Amyotrophic Lateral Sclerosis Clinical Trials

45 studies are recruiting for amyotrophic lateral sclerosis in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Boston, Massachusetts 13 Baltimore, Maryland 9 Jacksonville, Florida 9 New York, New York 9 Phoenix, Arizona 8 San Francisco, California 7 Chicago, Illinois 6 Miami, Florida 6 Philadelphia, Pennsylvania 6 St Louis, Missouri 6 Ann Arbor, Michigan 5 Birmingham, Alabama 5 Minneapolis, Minnesota 5 Seattle, Washington 5 Atlanta, Georgia 4 Dallas, Texas 4 Houston, Texas 4 Aurora, Colorado 3 Bethesda, Maryland 3 Columbia, Missouri 3 Columbus, Ohio 3 Durham, North Carolina 3 Indianapolis, Indiana 3 Irvine, California 3 La Jolla, California 3 Lebanon, New Hampshire 3 Los Angeles, California 3 Portland, Oregon 3 Sacramento, California 3 San Diego, California 3

Studies now recruiting

  1. Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells. Researchers want to understand whether these diseases have related causes or risk factors. Objective: To test people with movement or thinking and memory …

    Stage
    Not phased
    Ages
    18 to 110
    Site
    National Institutes of Health Clinical Center, Bethesda, Maryland
    Run by
    National Institute of Neurological Disorders and Stroke (NINDS)

    See if you can join NCT03225144 on ClinicalTrials.gov

  2. Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

    The goal of this clinical trial is to learn if the drug pridopidine works to treat amyotrophic lateral sclerosis in adults. It will also help to learn about the safety of pridopidine. The main question it aims to answer is: Does pridopidine slow disease progression of ALS? Researchers will compare …

    Stage
    Phase 3
    Ages
    18 to 80
    Site
    Barrow Neurological Institute, Phoenix, Arizona
    Locations
    55 in total
    Run by
    Prilenia

    See if you can join NCT07322003 on ClinicalTrials.gov

  3. Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

    PIONEER-ALS is a Phase 1/2, multicenter, open-label, ascending dose, uncontrolled, first-in-human study that will evaluate the safety, tolerability and effects on clinical and biomarker endpoints of intracisternal administration of Vtx-002 in participants with Amyotrophic Lateral Sclerosis (ALS). T…

    Stage
    Phase 1
    Ages
    18 and older
    Site
    University of California San Diego Medical Center, San Diego, California
    Locations
    11 in total
    Run by
    Vector Y Therapeutics

    See if you can join NCT07287397 on ClinicalTrials.gov

  4. Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

    This will be a single center, randomized, double-blind, placebo-controlled pilot study to assess the safety and tolerability of terazosin (TZ) at a dose of 5 milligrams (mg) per os (PO) daily for patients with amyotrophic lateral sclerosis (ALS). The primary outcome of this study is to determine wh…

    Stage
    EARLY_Phase 1
    Ages
    18 to 80
    Site
    University of Iowa Health Care, Iowa City, Iowa
    Run by
    University of Iowa

    See if you can join NCT07224269 on ClinicalTrials.gov

  5. A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)

    The primary objective of this dose-finding study is to evaluate the safety, tolerability and pharmacodynamics of single dose of INS1202 via IT administration in participants ≥ 18 to <80 years of age with ALS who carry superoxide dismutase type 1 (SOD1) mutations or harbor no known ALS-related genet…

    Stage
    Phase 1
    Ages
    18 to 79
    Site
    USA004, La Jolla, California
    Locations
    7 in total
    Run by
    Insmed Gene Therapy LLC

    See if you can join NCT07290062 on ClinicalTrials.gov

  6. Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

    The purpose of this study is to collect, from patients with sporadic and familial ALS and their family members, clinical data and blood samples for extraction of DNA, RNA, preparation of lymphocytes, plasma and serum to establish a repository for future investigations of genetic contributions to AL…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Mayo Clinic Florida, Jacksonville, Florida
    Run by
    Mayo Clinic

    See if you can join NCT05474235 on ClinicalTrials.gov

  7. ASSESS ALL ALS Study

    The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis (ALS) symptomatic, ALS gene carriers and control cohorts. This consortium is being funded by the National Institutes of Heal…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama Birmingham, Birmingham, Alabama
    Locations
    37 in total
    Run by
    St. Joseph's Hospital and Medical Center, Phoenix

    See if you can join NCT06578195 on ClinicalTrials.gov

  8. PREVENT ALL ALS Study

    The ALL ALS Clinical Research Consortium is establishing research to collect a wide range of samples, clinical information and measurements from Amyotrophic Lateral Sclerosis (ALS) symptomatic, ALS gene carriers and control cohorts. This consortium is begin funded by the National Institutes of Heal…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama Birmingham, Birmingham, Alabama
    Locations
    32 in total
    Run by
    St. Joseph's Hospital and Medical Center, Phoenix

    See if you can join NCT06581861 on ClinicalTrials.gov

  9. Investigation on the Cortical Communication (CortiCom) System

    The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor. Up to two grids will be implanted in the brain, for a total channel count of up to 128 channels, f…

    Stage
    Not phased
    Ages
    22 to 70
    Site
    Johns Hopkins Medicine, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT03567213 on ClinicalTrials.gov

  10. Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

    This study aims to study the feasibility of psilocybin therapy for patients with Amyotropic Lateral Sclerosis (ALS) with depressed mood. The secondary objective is to assess its impact on depression, quality of life, hopelessness, and functional status in this patient population.

    Stage
    EARLY_Phase 1
    Ages
    18 and older
    Site
    Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
    Run by
    Johns Hopkins University

    See if you can join NCT06656702 on ClinicalTrials.gov

  11. Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications

    The goal of this clinical trial is to learn about the effect of communicative interaction on verbal communication in people with amyotrophic lateral sclerosis (ALS) and age-matched speakers. The question is, What are the effects of communicative interaction on verbal communication in people with AL…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    Speech Core, Pennsylvania State University, University Park, Pennsylvania
    Run by
    Penn State University

    See if you can join NCT06266403 on ClinicalTrials.gov

  12. Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS

    The main objective of the proposed study is to evaluate if oral intake of EN formula preceding Gtube placement will impact tolerance upon placement and feeding via Gtube in pALS. This single arm intervention study all participants will receive the intervention and researchers will utilize validated…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Nova Southeastern University, Cathy J, Husman ALS Center, Fort Lauderdale, Florida
    Run by
    Andrea Charvet

    See if you can join NCT06609213 on ClinicalTrials.gov

  13. Multicenter ALS Imaging Study

    This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, line…

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Florida, Gainesville, Florida
    Locations
    3 in total
    Run by
    University of Minnesota

    See if you can join NCT06735014 on ClinicalTrials.gov

  14. ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) represents the formalized integration of ARTFL (U54 NS092089; funded through 2019) and LEFFTDS (U01 AG045390; funded through 2019) as a single North American research consortium to study FTLD for 2019 and beyond.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of Alabama Birmingham, Birmingham, Alabama
    Locations
    27 in total
    Run by
    Mayo Clinic

    See if you can join NCT04363684 on ClinicalTrials.gov

  15. Analysis of Human ALS Tissues and Registry of ALS Patients

    Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's Disease, is a progressive, terminal condition of muscle weakness that is associated with degeneration of neurons in the spinal cord and brain. This devastating disorder afflicts people in the prime of their lives. At the present…

    Stage
    Not phased
    Ages
    18 to 90
    Site
    University of Illinois at Chicago, Chicago, Illinois
    Run by
    University of Illinois at Chicago

    See if you can join NCT05067179 on ClinicalTrials.gov

  16. Neurologic Stem Cell Treatment Study

    This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will provide improvement in neurologic function for patients with certain n…

    Stage
    Not phased
    Ages
    18 and older
    Site
    MD Stem Cells, Westport, Connecticut
    Locations
    3 in total
    Run by
    MD Stem Cells

    See if you can join NCT02795052 on ClinicalTrials.gov

  17. Dazucorilant in Patients With Amyotrophic Lateral Sclerosis

    The purpose of this 2-part study is to assess the safety and efficacy of CORT113176 (dazucorilant) in patients with Amyotrophic Lateral Sclerosis (ALS).

    Stage
    Phase 2
    Ages
    18 and older
    Site
    062, Phoenix, Arizona
    Locations
    35 in total
    Run by
    Corcept Therapeutics

    See if you can join NCT05407324 on ClinicalTrials.gov

  18. Clinical Procedures to Support Research in ALS

    The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected in the medical record to learn more about a disease called amyotrophic lateral sclerosis (ALS) and related disorders.

    Stage
    Not phased
    Ages
    18 and older
    Site
    University of California, Irvine, Irvine, California
    Locations
    11 in total
    Run by
    University of Miami

    See if you can join NCT03489278 on ClinicalTrials.gov

  19. A Study of Ranolazine in ALS

    The purpose of this study is to evaluate safety, effect on cramps, function and quality of life of ranolazine versus placebo for the treatment of ALS.

    Stage
    Phase 2
    Ages
    18 and older
    Site
    University of California, San Francisco, San Francisco, California
    Locations
    6 in total
    Run by
    Swathy Chandrashekhar, MBBS

    See if you can join NCT06527222 on ClinicalTrials.gov

  20. Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone

    This study is being conducted to help the investigators better understand how the new FDA approved medication Edaravone (also known as Radicava) works in subsets of patients with ALS. The investigators are also trying to understand if there are specific ALS patients, with different presentations of…

    Stage
    Not phased
    Ages
    18 to 85
    Site
    Loma Linda University, Loma Linda, California
    Run by
    Loma Linda University

    See if you can join NCT04097158 on ClinicalTrials.gov

  21. Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

    The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

    Stage
    Not phased
    Ages
    18 to 80
    Site
    Stanford University School of Medicine, Stanford, California
    Locations
    2 in total
    Run by
    Leigh R. Hochberg, MD, PhD.

    See if you can join NCT05724173 on ClinicalTrials.gov

  22. BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

    The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

    Stage
    Not phased
    Ages
    18 to 80
    Site
    University of California, Davis, Sacramento, California
    Locations
    6 in total
    Run by
    Leigh R. Hochberg, MD, PhD.

    See if you can join NCT00912041 on ClinicalTrials.gov

  23. The National Amyotrophic Lateral Sclerosis Registry

    The purpose of this registry is to (A) better describe the incidence and prevalence of Amyotrophic Lateral Sclerosis (ALS) in the United States;(B) examine appropriate factors, such as environmental and occupational, that may be associated with the disease; (C) better outline key demographic factor…

    Stage
    Not phased
    Ages
    18 and older
    Site
    CDC, Atlanta, Georgia
    Run by
    Centers for Disease Control and Prevention

    See if you can join NCT01772602 on ClinicalTrials.gov

  24. EIM Via the Myolex mScan as an ALS Biomarker

    Amyotrophic lateral sclerosis (ALS) has been traditionally considered incurable and untreatable. But starting in the 1990s with the introduction of Riluzole, therapies are being discovered and ultimately approved for slowing disease progression. Many pharmaceutical companies continue to seek new th…

    Stage
    Not phased
    Ages
    18 and older
    Site
    Barrow Neurological Institute, Phoenix, Arizona
    Locations
    6 in total
    Run by
    Beth Israel Deaconess Medical Center

    See if you can join NCT06491732 on ClinicalTrials.gov

  25. Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

    The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an assistive communication device to decode imagined language correlates and speech for patients with …

    Stage
    Not phased
    Ages
    22 to 75
    Site
    University of California, Davis, Sacramento, California
    Locations
    3 in total
    Run by
    Paradromics

    See if you can join NCT07357428 on ClinicalTrials.gov

How to read this page. Every study here comes from ClinicalTrials.gov, the public registry that research teams are required to file with. We have summarised each one in plain language and shown where it is running. We have not changed what any study says it is doing.

What TrialBoost is. We help people find research that might suit them, and, if they ask us to, we pass their details to the research team running it. We are not a doctor, a research site, or a study sponsor, and we do not decide who takes part in anything. Joining costs nothing and you can change your mind at any point.

Paid placement. Some studies pay us when someone asks to be connected to them. Those are labelled Sponsored wherever they appear, and they only appear when they match what you were actually looking for.