Amblyopia Clinical Trials

15 studies are recruiting for amblyopia in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Psilocybin for Amblyopia - Targeting Critical Periods in Humans

   The purpose of this study is to evaluate whether ingestion of a drug called psilocybin can increase the effectiveness of amblyopia therapy in adults with amblyopia. Psilocybin is a naturally-occurring psychoactive compound found in many species of mushrooms. It can be ingested orally and can result…

   Stage

   Phase 1

   Ages

   18 to 65

   Site

   Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland

   Run by

   Johns Hopkins University

   See if you can join NCT07920081 on ClinicalTrials.gov

2. Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

   In children 4 to 7 years of age, to determine if treatment with 1 hour per day 6 days per week of watching dichoptic movies/shows wearing the Luminopia headset is non-inferior to treatment with 2 hours of patching per day 7 days per week with respect to change in amblyopic eye distance VA from rand…

   Stage

   Phase 3

   Ages

   4 to 7

   Site

   UAB Pediatric Eye Care; Birmingham Health Care, Birmingham, Alabama

   Locations

   73 in total

   Run by

   Jaeb Center for Health Research

   See if you can join NCT06380517 on ClinicalTrials.gov

3. Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

   Participants eligible for the study will be randomly allocated (1:1:1) to receive either Luminopia dichoptic treatment while wearing optical correction if needed, Vivid Vision dichoptic treatment while wearing optical correction if needed, or continued optical correction alone if needed, with clini…

   Stage

   Phase 3

   Ages

   8 to 12

   Site

   UAB Pediatric Eye Care; Birmingham Health Care, Birmingham, Alabama

   Locations

   58 in total

   Run by

   Jaeb Center for Health Research

   See if you can join NCT06524882 on ClinicalTrials.gov

4. OCT Eccentric Fixation and Amblyopia in Children

   The objectives of this proposal are to characterize the relationship between OCT eccentric fixation (OCT-EF), fixation eye movement (FEM), macular sensitivity in children with amblyopia.

   Stage

   Not phased

   Ages

   4 to 16

   Site

   SUNY College of Optometry, New York, New York

   Run by

   State University of New York College of Optometry

   See if you can join NCT05714449 on ClinicalTrials.gov

5. Valproate for the Treatment of Residual Amblyopia

   The goal of this clinical trial is to determine the efficacy of valproate as an adjunct therapy to treat amblyopia beyond the critical period in children aged 8-17 years who have amblyopia of ≥3 lines of interocular best-corrected (with glasses) visual acuity difference. The main questions it aims …

   Stage

   Phase 1

   Ages

   8 to 17

   Site

   Boston Children's Hospital, Boston, Massachusetts

   Run by

   Boston Children's Hospital

   See if you can join NCT07226141 on ClinicalTrials.gov

6. Video Treatment for Amblyopia

   The purpose of this study is to determine whether viewing asynchronous movies leads to better visual outcomes in young children with amblyopia than standard-of-care occlusion therapy with an adhesive patch and whether this is associated with better adherence to treatment.

   Stage

   Not phased

   Ages

   3 to 7

   Site

   Retina Foundation, Dallas, Texas

   Run by

   Retina Foundation of the Southwest

   See if you can join NCT05439200 on ClinicalTrials.gov

7. Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

   Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify var…

   Stage

   Not phased

   Ages

   0 to 90

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT04310241 on ClinicalTrials.gov

8. Binocular Amblyopia Treatment

   To evaluate the effectiveness of enhanced binocular amblyopia treatments in achieving a more complete and stable recovery.

   Stage

   Not phased

   Ages

   4 to 10

   Site

   Retina Foundation of the Southwest, Dallas, Texas

   Run by

   Retina Foundation of the Southwest

   See if you can join NCT03288948 on ClinicalTrials.gov

9. A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

   A randomized trial to determine whether simultaneous treatment with spectacles and patching has an equivalent VA outcome compared with sequential treatment, first with spectacles alone followed by patching (if needed), for previously untreated amblyopia in children 3 to <13 years of age.

   Stage

   Phase 3

   Ages

   3 to 13

   Site

   UAB Pediatric Eye Care; Birmingham Health Care, Birmingham, Alabama

   Locations

   68 in total

   Run by

   Jaeb Center for Health Research

   See if you can join NCT04378790 on ClinicalTrials.gov

10. Patch-free Occlusion Therapy

    The purpose of the study is to determine whether a patch-free occlusion therapy leads to better visual outcomes in young children with amblyopia than standard-of-care occlusion therapy with an adhesive patch and whether this is associated with better adherence to the treatment.

    Stage

    Not phased

    Ages

    3 to 12

    Site

    Retina Foundation, Dallas, Texas

    Run by

    Retina Foundation of the Southwest

    See if you can join NCT05440448 on ClinicalTrials.gov

11. Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

    Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

    Stage

    Not phased

    Ages

    Any age

    Site

    Nova Southeastern University College of Optometry, Fort Lauderdale, Florida

    Run by

    Nova Southeastern University

    See if you can join NCT05522972 on ClinicalTrials.gov

12. Amblyopia Treatment for Children Aged 8 to 12 Years

    This study is being done to assess the effect of at-home amblyopia treatment with Curesight™ for children aged 8 to 12 years. Curesight™ allows you to stream any videos on a computer screen at home but the amblyopic eye will see the entire screen clearly while part of the image will be blurred for …

    Stage

    Not phased

    Ages

    8 to 12

    Site

    Retina Foundation of the Southwest, Dallas, Texas

    Run by

    Retina Foundation of the Southwest

    See if you can join NCT07281742 on ClinicalTrials.gov

13. Clinical Data Registry of Amblyopia Patients on Luminopia Treatment

    Amblyopia is the most prevalent cause of reduced monocular visual acuity in children and young adults, with estimates of prevalence ranging from 1% to 5%. The most common associated amblyogenic risk factors are uncorrected anisometropia, strabismus, or a combination of these. In addition to reduced…

    Stage

    Not phased

    Ages

    Any age

    Site

    UCSF Benioff Children's Physicians, San Ramon, California

    Locations

    13 in total

    Run by

    Luminopia

    See if you can join NCT06429280 on ClinicalTrials.gov

14. Novel Amblyopia Treatment With Virtual Reality Games

    The goal of this study is to compare the change in amblyopic eye acuity between treatment periods in children with amblyopia, aged 5-17 years. The main question it aims to answer is: Is a 16-week course of amblyopia treatment using Vivid Vision Therapeutic (Dichoptic) Virtual Reality Games for appr…

    Stage

    Not phased

    Ages

    5 to 17

    Site

    The Ohio State University College of Optometry, Columbus, Ohio

    Run by

    Marjean Kulp

    See if you can join NCT06049459 on ClinicalTrials.gov

15. Noninvasive Brain Stimulation in Adult Amblyopia

    The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are: 1. What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of ad…

    Stage

    Not phased

    Ages

    18 to 55

    Site

    Midwestern University Eye Institute, Downers Grove, Illinois

    Run by

    Midwestern University

    See if you can join NCT06712849 on ClinicalTrials.gov