Anesthesia Clinical Trials

22 studies are recruiting for anesthesia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

   The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (…

   Stage

   Not phased

   Ages

   18 and older

   Site

   University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas

   Locations

   24 in total

   Run by

   Washington University School of Medicine

   See if you can join NCT05991453 on ClinicalTrials.gov

2. Oral Methadone in Cardiac Surgery

   The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

   Stage

   Phase 4

   Ages

   18 and older

   Site

   Mayo Clinic in Rochester, Rochester, Minnesota

   Run by

   Mayo Clinic

   See if you can join NCT07221617 on ClinicalTrials.gov

3. A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

   The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressu…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Memorial Sloan Kettering Cancer Center (All protocol activites), New York, New York

   Run by

   Memorial Sloan Kettering Cancer Center

   See if you can join NCT05954832 on ClinicalTrials.gov

4. Anesthetics and Analgesics in Children

   The purpose of this study is to characterize the pharmacokinetic (PK) and safety profile of anesthetics and analgesics in children and adolescents.

   Stage

   Not phased

   Ages

   0 to 17

   Site

   Lucile Packard Children's Hospital, Stanford, California

   Locations

   13 in total

   Run by

   Chi Dang Hornik

   See if you can join NCT03427736 on ClinicalTrials.gov

5. Upper vs Lower Extremity BP in Spinal Cesarean Using ClearSight

   This is a single-center, prospective observational study in patients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia. It compares whether continuous noninvasive hemodynamic measurements from the lower extremity (toe) better predict neonatal outcomes than upper extre…

   Stage

   Not phased

   Ages

   18 and older

   Site

   The Ohio State University, Columbus, Ohio

   Run by

   Ohio State University

   See if you can join NCT07685730 on ClinicalTrials.gov

6. The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

   Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopr…

   Stage

   Phase 4

   Ages

   18 and older

   Site

   University of California, San Francisco, San Francisco, California

   Locations

   10 in total

   Run by

   University of California, San Francisco

   See if you can join NCT06802224 on ClinicalTrials.gov

7. Ketamine and Propofol NeuroImaging

   This is a multi-visit which will collect MRI (pictures of the brain) and EEG (brain waves) data to determine changes in brain connectivity and brain activity for memory formation and pain perception while receiving the commonly-used anesthetic agents ketamine and propofol, both alone and in combina…

   Stage

   EARLY_Phase 1

   Ages

   18 to 59

   Site

   University of Pittsburgh, Pittsburgh, Pennsylvania

   Run by

   Keith M Vogt

   See if you can join NCT07294092 on ClinicalTrials.gov

8. Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

   A comparison of two anesthetic techniques for total knee replacements: (1) Peri-Articular Injection (PAI), local infiltration between the popliteal artery and capsule of the knee block (IPACK) and single-shot adductor canal block (ACB) vs. (2) PAI, IPACK and continuous adductor canal block catheter…

   Stage

   Not phased

   Ages

   18 to 65

   Site

   Hospital for Special Surgery, New York, New York

   Run by

   Hospital for Special Surgery, New York

   See if you can join NCT03747146 on ClinicalTrials.gov

9. The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes

   Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes th…

   Stage

   Not phased

   Ages

   Any age

   Site

   Mass General Brigham Hospital Network of secondary, tertiary, and quaternary care hospitals, Boston, Massachusetts

   Run by

   Massachusetts General Hospital

   See if you can join NCT07022951 on ClinicalTrials.gov

10. Remimazolam NeuroImaging

    This is a single-arm functional MRI study that will determine the effects of remimazolam on cognition and brain activity and connectivity at rest, during noxious stimulation, and during a memory encoding task

    Stage

    EARLY_Phase 1

    Ages

    18 to 59

    Site

    University of Pittsburgh, Pittsburgh, Pennsylvania

    Run by

    Keith M Vogt

    See if you can join NCT07290205 on ClinicalTrials.gov

11. Prospective IR-led Sedation Feasibility

    This study wants to see if some interventional radiology (IR) procedures can be done without using general anesthesia. General anesthesia needs a lot of staff and equipment. It can also cause side effects. There are not enough anesthesia providers, which makes it harder to use for every procedure. …

    Stage

    Phase 1

    Ages

    18 and older

    Site

    CAMC Memorial, Charleston, West Virginia

    Run by

    CAMC Health System

    See if you can join NCT07443254 on ClinicalTrials.gov

12. REcovery From DEXmedetomidine-induced Unconsciousness

    This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine s…

    Stage

    Not phased

    Ages

    18 to 65

    Site

    Massachusetts General Hospital, Boston, Massachusetts

    Run by

    Massachusetts General Hospital

    See if you can join NCT06003127 on ClinicalTrials.gov

13. Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)

    The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%/75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%/25%…

    Stage

    Phase 3

    Ages

    18 and older

    Site

    Clements University Hospital, Dallas, Texas

    Run by

    University of Texas Southwestern Medical Center

    See if you can join NCT05358535 on ClinicalTrials.gov

14. Poke and a Placebo

    To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Minnesota, Minneapolis, Minnesota

    Run by

    University of Minnesota

    See if you can join NCT04497220 on ClinicalTrials.gov

15. Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

    In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration. It is important for an anesthesiologist to know if a child would respond to fluid administration so that …

    Stage

    Not phased

    Ages

    Up to 17

    Site

    Boston Children's Hospital, Boston, Massachusetts

    Run by

    Boston Children's Hospital

    See if you can join NCT03431064 on ClinicalTrials.gov

16. Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

    Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter

    Stage

    Phase 4

    Ages

    18 to 90

    Site

    University of Iowa Hospital and Clinics, Iowa City, Iowa

    Run by

    Melinda Seering

    See if you can join NCT05868330 on ClinicalTrials.gov

17. The Pediatric Anesthesia Quality Improvement Project

    The Study is designed to collect information about adverse events that occur in children undergoing anesthesia in participating hospitals. Demographic information will be collected on all anesthetics. An analysis of each adverse event will be performed and entered into the database. From this infor…

    Stage

    Not phased

    Ages

    Up to 21

    Site

    Phoenix Children's Hospital, Phoenix, Arizona

    Locations

    37 in total

    Run by

    The Society for Pediatric Anesthesia

    See if you can join NCT00674388 on ClinicalTrials.gov

18. Characterization of the Pudendal Nerve with Transvaginal Ultrasonography

    This is a feasibility study characterizing the ability of transvaginal ultrasonography to identify the pudendal nerve. Today, the pudendal nerve block is typically accomplished through blind landmark techniques, thus limiting its success. To date, there has never been an attempt to determine if the…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Virginia, Charlottesville, Virginia

    Run by

    University of Virginia

    See if you can join NCT06021782 on ClinicalTrials.gov

19. Pilot Feasibility Trial of the SafeLM Supraglottic Airway (SGA)

    The purpose of this study is to assess the feasibility of SafeLM as a primary airway device and as a conduit for intubation with and without the use of a bougie

    Stage

    Not phased

    Ages

    18 and older

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT05989880 on ClinicalTrials.gov

20. Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine

    The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine. Specifically, the investigators will be evaluating ease of laryngoscopy, vocal cord view, vocal cord opening, …

    Stage

    Phase 4

    Ages

    18 and older

    Site

    The University of Texas Health Science Center at Houston, Houston, Texas

    Run by

    The University of Texas Health Science Center, Houston

    See if you can join NCT06029049 on ClinicalTrials.gov

21. Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study

    Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric surgical population. The goal of this clinical trial is to determine whet…

    Stage

    Phase 4

    Ages

    70 to 110

    Site

    Oregon Health & Science University, Portland, Oregon

    Run by

    Oregon Health and Science University

    See if you can join NCT06036095 on ClinicalTrials.gov

22. Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

    To determine whether the addition of erector spinae plane (ESP) catheters to existing multimodal analgesic regimen with intrathecal morphine provides superior postoperative analgesia in patients undergoing hepatic resection compared with patients not receiving ESP catheters.

    Stage

    Phase 4

    Ages

    18 and older

    Site

    University of California, San Diego, San Diego, California

    Run by

    University of California, San Diego

    See if you can join NCT04849455 on ClinicalTrials.gov