Alcohol Use Disorder (AUD) Clinical Trials

23 studies are recruiting for alcohol use disorder (aud) in the United States right now. Each one is listed on ClinicalTrials.gov, the public registry the research teams themselves file with. TrialBoost is not a doctor, a research site, or a study sponsor: the research team decides who takes part.

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Studies now recruiting

1. Exercise Training Decreases Alcohol Consumption and Tissue Injury by an FGF21-dependent Mechanism

   This randomized study will examine whether a 12-week supervised home-based endurance exercise program can reduce alcohol use and alcohol craving in adults with alcohol use disorder (AUD) and alcohol-related liver disease (ALD). Thirty participants will be assigned in a 1:1 ratio to endurance exerci…

   Stage

   Not phased

   Ages

   18 and older

   Site

   Cleveland Clinic, Cleveland, Ohio

   Run by

   The Cleveland Clinic

   See if you can join NCT07824089 on ClinicalTrials.gov

2. Imaging Mitochondrial Complex-I in Alcohol Use Disorder

   Studies proposed in this application will image mitochondrial Complex-I (MCI-I) and cerebral glucose metabolism (CGM) in alcohol use disorder (AUD) and matched healthy controls

   Stage

   EARLY_Phase 1

   Ages

   18 to 55

   Site

   University of PIttsburgh, Pittsburgh, Pennsylvania

   Run by

   Rajesh Narendran

   See if you can join NCT07825818 on ClinicalTrials.gov

3. The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

   This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

   Stage

   Phase 1

   Ages

   21 to 65

   Site

   Connecticut Mental Health Center, New Haven, Connecticut

   Run by

   Yale University

   See if you can join NCT06070649 on ClinicalTrials.gov

4. Sensory and Physical Reactions to Beverage Cues

   The goal of this clinical trial is to evaluate changes in craving and sensory responses to different beverage cues in adults (aged 21-70) with current mild or greater alcohol use disorder (AUD). The main questions it aims to answer are: * Does exposure to different beverage cues elicit distinct cha…

   Stage

   Not phased

   Ages

   21 to 70

   Site

   Univeristy of Texas Southwestern Medical Center, Dallas, Texas

   Run by

   University of Texas Southwestern Medical Center

   See if you can join NCT07788716 on ClinicalTrials.gov

5. Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers

   The purpose of this research study is to find out about the effects of a drug called mavoglurant on alcohol consumption.

   Stage

   Phase 1

   Ages

   21 to 50

   Site

   Connecticut Mental Health Center (SAC and SATU), New Haven, Connecticut

   Locations

   2 in total

   Run by

   Yale University

   See if you can join NCT06136195 on ClinicalTrials.gov

6. Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms

   Background: Alcohol use disorder (AUD) is a leading cause of disease and death worldwide. New treatments for AUD are needed. Dopamine, a chemical that carries signals between brain cells, is thought to play a role in alcohol addiction. Researchers want to learn how Suvorexant, a drug used to treat …

   Stage

   Phase 1

   Ages

   18 to 75

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT06484075 on ClinicalTrials.gov

7. Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)

   Background: Glucagon-like peptide 1 (GLP-1) agonist drugs are used to treat diabetes and aid weight loss. They may also help reduce cravings for drugs and alcohol. Researchers want to know if a GLP-1 drug (tirzepatide) can lessen the urge to drink in people with alcohol use disorder (AUD). Objectiv…

   Stage

   Phase 1

   Ages

   21 to 65

   Site

   National Institutes of Health Clinical Center, Bethesda, Maryland

   Run by

   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

   See if you can join NCT07559500 on ClinicalTrials.gov

8. Study of Tirzepatide for Recovery and Alcohol Use Management

   This is a pilot, 4-week, double-blind, placebo-controlled, randomized trial of individuals with alcohol use disorder (AUD) to receive weekly injections of either tirzepatide (n=10) or matching placebo (n=10). The primary aim is to determine the effects of tirzepatide on cue-reactivity among individ…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Brigham and Women's Faulkner Hospital, Jamaica Plain, Massachusetts

   Locations

   2 in total

   Run by

   Brigham and Women's Hospital

   See if you can join NCT06727331 on ClinicalTrials.gov

9. Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

   Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among treatment-seeking smokers with an alcohol use disorder (AUD) who have in…

   Stage

   Phase 2

   Ages

   18 and older

   Site

   Washington State University, Spokane, Washington

   Run by

   Washington State University

   See if you can join NCT05181891 on ClinicalTrials.gov

10. Optimizing Smart Technology for Addiction Recovery

    The goal of this study is to develop a machine-learning guided recovery messaging system. The main question it aims to answer is can messages be used to: * help people to improve their health * make changes in people's lives to address alcohol and substance use Participants will: * complete surveys…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Wisconsin, Madison, Wisconsin

    Run by

    University of Wisconsin, Madison

    See if you can join NCT07573540 on ClinicalTrials.gov

11. Suvorexant for Treatment of AUD and PTSD

    This study is to determine if suvorexant (SUV) will reduce insomnia in 76 men and women veteran and non-veterans between the ages 21-65 with posttraumatic stress disorder (PTSD) symptoms and alcohol use disorder (AUD). All participants will have a 7-day placebo run-in period, followed by a random a…

    Stage

    Phase 2

    Ages

    21 to 65

    Site

    University of California - Los Angeles, Los Angeles, California

    Locations

    2 in total

    Run by

    Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

    See if you can join NCT06679062 on ClinicalTrials.gov

12. Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

    Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974

    Stage

    Not phased

    Ages

    18 to 70

    Site

    Yale University, New Haven, Connecticut

    Run by

    Yale University

    See if you can join NCT07488819 on ClinicalTrials.gov

13. Assessing the Impact of dTMS on Neural Targets Associated With Alcohol Use Disorder

    The purpose of this study is to evaluate the efficacy of deep transcranial magnetic stimulation as a treatment for Veterans with Alcohol Use Disorder (AUD) to decrease the exceedingly high rate of relapse associated with this condition.

    Stage

    Not phased

    Ages

    18 to 75

    Site

    VA Palo Alto Health Care System, Palo Alto, California

    Run by

    Stanford University

    See if you can join NCT06949423 on ClinicalTrials.gov

14. MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

    The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to alcohol-related pictures. TMS and TBS are stimulation techniques that use magn…

    Stage

    Not phased

    Ages

    21 to 65

    Site

    Medical University of South Carolina, Charleston, South Carolina

    Run by

    Medical University of South Carolina

    See if you can join NCT04998916 on ClinicalTrials.gov

15. Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

    This study seeks to determine the feasibility, acceptability, and preliminary efficacy of an intervention consisting of off-label use of a medication with strong efficacy data for alcohol use disorder (AUD) with medical management and a clinical pharmacist-delivered behavioral intervention in reduc…

    Stage

    Phase 2

    Ages

    18 to 99

    Site

    Atlanta VA Medical Center, Decatur, Georgia

    Run by

    Yale University

    See if you can join NCT07040592 on ClinicalTrials.gov

16. Probenecid Administration for Alcohol Craving and Consumption

    This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.

    Stage

    Phase 2

    Ages

    18 and older

    Site

    Brown University, Providence, Rhode Island

    Run by

    Brown University

    See if you can join NCT07118618 on ClinicalTrials.gov

17. Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

    This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol. Phase 1: You'll be invited to share your perspective to help make the program relevant, inclusive, and affirm…

    Stage

    Not phased

    Ages

    18 and older

    Site

    University of Rhode Island, Providence, Rhode Island

    Run by

    University of Rhode Island

    See if you can join NCT07217795 on ClinicalTrials.gov

18. Combining a Smartphone App With Medications to Manage Heavy Drinking

    One in 10 Veterans have an alcohol use disorder. However, few Veterans receive evidenced-based psychosocial interventions or medications to treat alcohol use disorder. Barriers to receiving these treatments include long wait times, stigma, and long distances from treatment facilities. Even fewer Ve…

    Stage

    Not phased

    Ages

    18 to 80

    Site

    Phoenix VA Health Care System, Phoenix, AZ, Phoenix, Arizona

    Locations

    15 in total

    Run by

    VA Office of Research and Development

    See if you can join NCT06303778 on ClinicalTrials.gov

19. Effect of Sublingual Formulation of Dexmedetomidine Hydrochloride (HCl) (BXCL501) - Outpatient Study

    The overall objective of the proposed study is to determine if Dexmedetomidine HCl (BXCL501) is safe for treatment of alcohol use disorder (AUD) with comorbid posttraumatic stress disorder (PTSD) in an outpatient setting and also shows potential signals of efficacy thereby supporting the conduct of…

    Stage

    Phase 1

    Ages

    21 to 65

    Site

    VA Connecticut Healthcare System, West Haven, Connecticut

    Run by

    Pharmacotherapies for Alcohol and Substance Use Disorders Alliance

    See if you can join NCT06335407 on ClinicalTrials.gov

20. Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

    The study investigates the effects of alcohol consumption on social and individual behaviors using a within-subject design. Participants, aged 21-30, will attend two laboratory sessions approximately one week apart, participating as part of a dyad (pair). During one session, they will consume an al…

    Stage

    Not phased

    Ages

    21 to 30

    Site

    University of Illinois Urbana-Champaign, Champaign, Illinois

    Locations

    2 in total

    Run by

    University of Illinois at Urbana-Champaign

    See if you can join NCT07125534 on ClinicalTrials.gov

21. Developing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery

    The overarching goal of this study is to develop and examine the feasibility of a music-listening intervention that can be deployed in "real time" to regulate emotions and reduce momentary stress among young adults within the first 12 months of recovery from alcohol use disorder. We design the stud…

    Stage

    Not phased

    Ages

    18 to 35

    Site

    Washington State University Research Clinic, Spokane, Washington

    Run by

    Washington State University

    See if you can join NCT07052318 on ClinicalTrials.gov

22. Renewed Recovery: a Pilot Test of a Web-Based Mindfulness-Based Relapse Prevention Continuing Care Intervention for Alcohol Use Disorder

    This study aims to design, implement, and evaluate a pilot test of a web-based Mindfulness-Based Relapse Prevention (MBRP) continuing care intervention to support individuals with alcohol use disorder (AUD) exiting standard outpatient treatment. Guided by the Centre for eHealth and Wellbeing Resear…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Rescue Mission of Middle Georgia, Macon, Georgia

    Locations

    2 in total

    Run by

    University of Georgia

    See if you can join NCT06987526 on ClinicalTrials.gov

23. The Oklahoma Parent-Child Assistance Program

    The Parent-Child Assistance Program (PCAP) helps mothers who have used alcohol, opioids, or other drugs during pregnancy and their children through the work of highly trained, closely supervised case managers. Case managers work closely with mothers over the course of three years, meeting the mothe…

    Stage

    Not phased

    Ages

    18 and older

    Site

    Oklahoma City, Oklahoma City, Oklahoma

    Locations

    2 in total

    Run by

    University of Oklahoma

    See if you can join NCT05534568 on ClinicalTrials.gov