Barrett Esophagus Clinical Trials

18 studies are recruiting for barrett esophagus in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

   The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test. Barrett's esophagus is a condition in which the flat pink lining of the swallowing tube that connects the mouth to the stomach (the esophagus) becomes damaged…

   Stage

   Not phased

   Ages

   50 and older

   Site

   University of Colorado, Aurora, Colorado

   Locations

   5 in total

   Run by

   Case Comprehensive Cancer Center

   See if you can join NCT06687603 on ClinicalTrials.gov

2. Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

   This phase II trial tests how well itraconazole works in combination with the usual standard of care endoscopy with ablation for the prevention of esophageal cancer in patients who have high-risk Barrett's esophagus (BE). BE is a condition in which the lining of the esophagus changes and becomes mo…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Michigan Rogel Cancer Center, Ann Arbor, Michigan

   Locations

   6 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT06732388 on ClinicalTrials.gov

3. Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

   The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. To diagnose and manage Barrett's esophagus and low-grade dysplasia, doctors commonly use procedures called…

   Stage

   Not phased

   Ages

   18 to 89

   Site

   University of Alabama at Birmingham, Birmingham, Alabama

   Locations

   30 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT05753748 on ClinicalTrials.gov

4. InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

   This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The …

   Stage

   Not phased

   Ages

   Any age

   Site

   Dana Farber Cancer Institute, Boston, Massachusetts

   Run by

   Dana-Farber Cancer Institute

   See if you can join NCT05463796 on ClinicalTrials.gov

5. Obeticholic Acid for Prevention in Barrett's Esophagus

   This phase II trial studies the effect of obeticholic acid in treating patients with Barrett's esophagus. Bile acids present in duodenogastroesophageal reflux contribute to neoplastic progression in Barrett's esophagus. Obeticholic acid has shown anti-cholestatic, anti-inflammatory and anti-fibroti…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   University of Kansas Cancer Center, Kansas City, Kansas

   Locations

   8 in total

   Run by

   National Cancer Institute (NCI)

   See if you can join NCT04939051 on ClinicalTrials.gov

6. Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples

   This study is looking at cells collected from the esophagus using a diagnostic device called the EndoSign® Cell Collection Device (a sponge on a thread). Subjects swallow a capsule, which dissolves in the stomach and releases a sponge that collects cells from the esophagus as the sponge is withdraw…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Gastroenterology Practice, Cordova, Tennessee

   Run by

   Cyted Health Inc

   See if you can join NCT06803927 on ClinicalTrials.gov

7. Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

   The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D). Barrett's esophagus is a common condition that …

   Stage

   Not phased

   Ages

   18 to 89

   Site

   Arizona Centers of Digestive Health, Gilbert, Arizona

   Locations

   14 in total

   Run by

   University of Colorado, Denver

   See if you can join NCT05530343 on ClinicalTrials.gov

8. Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

   This clinical trial evaluates the use of cytosponge, a minimally invasive collection device, for the detection of Barrett's esophagus (BE) in patients undergoing endoscopy. Non-endoscopic swallowable encapsulate sponge cell collection devices combined with markers for BE/esophageal adenocarcinoma (…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Mayo Clinic, Scottsdale, Arizona

   Locations

   5 in total

   Run by

   Mayo Clinic

   See if you can join NCT06071845 on ClinicalTrials.gov

9. Longitudinal Oral Microbiome Sampling for BE

   This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Michigan, Ann Arbor, Michigan

   Locations

   2 in total

   Run by

   Columbia University

   See if you can join NCT05133102 on ClinicalTrials.gov

10. Impact of RFA on Esophageal Distensibility and Mucosal Impedance

    Patients undergoing ablative therapy for management of dysplastic Barrett's Esophagus (BE) will have decreased distensibility over the course of treatment, but improvement in mucosal impedance as BE epithelia is replaced by neosquamous epithelia. This information may lead to further research in pre…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Mayo Clinic, Rochester, Minnesota

    Run by

    Mayo Clinic

    See if you can join NCT07126535 on ClinicalTrials.gov

11. Clinical Utility of WATS3D: A 5-Year Prospective Study

    The purpose of this study is to create a registry (collect data and keep it in a research database) to learn more about two methods of taking small tissue samples from your esophagus (the esophagus is the tube that carries food and liquid from your mouth to your stomach). The two methods of samplin…

    Stage

    Not phased

    Ages

    18 and older

    Site

    NYU Langone Ambulatory Care, Bethpage, New York

    Run by

    CDx Diagnostics

    See if you can join NCT04312633 on ClinicalTrials.gov

12. Endoscopic Submucosal Dissection (ESD)

    This registry is to evaluate the procedural and clinical outcomes in patients undergoing endoscopic submucosal dissection. All patients will receive standard of medical care and no experimental interventions will be performed.

    Stage

    Not phased

    Ages

    18 and older

    Site

    AdventHealth Orlando, Orlando, Florida

    Run by

    AdventHealth

    See if you can join NCT05468008 on ClinicalTrials.gov

13. Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

    This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

    Stage

    Not phased

    Ages

    18 to 90

    Site

    Mayo Clinic Health Systems - Austin, Austin, Minnesota

    Locations

    9 in total

    Run by

    Mayo Clinic

    See if you can join NCT03961945 on ClinicalTrials.gov

14. EsophaCap for the Detection of Early Esophageal Carcinoma

    This study is to identify potential biomarkers for the early detection of Barrett's Esophagus, esophageal carcinoma (both adenocarcinoma and squamous cell carcinoma), and gastric cancer via sponge cytology.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Bayview Medical Center, Baltimore, Maryland

    Locations

    2 in total

    Run by

    Johns Hopkins University

    See if you can join NCT04214119 on ClinicalTrials.gov

15. Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

    To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors

    Stage

    Not phased

    Ages

    18 to 65

    Site

    ACUTE Center for Eating Disorders and Severe Malnutrition, Denver, Colorado

    Locations

    3 in total

    Run by

    Denver Health and Hospital Authority

    See if you can join NCT06532734 on ClinicalTrials.gov

16. Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

    The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction of EAC risk. The device is a tethe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT03830801 on ClinicalTrials.gov

17. Nonendoscopic Screening for Barrett's Esophagus in Veterans Without Chronic Reflux

    The veteran population is at increased risk for EAC and its precursor lesion, Barrett's esophagus (BE), due to increased prevalence of disease risk factors compared to the general population. BE is traditionally diagnosed only when patients undergo endoscopy with biopsies. However, due to the high …

    Stage

    Not phased

    Ages

    40 to 85

    Site

    VA Northeast Ohio Healthcare System, Cleveland, Ohio

    Run by

    Louis Stokes VA Medical Center

    See if you can join NCT06746623 on ClinicalTrials.gov

18. Patient Preferences for Barrett's Esophagus and Esophageal Cancer Screening Tests

    This study plans to learn more about what patients think about screening for esophageal cancer (EAC) and Barrett's esophagus (BE); a pre-cancerous condition associated with esophageal cancer. The plan is to use this information to modify screening practices in the United States with the goal to dec…

    Stage

    Not phased

    Ages

    18 to 89

    Site

    University of Colorado Anschutz Medical Campus, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06693622 on ClinicalTrials.gov