Atherosclerosis Clinical Trials

18 studies are recruiting for atherosclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Causes and Natural History of Dyslipidemias

   This study will evaluate people with dyslipidemias - disorders that affect the fat content in the blood. Fats, or lipids, such as cholesterol and triglycerides, are carried in the blood in particles called lipoproteins. These particles are involved in causing blood vessel diseases that can lead to …

   Stage

   Not phased

   Ages

   2 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT00353782 on ClinicalTrials.gov

2. Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

   Background: - Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected in…

   Stage

   Not phased

   Ages

   1 to 100

   Site

   Hope Center, Washington D.C., District of Columbia

   Locations

   3 in total

   Run by

   National Heart, Lung, and Blood Institute (NHLBI)

   See if you can join NCT01143454 on ClinicalTrials.gov

3. Study of the Effect of Innate on the Inflammatory Response to Endotoxin

   Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s re…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina

   Run by

   National Institute of Environmental Health Sciences (NIEHS)

   See if you can join NCT01143480 on ClinicalTrials.gov

4. A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis

   This study is designed to evaluate the efficacy and safety of intravenously administered YN001 in patients diagnosed with coronary atherosclerosis, who are receiving background therapy for cardiovascular (CV) risk factors management.

   Stage

   Phase 2

   Ages

   18 to 80

   Site

   Washington University School of Medicine, St Louis, Missouri

   Locations

   40 in total

   Run by

   Beijing Inno Medicine Co., Ltd.

   See if you can join NCT07521007 on ClinicalTrials.gov

5. A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

   Lipoprotein(a), also known as Lp(a), is a protein that carries cholesterol and proteins in your blood. People with high Lp(a) have a higher risk for heart disease. The main purpose of the study is to investigate how lepodisiran, compared to a placebo, affects the amount and type of plaque in the he…

   Stage

   Phase 3

   Ages

   45 to 80

   Site

   Valley Clinical Trials, Inc., Northridge, California

   Locations

   58 in total

   Run by

   Eli Lilly and Company

   See if you can join NCT07613294 on ClinicalTrials.gov

6. New Heart Imaging Techniques to Evaluate Possible Heart Disease

   Background: - Imaging tests, such as magnetic resonance imaging (MRI), can provide information about heart and blood vessels. The tests let doctors can see the amount of blood vessel narrowing and vessel wall thickness. This information may help diagnose and treat heart disease and other conditions…

   Stage

   Not phased

   Ages

   18 to 100

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

   See if you can join NCT01399385 on ClinicalTrials.gov

7. A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events

   The main purpose of the study is to evaluate the efficacy of selnoflast compared with placebo in participants with atherosclerosis, at high-risk for major adverse cardiovascular event (MACE), who are currently on standard-of-care (SOC) therapy.

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Cardiovascular Research Foundation of Southern California, Beverly Hills, California

   Locations

   24 in total

   Run by

   Genentech, Inc.

   See if you can join NCT07448038 on ClinicalTrials.gov

8. PET/CT* vs. Cardiac CT for Detecting Coronary Atherosclerotic Disease [*PET: Positron Emission Tomography; CT: Computed Tomography]

   Early detection of coronary atherosclerotic disease facilitates adequate prevention. The purpose of this study is to compare an assessment of coronary atherosclerotic disease burden by positron emission tomography / computed tomography (NaF-PET/CT) with those of conventional and ultra-high-resoluti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Johns Hopkins Hospital, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05994014 on ClinicalTrials.gov

9. Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

   This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

   Stage

   Not phased

   Ages

   65 to 84

   Site

   Keck School of Medicine, University of Southern California, Los Angeles, California

   Run by

   University of Southern California

   See if you can join NCT05867381 on ClinicalTrials.gov

10. Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

    The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in individuals with increased psychosocial stress.

    Stage

    Not phased

    Ages

    30 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04496947 on ClinicalTrials.gov

11. High Protein Diet and Atherosclerosis

    Atherosclerosis is the underlying cause of the majority of cardiovascular diseases, including myocardial infarction and strokes, and results in tremendous morbidity and mortality. A Western-type diet is a major risk factor for atherosclerosis because of the high saturated fat, cholesterol, and refi…

    Stage

    Not phased

    Ages

    45 to 75

    Site

    University of Missouri School of Medicine, Columbia, Missouri

    Run by

    University of Missouri-Columbia

    See if you can join NCT05235464 on ClinicalTrials.gov

12. Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions

    Background: The right amount of fats in the blood (cholesterol and triglycerides) are a key part of a healthy organism. Too much or too little of these fats may manifest as diseases (dyslipidemia). There are many causes for these abnormalities, but some are genetically determined and we would like …

    Stage

    Not phased

    Ages

    10 to 90

    Site

    National Institutes of Health Clinical Center, Bethesda, Maryland

    Run by

    National Heart, Lung, and Blood Institute (NHLBI)

    See if you can join NCT06676046 on ClinicalTrials.gov

13. The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

    This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial…

    Stage

    Not phased

    Ages

    45 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT04505865 on ClinicalTrials.gov

14. Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial

    Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders (EMERALD) is a protocolized intervention based on American College of Cardiology/American Heart Association and US Preventive Services Task Force guidelines designed to initiate preventive cardiovascular care for emergency depart…

    Stage

    Phase 2

    Ages

    40 to 75

    Site

    Wake Forest University Health Sciences, Winston-Salem, North Carolina

    Run by

    Wake Forest University Health Sciences

    See if you can join NCT06488105 on ClinicalTrials.gov

15. Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes

    This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

    Locations

    40 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT02915198 on ClinicalTrials.gov

16. Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

    This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by FDG-PET/CT, lipids, inflammation, immune activation, …

    Stage

    Phase 2

    Ages

    40 and older

    Site

    UCLA Center for Clinical AIDS Research and Education (CARE), Los Angeles, California

    Locations

    3 in total

    Run by

    Priscilla Hsue, MD

    See if you can join NCT05488431 on ClinicalTrials.gov

17. Text Education About Cardiovascular Health and HIV (TEACH-HIV)

    The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).

    Stage

    Not phased

    Ages

    40 and older

    Site

    Zuckerberg San Francisco General Hospital, San Francisco, California

    Locations

    2 in total

    Run by

    University of California, San Francisco

    See if you can join NCT05642858 on ClinicalTrials.gov

18. Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT

    A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of type II Diabetes (T2DM) and atheros…

    Stage

    Phase 4

    Ages

    40 to 80

    Site

    Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute), Torrance, California

    Run by

    Matthew J. Budoff

    See if you can join NCT05708859 on ClinicalTrials.gov