stage
    Not phased
    Ages
    18 to 83
    Site
    VA San Diego Healthcare System, San Diego, CA, San Diego, California
    Run by
    VA Office of Research and Development

    See if you can join NCT06586164 on ClinicalTrials.gov

  25. Healthy Lifestyles in Bipolar Disorder: Bay Area Study

    The goal of this clinical trial is to understand how level of adherence with time-restricted eating (TRE) predicts change in diurnal rhythms (as measured using the amplitude of diurnal peripheral clock gene expression), and how those changes predict lower mania and depressive symptoms, and downstre…

    Stage
    Not phased
    Ages
    18 to 65
    Site
    University of California Berkeley, Berkeley, California
    Run by
    University of California, Berkeley

    See if you can join NCT06555406 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.