Aphasia Clinical Trials

29 studies are recruiting for aphasia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Effects of Recursive Self-feedback on Speech Production in Aphasia

   The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia). The main question it aims to answer is: • To what extent can stroke survivors with aphasia use their self-feed…

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Brain and Aphasia Recovery Lab, PCD 1030, Department of Communication Sciences and Disorders, University of South Florida, Tampa, Florida

   Run by

   University of South Florida

   See if you can join NCT06323629 on ClinicalTrials.gov

2. Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine

   The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Imple…

   Stage

   Not phased

   Ages

   18 to 99

   Site

   Johns Hopkins School of Medicine, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT05845047 on ClinicalTrials.gov

3. Escitalopram and Language Intervention for Subacute Aphasia

   In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute pos…

   Stage

   Phase 2

   Ages

   18 to 99

   Site

   Johns Hopkins School of Medicine, Baltimore, Maryland

   Locations

   3 in total

   Run by

   Johns Hopkins University

   See if you can join NCT03843463 on ClinicalTrials.gov

4. tACS to Enhance Language Abilities

   The goal of this study is to see if transcranial alternating current stimulation (tACS) can be used to enhance language abilities in people with post-stroke aphasia. Participants will receive real and sham tACS in conjunction with various language tests. Researchers will compare the post-stroke aph…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   University of Pennsylvania, Philadelphia, Pennsylvania

   Run by

   University of Pennsylvania

   See if you can join NCT06092814 on ClinicalTrials.gov

5. Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia

   The goal of this clinical trial is to learn whether healthy volunteers are more successful at understanding people with aphasia if they have first viewed an aphasia identification (ID) card. The main questions this study aims to answer are: * Does viewing an aphasia ID card improve healthy voluntee…

   Stage

   Not phased

   Ages

   18 to 59

   Site

   UMass Amherst Henry M. Thomas III Center at Springfield, Springfield, Massachusetts

   Run by

   University of Massachusetts, Amherst

   See if you can join NCT06990997 on ClinicalTrials.gov

6. Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits

   The goal of the proposed project is to test the effectiveness of a novel hybrid approach to treatment of reading disorders after stroke, in which exercise training will be used in combination with a targeted reading treatment. This approach is expected to increase cerebral circulation and help to r…

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Kessler Foundation, West Orange, New Jersey

   Run by

   Kessler Foundation

   See if you can join NCT06213272 on ClinicalTrials.gov

7. Transcranial Alternating Current Stimulation (tACS) in Aphasia

   This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Medical College of Wisconsin, Milwaukee, Wisconsin

   Run by

   Medical College of Wisconsin

   See if you can join NCT04375722 on ClinicalTrials.gov

8. Neural Bases of Vocal Sensorimotor Impairment in Aphasia

   Aphasia is the most common type of post-stroke communication disorder characterized by deficits in speech comprehension, production and control. While recovery can be promoted with speech therapy, improvement remains modest and typically requires a large number of sessions contributing to rising he…

   Stage

   Not phased

   Ages

   21 to 75

   Site

   The University of Texas at Dallas, Richardson, Texas

   Locations

   3 in total

   Run by

   The University of Texas at Dallas

   See if you can join NCT04742894 on ClinicalTrials.gov

9. Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation

   The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.

   Stage

   Phase 2

   Ages

   25 to 80

   Site

   Medical University of South Carolina, Charleston, South Carolina

   Locations

   3 in total

   Run by

   University of South Carolina

   See if you can join NCT07688551 on ClinicalTrials.gov

10. Language Processing and TMS

    This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.

    Stage

    Not phased

    Ages

    18 to 85

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT05425615 on ClinicalTrials.gov

11. Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke

    This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06048159 on ClinicalTrials.gov

12. Post-Stroke Aphasia TMS

    The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical College of Wisconsin, Milwaukee, Wisconsin

    Run by

    Medical College of Wisconsin

    See if you can join NCT06974279 on ClinicalTrials.gov

13. Neuroplasticity Biomarkers in Aphasia

    Patients with stroke frequently suffer from aphasia, a disorder of expressive and/or receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals…

    Stage

    Not phased

    Ages

    40 to 90

    Site

    UW School of Medicine and Public Health, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT06471127 on ClinicalTrials.gov

14. Comparing Traditional Semantic Feature Analysis (tSFA) and Semantic Feature Analysis + Metacognitive Strategy Training (SFA+MST)

    The goal of this clinical trial is to compare the effectiveness of traditional Semantic Feature Analysis (SFA) treatment to a modified SFA protocol that includes Metacognitive Strategy Training (SFA+MST) for adults with acquired aphasia. The main questions it aims to answer are: * What are the comp…

    Stage

    Phase 2

    Ages

    18 to 89

    Site

    Teachers College, Columbia University, New York, New York

    Run by

    Teachers College, Columbia University

    See if you can join NCT07036406 on ClinicalTrials.gov

15. Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia

    The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1.…

    Stage

    Phase 2

    Ages

    18 to 85

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06968663 on ClinicalTrials.gov

16. Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

    Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA who only speak one language (monolinguals), there is a significant nee…

    Stage

    Not phased

    Ages

    40 and older

    Site

    University of Texas at Austin, Austin, Texas

    Locations

    3 in total

    Run by

    Stephanie Grasso

    See if you can join NCT05741853 on ClinicalTrials.gov

17. Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia

    The current study aims to examine the benefits of an education/support group program for individuals with progressive aphasia (caused by various etiologies, diagnoses) and their carepartners. The current study utilizes pre-, post-treatment, and follow-up assessments to measure effects of a psychoed…

    Stage

    EARLY_Phase 1

    Ages

    18 and older

    Site

    University of Texas at Austin, Austin, Texas

    Run by

    University of Texas at Austin

    See if you can join NCT06511752 on ClinicalTrials.gov

18. Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

    This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effec…

    Stage

    Not phased

    Ages

    18 and older

    Site

    McCausland Center, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT07608588 on ClinicalTrials.gov

19. Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.

    62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analys…

    Stage

    Not phased

    Ages

    25 to 85

    Site

    University of New Mexico Center for Brain Recovery and Repair, Albuquerque, New Mexico

    Run by

    University of New Mexico

    See if you can join NCT04432883 on ClinicalTrials.gov

20. Mirror Speech Entrainment: A Novel Technique for Voice Personalized Speech Entrainment for Nonfluent Aphasia

    The goal of this clinical trial is to test the use of voice personalization through artificial intelligence (AI) voice cloning on speech entrainment tasks to improve language production of persons with aphasia (PWA). The main question the study aims to answer is: - What is the impact of personalize…

    Stage

    Not phased

    Ages

    18 to 70

    Site

    University of South Florida, Tampa, Florida

    Locations

    2 in total

    Run by

    University of South Florida

    See if you can join NCT06829420 on ClinicalTrials.gov

21. Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

    Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Pic…

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Language Rehab and Cognition Lab, Department of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    University of Pittsburgh

    See if you can join NCT05653440 on ClinicalTrials.gov

22. Telerehabilitation for Aphasia (TERRA)

    Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) t…

    Stage

    Not phased

    Ages

    21 to 80

    Site

    University of South Carolina Aphasia Lab, Columbia, South Carolina

    Run by

    University of South Carolina

    See if you can join NCT04682223 on ClinicalTrials.gov

23. Aphasia Physical EXercise Study: Randomized Trial

    The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-bod…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    University of California, Berkeley, Berkeley, California

    Locations

    4 in total

    Run by

    University of California, Berkeley

    See if you can join NCT07281313 on ClinicalTrials.gov

24. Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

    The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve co…

    Stage

    Phase 2

    Ages

    40 to 85

    Site

    University of Pennsylvania, Philadelphia, Pennsylvania

    Run by

    University of Pennsylvania

    See if you can join NCT06842745 on ClinicalTrials.gov

25. Effect of Community Choir Singing in People With Chronic Post-stroke Aphasia

    The goal of this randomized controled trial is to test the effects of assigning people with chronic post-stroke aphasia to 12 weekly choir sessions, compared to usual care. The main question it aims to answer is: Does the assignment to a choir singing program causes a beneficial effect on functiona…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Toronto Metropolitan University, Toronto, Ontario

    Locations

    4 in total

    Run by

    University of Ottawa

    See if you can join NCT06368323 on ClinicalTrials.gov