Asthma in Children Clinical Trials

24 studies are recruiting for asthma in children in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. SMART Implementation-Effectiveness Trial 1

   While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been rigorously assessed. This study will test electronic medical record clini…

   Stage

   Not phased

   Ages

   5 to 18

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT07137923 on ClinicalTrials.gov

2. SMART Implementation-Effectiveness Trial 2

   While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been rigorously assessed. This study will test population health management (P…

   Stage

   Not phased

   Ages

   5 to 18

   Site

   Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

   Run by

   Children's Hospital of Philadelphia

   See if you can join NCT07138027 on ClinicalTrials.gov

3. Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

   Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Ea…

   Stage

   Not phased

   Ages

   0 to 6

   Site

   Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

   Run by

   Ann & Robert H Lurie Children's Hospital of Chicago

   See if you can join NCT05336890 on ClinicalTrials.gov

4. Smart Inhaler and Remote Asthma Management in Adolescents With Intellectual and Developmental Disabilities

   Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use. Smart inhalers, a novel technology that provides guidance and immediate feedback on inha…

   Stage

   Not phased

   Ages

   10 to 17

   Site

   Children's Hospital Los Angeles, Los Angeles, California

   Run by

   Children's Hospital Los Angeles

   See if you can join NCT07746921 on ClinicalTrials.gov

5. Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

   The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK…

   Stage

   Not phased

   Ages

   0 to 20

   Site

   Lucile Packard Children's Hospital, Palo Alto, California

   Locations

   52 in total

   Run by

   Duke University

   See if you can join NCT04278404 on ClinicalTrials.gov

6. Implementation of Asthma Community Home and School Management Program (Asthma CHAMPS)

   The long-term goal is to implement an evidence-based asthma intervention based on the Center for Disease Control's recommended framework (EXHALE) within Baltimore City Public Schools (BCPS). As part of a stepped wedge pragmatic trial the investigators will: 1. Evaluate the effectiveness of a tailor…

   Stage

   Not phased

   Ages

   Any age

   Site

   Baltimore City Public Schools, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05814510 on ClinicalTrials.gov

7. Mechanistic Study of Inspiratory Training in Childhood Asthma (MICA)

   This is single-center cross-sectional mechanistic study in lean and obese children with moderate-severe asthma, followed by a randomized, SHAM-controlled trial of Inspiratory Training (IT). The primary outcome is to describe the contributions of inspiratory muscle dysfunction (IMD) and Small Airway…

   Stage

   Not phased

   Ages

   6 to 17

   Site

   Duke Health Center Creekstone, Durham, North Carolina

   Locations

   2 in total

   Run by

   Duke University

   See if you can join NCT05945355 on ClinicalTrials.gov

8. Y of Central Maryland Head Start Asthma Implementation

   Despite a strong evidence-base for the efficacy of multilevel programs in reducing asthma symptoms among low-income preschool minority children, gaps remain in our understanding of how to best translate and scale up these efficacious interventions into sustainable programs that reduce known asthma …

   Stage

   Not phased

   Ages

   18 and older

   Site

   Easter Seals Head Start Prince George's County, District Heights, Maryland

   Locations

   2 in total

   Run by

   Johns Hopkins University

   See if you can join NCT05004714 on ClinicalTrials.gov

9. SMART@Home Feasibility Trial

   The proposed research addresses the limitations or lack of a digital platform to provide remote care of medically complex patients. Previous attempts have had poor clinical validity and suffered lack of patient engagement. The study team will deconstruct the previously implemented SMART platforms t…

   Stage

   Not phased

   Ages

   12 to 18

   Site

   Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

   Run by

   Children's Hospital Medical Center, Cincinnati

   See if you can join NCT06159127 on ClinicalTrials.gov

10. Project ASTHMA - Aligning With Schools To Help Manage Asthma and Improve Outcomes

    Children with asthma from communities that experience health inequities frequently do not receive guideline-based asthma care, and as a result, account for a disproportionate percentage of asthma exacerbations, emergency department visits, and hospitalizations. Project ASTHMA (Aligning with Schools…

    Stage

    Not phased

    Ages

    4 to 13

    Site

    University at Buffalo, Department of Pediatrics, Buffalo, New York

    Run by

    State University of New York at Buffalo

    See if you can join NCT06539312 on ClinicalTrials.gov

11. Telehealth-Enhanced Asthma Care for Home After the Emergency Room

    The investigators propose a randomized controlled trial of Telehealth-Enhanced Asthma Care for Home After the Emergency Room (TEACH-ER) vs. enhanced care (EC). TEACH-ER includes: 1) brief, pictorial, and health literacy-informed asthma education in the ED, with color- and shape-coded labels provide…

    Stage

    Not phased

    Ages

    3 to 12

    Site

    University of Rochester Medical Center, Rochester, New York

    Run by

    University of Rochester

    See if you can join NCT05844891 on ClinicalTrials.gov

12. Promoting Asthma Management Guidelines With Technology-Based Intervention and Care Coordination in Clinics and Schools

    The overall goal of this research study is to evaluate a multi-level program called PRAGMATIC-S to improve the delivery of guideline-based asthma care through a unique partnership between clinical practices and schools. PRAGMATIC-S represents a novel approach that addresses multiple barriers to adh…

    Stage

    Not phased

    Ages

    4 to 12

    Site

    Children's Hospital at Montefiore, Albert Einstein College of Medicine, The Bronx, New York

    Run by

    Montefiore Medical Center

    See if you can join NCT07224061 on ClinicalTrials.gov

13. Hospital to Home Study: Trial to Optimize Transitions and Address Disparities in Asthma Care

    Caregiver-child dyads will be recruited during child's hospital admission for asthma exacerbation. Recruitment sites will be mainly Children's National Hospital Sheikh Zayed campus, as well as regional partners: Holy Cross Hospital, and Mary Washington Hospital. After enrollment, baseline data will…

    Stage

    Not phased

    Ages

    4 to 12

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Kavita Parikh

    See if you can join NCT05991115 on ClinicalTrials.gov

14. A Clinical Trial of Soluble Fiber for Asthma

    Randomized controlled trial of soluble fiber (Fruitafit Inulin). Participants will complete an ASA 24 dietary recall questionnaire to access their fiber intake. If eligible for the study, participants will be supplemented to their target fiber dosage with either soluble fiber (Fruitafit Inulin) or …

    Stage

    Phase 2

    Ages

    6 to 17

    Site

    Phoenix Children's, Phoenix, Arizona

    Run by

    Phoenix Children's Hospital

    See if you can join NCT06372249 on ClinicalTrials.gov

15. The Exhale Study: Treating Maternal Depression in an Urban Pediatric Asthma Clinic

    The goal of this clinical trial is to test the effectiveness and implementation of delivering Enhanced Brief Interpersonal Psychotherapy (IPT-B), an evidence-based maternal depression treatment, to mothers of children under the age of 18 in an urban pediatric asthma clinic. Researchers will compare…

    Stage

    Not phased

    Ages

    Any age

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT06623981 on ClinicalTrials.gov

16. Soy Isoflavones For Inner City Infants At Risk For Asthma (SIRA) Study

    The goal of this clinical trial is to compare soy isoflavones to placebo in children who at risk of asthma and have a genetic variation which results in them making more of a pro-inflammatory protein, plasminogen activator inhibitor-1. The main questions this trail seeks to answer is: will soy isof…

    Stage

    Phase 2

    Ages

    0 to 1

    Site

    Ann and Robert H Lurie Childrens Hospital of Chicago, Chicago, Illinois

    Locations

    2 in total

    Run by

    Rajesh Kumar

    See if you can join NCT05667701 on ClinicalTrials.gov

17. Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline

    The goal of this study is to evaluate the effectiveness of CHAMPION ("Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline"), a primary care-based intervention to address childhood obesity and asthma, and test the effectiveness of a telehealth-only ver…

    Stage

    Not phased

    Ages

    4 to 17

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06432790 on ClinicalTrials.gov

18. Technology-Enhanced Asthma Care in Children at Clinic and Home Study

    A randomized controlled trial with parent-child pairs of children with persistent or uncontrolled asthma. An intervention group (n=40 parent-child pairs) will receive the mobile health (mHealth) app and digital sensors with enhanced support from a population health manager role, hereinafter referre…

    Stage

    Not phased

    Ages

    4 and older

    Site

    Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois

    Run by

    Ann & Robert H Lurie Children's Hospital of Chicago

    See if you can join NCT06820593 on ClinicalTrials.gov

19. The Allergen Reduction and Child Health Study (ARCHS)

    The Allergen Reduction and Child Health Study (ARCHS) is a 12-month, two group randomized control trial of children with asthma and who are exposed to cockroaches. Children ages 5 - 17 living in the Greater New Orleans area will be recruited from a variety of clinic and community settings. The over…

    Stage

    Not phased

    Ages

    5 to 17

    Site

    Tulane University, New Orleans, Louisiana

    Run by

    Tulane University

    See if you can join NCT04331353 on ClinicalTrials.gov

20. Omalizumab Before Onset of Exacerbations

    OBOE is a prospective, pilot, parallel group RCT with the overall aim of examining the effect of a single dose of anti-IgE (omalizumab) vs. placebo administered at the onset of URIs in the fall season among highly exacerbation-prone, urban, and atopic youth aged 6-17 years with persistent asthma. O…

    Stage

    Phase 2

    Ages

    6 to 17

    Site

    Children's National Hospital, Washington D.C., District of Columbia

    Run by

    Children's National Research Institute

    See if you can join NCT05332067 on ClinicalTrials.gov

21. Navigating Together for Equitable Asthma Management for Children in Families Who Communicate in Language Other Than English

    The Nav-Team study reviews how well the asthma navigators/coordinator program can improve the lives of asthmatic children, and their caregivers, by providing additional assistance and education. Aim 1 of the study will partner with immigrant serving community organizations to hold meetings that wil…

    Stage

    Not phased

    Ages

    4 to 89

    Site

    Children's Hospital Colorado, Aurora, Colorado

    Run by

    University of Colorado, Denver

    See if you can join NCT06239844 on ClinicalTrials.gov

22. Using a Smart Inhaler to Support Asthma Management in Adolescents With Intellectual and Developmental Disabilities

    Correct use of daily medications containing inhaled corticosteroids is key for asthma control, yet children with intellectual and developmental disabilities (IDD) face additional barriers to proper inhaler use. Smart inhalers, a novel technology that provides guidance and immediate feedback on inha…

    Stage

    Not phased

    Ages

    10 to 17

    Site

    Children's Hospital Los Angeles, Los Angeles, California

    Run by

    Children's Hospital Los Angeles

    See if you can join NCT06783101 on ClinicalTrials.gov

23. Timely Administration of IV Magnesium Sulfate in Patients With a Moderate Asthma Exacerbation

    This study aims to identify whether early administration of magnesium sulfate in moderate asthma exacerbations can potentially avoid admission, decrease length of stay in the emergency department (ED), decrease length of stay (LOS) in the general hospital floor vs pediatric intensive care unit (PIC…

    Stage

    EARLY_Phase 1

    Ages

    5 to 17

    Site

    Oklahoma Children's Hospital, Oklahoma City, Oklahoma

    Run by

    University of Oklahoma

    See if you can join NCT06137040 on ClinicalTrials.gov

24. Action Towards Health Equity and Improved Air Quality in the Duwamish Valley: A Multilevel Asthma Intervention

    The goal of this randomized control trial is to learn if box fans and filters can reduce asthma symptoms and improve indoor air quality in children ages 6 - 17 years old with asthma living in the Duwamish Valley, Seattle, Washington. The main question it aims to answer are: * Do box fans with filte…

    Stage

    Not phased

    Ages

    6 to 17

    Site

    Duwamish River Community Coaltion, Seattle, Washington

    Run by

    University of Washington

    See if you can join NCT06552013 on ClinicalTrials.gov