Atrial Fibrillation (AF) Clinical Trials

21 studies are recruiting for atrial fibrillation (af) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable

   This study is researching 2 different experimental drugs called REGN7508 and REGN9933 (called "study drugs"). The study is focused on people who have atrial fibrillation, which means that the heart beats too fast and unevenly. When this happens, blood cannot move smoothly through the heart; it can …

   Stage

   Phase 3

   Ages

   18 and older

   Site

   SEC Clinical Research, Dothan, Alabama

   Locations

   35 in total

   Run by

   Regeneron Pharmaceuticals

   See if you can join NCT07430956 on ClinicalTrials.gov

2. Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

   This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called apixaban. The study is focused on people who have atrial fibrillation, which means that the heart beats too fast and unevenly. The aim of the study is to see how…

   Stage

   Phase 3

   Ages

   18 and older

   Site

   Advanced Cardiovascular, Alexander City, Alabama

   Locations

   32 in total

   Run by

   Regeneron Pharmaceuticals

   See if you can join NCT07626411 on ClinicalTrials.gov

3. Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation

   This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillat…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   SEC Clinical Research, Dothan, Alabama

   Locations

   81 in total

   Run by

   Regeneron Pharmaceuticals

   See if you can join NCT07175428 on ClinicalTrials.gov

4. Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation

   Heart failure and atrial fibrillation are two of the most common heart diseases globally. Nearly half of all patients with heart failure also have atrial fibrillation. When heart failure and atrial fibrillation occur together, the risk of hospitalization and premature death increases significantly.…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Division of Cardiovascular & Pulmonary Diseases, Oslo University Hospital, Oslo, Oslo

   Locations

   15 in total

   Run by

   Oslo University Hospital

   See if you can join NCT07436299 on ClinicalTrials.gov

5. BOdygUardian MOnitoriNg for ReCurrencE of AF

   The DISRUPT-AF Registry is an observational, prospective, multi-center, non-randomized, real-world registry designed to obtain clinical experience with the FARAPULSE Pulsed Field Ablation (PFA) System for the treatment of atrial fibrillation (AF). The data collected for this study will be from a su…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Arrhythmia Center of South Florida, Delray Beach, Florida

   Locations

   5 in total

   Run by

   Heart Rhythm Clinical and Research Solutions, LLC

   See if you can join NCT07671677 on ClinicalTrials.gov

6. PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF

   Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for…

   Stage

   Not phased

   Ages

   60 to 99

   Site

   Northwestern University, Chicago, Illinois

   Run by

   Northwestern University

   See if you can join NCT07324772 on ClinicalTrials.gov

7. Detection of Atrial Fibrillation Using PPG From Smartphone Cameras

   The protocol is designed to enroll patients from at least 3 diverse clinical sites with smartphones who are being evaluated for the presence or absence of atrial fibrillation (AF) using the Heart Rhythm Software algorithm running on their smartphones. Algorithm output will be compared to a gold sta…

   Stage

   Not phased

   Ages

   Any age

   Site

   Nair Research, LLC dba Arrhythmia Research Group LLC, Jonesboro, Arkansas

   Locations

   5 in total

   Run by

   Happitech BV

   See if you can join NCT07779213 on ClinicalTrials.gov

8. Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

   Conquer-AF is a prospective, multi-center, interventional, non-randomized clinical study that will enroll up to 400 subjects at up to 30 sites across the United States, Europe, and Australia. Subjects diagnosed with symptomatic recurrent paroxysmal or persistent atrial fibrillation after a single p…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama

   Locations

   30 in total

   Run by

   Medtronic Cardiac Ablation Solutions

   See if you can join NCT07298473 on ClinicalTrials.gov

9. Prospective Remapping With Concomitant Left Atrial Appendage Occlusion to Ensure Durable Electroporation Study

   This is a single-arm, open label, clinical outcome study to research the durability (success) of receiving a pulsed field ablation (PFA) per standard of care for treatment of atrial fibrillation during a subsequent procedure for the insertion of a left atrial appendage occlusion (LAAO) device. The …

   Stage

   Not phased

   Ages

   18 and older

   Site

   South Shore University Hospital, Bay Shore, New York

   Run by

   Northwell Health

   See if you can join NCT07620262 on ClinicalTrials.gov

10. Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation

    To evaluate the safety and effectiveness of the Argá Medtech CSE Ablation System in the treatment of atrial fibrillation.

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Grandview, Birmingham, Alabama

    Locations

    27 in total

    Run by

    Arga Medtech SA

    See if you can join NCT06784466 on ClinicalTrials.gov

11. Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

    A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.

    Stage

    Phase 3

    Ages

    65 and older

    Site

    Anthos Investigative Site 1040, Birmingham, Alabama

    Locations

    789 in total

    Run by

    Anthos Therapeutics, Inc.

    See if you can join NCT05712200 on ClinicalTrials.gov

12. Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)

    The goal of this randomized clinical trial is to learn whether patients with symptomatic atrial fibrillation or atrial flutter (AF) who require heart imaging to rule out a blood clot before cardioversion would benefit from cardiac computed tomography angiography (CCT) in the emergency department (E…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania

    Locations

    3 in total

    Run by

    Ottawa Heart Institute Research Corporation

    See if you can join NCT07002450 on ClinicalTrials.gov

13. Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation

    The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF). Current guidelines recommend continued anticoagulation based on stroke risk scores, even post-ablation, potentially exposing patients to unnecessary …

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    Fuwai Hospital, Beijing, Beijing Municipality

    Locations

    12 in total

    Run by

    China National Center for Cardiovascular Diseases

    See if you can join NCT06615596 on ClinicalTrials.gov

14. Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

    The goal of this clinical trial is to compare the use of the Vektor Computational ECG Mapping System (vMap®) with pulmonary vein isolation (PVI), to using PVI alone, to treat Atrial Fibrillation (AF) in adults. Participants will have a 50/50 or 1 out of 2 chance of being placed in the treatment or …

    Stage

    Not phased

    Ages

    22 and older

    Site

    Arrhythmia Research Group - St. Bernards, Jonesboro, Arkansas

    Locations

    13 in total

    Run by

    Vektor Medical

    See if you can join NCT06935591 on ClinicalTrials.gov

15. Incidence of Long-TeRm Atrial Fibrillation After Acute Illness

    The investigators seek to conduct a prospective study to assess the recurrence of AF in patients with acute AF using a long-term ECG monitoring strategy with an insertable cardiac monitor (ICM), which is clinically indicated in this scenario as part of the standard of care. The investigators hypoth…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Sulpizio Cardiovascular Center, La Jolla, California

    Run by

    University of California, San Diego

    See if you can join NCT07434674 on ClinicalTrials.gov

16. Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

    Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study ai…

    Stage

    Not phased

    Ages

    21 and older

    Site

    UCSF Medical Center at Parnassus, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT07220525 on ClinicalTrials.gov

17. Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation

    The goal of this study is to assess the short-term effects of minimal and moderate drinking on atrial fibrillation (AFib) episodes in a real-world population diagnosed with 'come-and-go'/paroxysmal AFib. The question it aims to answer is: Is there a greater occurrence of AFib episodes when particip…

    Stage

    Not phased

    Ages

    21 and older

    Site

    UCSF Medical Center at Parnassus, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT06754176 on ClinicalTrials.gov

18. Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity

    Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol. Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 10 million individuals in U.S., comprising 4.5% of the adult …

    Stage

    Not phased

    Ages

    21 and older

    Site

    UCSF Medical Center at Parnassus, San Francisco, California

    Run by

    University of California, San Francisco

    See if you can join NCT06995391 on ClinicalTrials.gov

19. Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

    PAUSE 2 study is a prospective, open-label, blinded-endpoint non-inferiority RCT of PAUSE vs. ASRA management in DOAC treated high risk patients with AF/VTE who need elective high bleed risk surgery/procedure and/or any procedure involving neuraxial anesthesia. The purpose of the PAUSE 2 study is t…

    Stage

    Not phased

    Ages

    18 and older

    Site

    St. Joesph's Healthcare, Hamilton, Ontario

    Locations

    14 in total

    Run by

    McMaster University

    See if you can join NCT06957366 on ClinicalTrials.gov

20. Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)

    The purpose of the PAUSE-Virtual Study is to show that by changing pre-surgery visits with patients taking a blood thinner (direct oral anticoagulant (apixaban, dabigatran, edoxaban, rivaroxaban or warfarin) when the participant requires elective surgery, using a standard, in-person proven approach…

    Stage

    Not phased

    Ages

    18 to 100

    Site

    Endeavor Health - Northshore, Evanston, Illinois

    Locations

    10 in total

    Run by

    McMaster University

    See if you can join NCT06844227 on ClinicalTrials.gov

21. Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.

    Information gathered from the patients via a disease specific questionnaire will be married to data from the National Cardiovascular Data Registry (NCDR®). Details will be continuously analyzed and used to direct quality of care at our center. The institution is categorized as a low-volume institut…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Valley View Hospital, Glenwood Springs, Colorado

    Run by

    Cardiovascular Innovation and Research Institute

    See if you can join NCT03428048 on ClinicalTrials.gov