Aortic Valve Stenosis Clinical Trials

15 studies are recruiting for aortic valve stenosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry (STS/ACC TVT Registry™): Registry Purpose and Research Objective

   The STS/ACC TVT Registry™ (TVT Registry), created by The Society of Thoracic Surgeons (STS) and the American College of Cardiology Foundation (ACCF), is a benchmarking tool designed to assess the prevalence, demographics, management, and outcomes of patients undergoing transcatheter aortic valve re…

   Stage

   Not phased

   Ages

   18 and older

   Site

   American College of Cardiology / National Cardiovascular Data Registry, Washington D.C., District of Columbia

   Run by

   American College of Cardiology

   See if you can join NCT07908355 on ClinicalTrials.gov

2. ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

   The objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4/X4S Transcatheter Heart Valve (THV) in subjects who are at high or greater risk with a failing aortic bioprosthetic valve.

   Stage

   Not phased

   Ages

   Any age

   Site

   Bay Area Structural Heart at Sutter Health, San Francisco, California

   Locations

   37 in total

   Run by

   Edwards Lifesciences

   See if you can join NCT05172973 on ClinicalTrials.gov

3. CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation

   This trial evaluates the effectiveness of CardioHeartConnect, an eight-week mobile cardiac rehabilitation intervention using Peloton fitness modules, compared to educational control among patients recovering from transcatheter aortic valve replacement (TAVR). The study aims to improve physical acti…

   Stage

   Not phased

   Ages

   18 and older

   Site

   UCHealth Structural Heart and Valve Clinic, Aurora, Colorado

   Run by

   University of Colorado, Denver

   See if you can join NCT07008911 on ClinicalTrials.gov

4. CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

   The objective of this study is to demonstrate safety and efficacy of the EmStop Embolic Protection System when used as indicated to capture and remove thrombus/debris during self-expanding transcatheter aortic valve replacement (TAVR) procedures.

   Stage

   Not phased

   Ages

   22 and older

   Site

   Los Robles Regional Medical Center, Thousand Oaks, California

   Locations

   7 in total

   Run by

   EmStop Inc

   See if you can join NCT07276711 on ClinicalTrials.gov

5. Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR

   To assess the efficacy and safety of Intravascular Lithotripsy (IVL) in subjects undergoing transfemoral TAVR in patients with severe iliac disease, prohibitive for transfemoral TAVR in patients with severe symptomatic aortic stenosis, otherwise considered for alternative access TAVR. (e.g. trans-c…

   Stage

   Not phased

   Ages

   18 to 90

   Site

   Baylor Scott and White Heart Hospital, Plano, Texas

   Run by

   Baylor Research Institute

   See if you can join NCT05862558 on ClinicalTrials.gov

6. Patient Quality of Recovery After TAVR With Different Sedation Regimens

   The goal of this clinical trial is to learn whether the type of sedation medication used during a transcatheter aortic valve replacement (TAVR) affects how people recover after the procedure. The main question this study aims to answer is whether different sedation regimens (propofol, dexmedetomidi…

   Stage

   Phase 4

   Ages

   18 to 90

   Site

   Endeavor Health, Glenview, Illinois

   Run by

   David Lyubashevsky

   See if you can join NCT07556523 on ClinicalTrials.gov

7. Detecting Changes in Arterial Blood Volume and Cardiac Efficiency

   The objective of this Pilot Study is to demonstrate the efficacy of the Hemocept device in detecting changes in arterial blood volume and cardiac efficiency.

   Stage

   Not phased

   Ages

   18 to 80

   Site

   Boulder Heart, Boulder, Colorado

   Run by

   HemoCept Inc.

   See if you can join NCT07205341 on ClinicalTrials.gov

8. Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR

   Data on valve performance following ViV-TAVR has usually been obtained with the use of Doppler-echocardiography. However, some reports have shown significant discordances in the evaluation of mean transvalvular gradient between echocardiography and catheterization, with an overestimation of the rea…

   Stage

   Not phased

   Ages

   18 and older

   Site

   South Broward Hospital Disctrict D/B/A Memorial Healthcare System, Hollywood, Florida

   Locations

   7 in total

   Run by

   Institut universitaire de cardiologie et de pneumologie de Québec, University Laval

   See if you can join NCT05459233 on ClinicalTrials.gov

9. Imaging Histone Deacetylase in the Heart

   The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.

   Stage

   Not phased

   Ages

   18 to 85

   Site

   Massachusetts General Hospital, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT03549559 on ClinicalTrials.gov

10. PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

    This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis. Following completion of enrollment, subjects will be eligible for enrollment in …

    Stage

    Not phased

    Ages

    65 and older

    Site

    Heart Center LLC, Huntsville, Huntsville, Alabama

    Locations

    80 in total

    Run by

    Edwards Lifesciences

    See if you can join NCT04889872 on ClinicalTrials.gov

11. MRI in Transcatheter Aortic Valve Replacement Patients

    The hypothesis is that SEV result in superior valvular hemodynamics (more pronounced during exercise) and exercise capacity relative to BEV. Furthermore, the hypothesis is that stress CMR will be able to demonstrate differences in these hemodynamic parameters. CMR will also provide refined assessme…

    Stage

    Not phased

    Ages

    18 to 105

    Site

    University Hospitals Cleveland Medical Center, Cleveland, Ohio

    Run by

    University Hospitals Cleveland Medical Center

    See if you can join NCT05603026 on ClinicalTrials.gov

12. Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure

    The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple …

    Stage

    Not phased

    Ages

    18 and older

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Locations

    7 in total

    Run by

    Semmelweis University

    See if you can join NCT07016477 on ClinicalTrials.gov

13. Effect of Fetal Aortic Valvuloplasty on Outcomes

    In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects. The underdevelopment can occur gradually during fetal growth caused by a narrowing of the aortic valve. At so…

    Stage

    Not phased

    Ages

    0 to 0

    Site

    Fetal Cardiovascular Program, University of California San Francisco, San Francisco, California

    Locations

    13 in total

    Run by

    Queen Silvia Children's Hospital, Gothenburg, Sweden

    See if you can join NCT05386173 on ClinicalTrials.gov

14. Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial

    The study protocol is a randomized trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV). Namely, the therapies to which patients will be randomized will be transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacemen…

    Stage

    Not phased

    Ages

    50 and older

    Site

    Cedars-Sinai Medical Center, Los Angeles, California

    Run by

    Cedars-Sinai Medical Center

    See if you can join NCT06817148 on ClinicalTrials.gov

15. STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)

    The TVT Registry™ is a benchmarking tool developed to track patient safety and real-world outcomes related to the transcatheter aortic valve replacement (TAVR) procedure. Created by The Society of Thoracic Surgeons (STS) and the American College of Cardiology (ACC), the TVT Registry is designed to …

    Stage

    Not phased

    Ages

    18 and older

    Site

    American College of Cardiology, Washington D.C., District of Columbia

    Run by

    The Society of Thoracic Surgeons

    See if you can join NCT01737528 on ClinicalTrials.gov